Bioactive Compound Details
| Compound ID: | B001664 |
| Source ID: | CHEMBL1200633 |
| Source Type: | Unknown |
| Compound Name: | IVERMECTIN |
| Synonyms: | 22,23-DIHYDRO C-076B1|22,23-DIHYDROABAMECTIN|22,23-DIHYDROAVERMECTIN B1|22,23-DIHYDROAVERMECTIN B1A|ACAREXX|BIMECTIN|BOVINET|CARDOMEC|CARDOTEK 30|CD-5024|CD5024|CEVAMEC|Cardomec|DIHYDROAVERMECTIN B1A|EQUIMEC|EQVALAN|Eqvalan|HEARTGARD|HYVERMECTIN|Heartguard|IVECTIN|IVERMECTIN|IVERMECTIN B1A|IVERMECTIN COMPONENT B1A|IVERTIN|IVOMEC|IVOSINT|Ivomec|JETAMEC|L 640471|L-640471|MECTIZAN|MK 933|MK-933|Mectizan|NORAMECTIN|NOROMECTIN|NSC-755843|ORAMEC|PANDEX|PHOENECTIN|SKLICE|SOOLANTRA|Stromectol|UVEMEC|VERMIC|VETMEC|ZIMECTERIN |
| Molecular Formula: | C95H146O28 |
| SMILES: | CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O |
| Molecular Species: | None |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T07 | Bile acid receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |
| T17 | Farnesoid X-activated receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |