Investigational Drug Details
| Drug ID: | D196 |
| Drug Name: | Lactobacillus acidophilus |
| Synonyms: | Acidophilus; Bacillus acidophilus whole; Bacterium acidophilum whole; Lacteol; Lactobacillus acidophilus; Lactobacillus acidophilus whole; Lactobacterium acidophilum whole; Thermobacterium intestinale whole |
| Type: | Biological drug |
| DrugBank ID: | DB15823 |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | 68333-16-4 |
| Repositioning for NAFLD: | Yes |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Phase 2 on-going (IRCT201301223140N6) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0635 | IRCT201301223140N6 | Phase 2 | Not Recruiting | No Results Available | 16/01/2014 | 22 February 2018 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00010 | 35255811 | BMC Gastroenterol | The effect of daily consumption of probiotic yogurt on liver enzymes, steatosis and fibrosis in patients with nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized clinical trial. | Details |
| A00706 | 34994824 | Naunyn Schmiedebergs Arch Pharmacol | The crucial role of oxidative stress in non-alcoholic fatty liver disease-induced male reproductive toxicity: the ameliorative effects of Iranian indigenous probiotics. | Details |
| A02148 | 34486133 | J Food Biochem | Regulatory mechanisms of energy metabolism and inflammation in oleic acid-treated HepG2 cells from Lactobacillus acidophilus NX2-6 extract. | Details |
| A05053 | 33392241 | Front Nutr | The Effects of Foods on Blood Lipids in Non-alcoholic Fatty Liver Disease (NAFLD)-A Systematic Review and Meta-Analysis. | Details |
| A05331 | 33299871 | Biomed Res Int | Protective Role of Probiotic Supplements in Hepatic Steatosis: A Rat Model Study. | Details |
| A11346 | 30928918 | BMJ Open | Impact of bacterial probiotics on obesity, diabetes and non-alcoholic fatty liver disease related variables: a systematic review and meta-analysis of randomised controlled trials. | Details |
| A12812 | 30272851 | Asia Pac J Clin Nutr | Pro- and prebiotic effects on oxidative stress and inflammatory markers in non-alcoholic fatty liver disease. | Details |
| A14248 | 29507043 | J Endocrinol | Lactobacillus acidophilus NS1 attenuates diet-induced obesity and fatty liver. | Details |
| A16710 | 28230607 | J Pediatr Gastroenterol Nutr | Effects of Probiotics on Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents. | Details |
| A18939 | 26858714 | Front Microbiol | Ethanol Production by Selected Intestinal Microorganisms and Lactic Acid Bacteria Growing under Different Nutritional Conditions. | Details |
| A21459 | 25306266 | J Dairy Sci | Effects of probiotic yogurt consumption on metabolic factors in individuals with nonalcoholic fatty liver disease. | Details |
| A23899 | 23396737 | Ann Hepatol | Treatment of nonalcoholic steatohepatitis with probiotics. A proof-of-concept study. | Details |
| A25013 | 22247604 | J Clin Biochem Nutr | Supplementation with probiotics modifies gut flora and attenuates liver fat accumulation in rat nonalcoholic fatty liver disease model. | Details |
| A49413 | 35758473 | J Pediatr Gastroenterol Nutr | The benefit of probiotics in pediatric non-alcoholic fatty liver disease: a meta-analysis of randomized control trials. | Details |