Bioactive Compound Details
| Compound ID: | B067378 |
| Source ID: | CHEMBL1544 |
| Source Type: | Small molecule |
| Compound Name: | LIOTHYRONINE |
| Synonyms: | 3,5,3'-TRIIODOTHYRONINE, L-|CYRONINE|Cytomel|Euthroid-0.5|Euthroid-1|Euthroid-2|Euthroid-3|LEVOTHYROXINE SODIUM RELATED COMPOUND LIOTHYRONINE|LIOTHYRONINE|Liothyronine|NSC-80203|RATHYRONINE, (S)-|Rathyronine|Tertroxin|Thyrolar-0.25|Thyrolar-0.5|Thyrolar-1|Thyrolar-2|Thyrolar-3|Thyrolar-5|Triiodothyronine (T3 Or Liothyronine, Active) (6-11%)|Triostat |
| Molecular Formula: | C15H12I3NO4 |
| SMILES: | N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O |
| Molecular Species: | ZWITTERION |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T07 | Bile acid receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |
| T17 | Farnesoid X-activated receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |
| T06 | Glucagon-like peptide 1 receptor | GLP1R | agonist | GPCR | P43220 | GLP1R_HUMAN | Details |
| T05 | Peroxisome proliferator-activated receptor gamma | PPARG | agonist | Nuclear hormone receptor | P37231 | PPARG_HUMAN | Details |
| T26 | Thyroid hormone receptor beta | THRB | agonist | Nuclear hormone receptor | P10828 | THB_HUMAN | Details |