Investigational Drug Details
| Drug ID: | D335 |
| Drug Name: | Silybum marianum |
| Synonyms: | -- |
| Type: | Herbal medicine |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | 1548994 |
| CasNo: | -- |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Phase 3 on-going (IRCT2017042824198N2) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0792 | IRCT20170430033730N2 | Not applicable | Not Recruiting | No Results Available | 02/07/2018 | 11 September 2018 | Details |
| L0807 | IRCT2017042824198N2 | Phase 3 | Recruiting | No Results Available | 19/11/2017 | 22 February 2018 | Details |
| L0813 | RBR-8dp876 | Not applicable | Not Recruiting | No Results Available | 19/09/2017 | 7 February 2022 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00207 | 35186807 | Can J Gastroenterol Hepatol | Therapeutic Effects of Milk Thistle (Silybum marianum L.) and Artichoke (Cynara scolymus L.) on Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Rats. | Details |
| A00243 | 35170400 | Bioengineered | Hepatoprotective mechanism of Silybum marianum on nonalcoholic fatty liver disease based on network pharmacology and experimental verification. | Details |
| A01214 | 34827721 | Biomolecules | The Effect of Mycotoxins and Silymarin on Liver Lipidome of Mice with Non-Alcoholic Fatty Liver Disease. | Details |
| A03200 | 34092291 | Chin J Nat Med | Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor α. | Details |
| A04524 | 33587330 | Phytother Res | Hepatic organic anion transporting polypeptides mediate disposition of milk thistle flavonolignans and pharmacokinetic silymarin-drug interactions. | Details |
| A04735 | 33520810 | J Diabetes Metab Disord | Lifestyle and silymarin: a fight against liver damage in NAFLD associated - prediabetic disease. | Details |
| A05577 | 33202166 | J Med Food | Water Extract of Artemisia annua L. Exhibits Hepatoprotective Effects Through Improvement of Lipid Accumulation and Oxidative Stress-Induced Cytotoxicity. | Details |
| A07242 | 32570937 | Nutrients | Treatment of Non-Alcoholic Steatosis: Preclinical Study of a New Nutraceutical Multitarget Formulation. | Details |
| A08380 | 32134732 | J Basic Clin Physiol Pharmacol | Silymarin: not just another antioxidant. | Details |
| A12993 | 30191499 | Dig Dis Sci | Silybin Alleviates Hepatic Steatosis and Fibrosis in NASH Mice by Inhibiting Oxidative Stress and Involvement with the Nf-κB Pathway. | Details |
| A13989 | 29655677 | Phytomedicine | An in vitro and in vivo study of a 4-herb formula on the management of diet-induced metabolic syndrome. | Details |
| A14395 | 29428667 | Biomed Pharmacother | Silybum marianum oil attenuates hepatic steatosis and oxidative stress in high fat diet-fed mice. | Details |
| A14773 | 29245314 | Medicine (Baltimore) | The therapeutic effect of silymarin in the treatment of nonalcoholic fatty disease: A meta-analysis (PRISMA) of randomized control trials. | Details |
| A15925 | 28648927 | J Ethnopharmacol | Silibinin Capsules improves high fat diet-induced nonalcoholic fatty liver disease in hamsters through modifying hepatic de novo lipogenesis and fatty acid oxidation. | Details |
| A16395 | 28419855 | Clin Gastroenterol Hepatol | A Randomized Trial of Silymarin for the Treatment of Nonalcoholic Steatohepatitis. | Details |
| A16856 | 28125040 | Molecules | Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years. | Details |
| A18141 | 27323620 | Zhongguo Zhong Xi Yi Jie He Za Zhi | [Effect of Compound Zhajin Granule on Toll-like Receptor 4 Signaling Pathway in Nonalcoholic Steatohepatitis Mice]. | Details |
| A18399 | 27158393 | Am J Transl Res | Silymarin attenuated hepatic steatosis through regulation of lipid metabolism and oxidative stress in a mouse model of nonalcoholic fatty liver disease (NAFLD). | Details |
| A19172 | 29953177 | Indian J Physiol Pharmacol | Herbal Induced Hepatoprotection and Hepatotoxicity: A Critical Review. | Details |
| A21148 | 25514914 | Rev Recent Clin Trials | Phytotherapy and NAFLD--from goals and challenges to clinical practice. | Details |