Investigational Drugs

Investigational drugs for NAFLD are derived from global clinical trials with the latest progress, and detailed drug properties are extracted from DrugBank and PubChem. For each drug, related therapeutic strategies, targets, and clinical trials in NAFLDkb are presented with knowledge graphs.

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     insulin resistance
42 records.
Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
D001 Acarbose Chemical drug DB00284 MGAM inhibitor;AMY2A inhibitor; AMY2B inhibitor; GAA inhibitor Improve insulin resistance Under clinical trials Details
D011 Anthocyanin Chemical drug -- -- Anti-inflammatory Failed in clinical trials Details
D012 Apararenone Chemical drug DB15024 Aldosterone receptor Improve insulin resistance Under clinical trials Details
D029 Berberine Chemical drug DB04115 AMPK activator Improve insulin resistance Under clinical trials Details
D032 Betaine Chemical drug DB06756 DNMTs stimulant Improve insulin resistance Under clinical trials Details
D033 Bezafibrate Chemical drug DB01393 PPARA agonist; PPARD agonist; PPARG agonist; NR1I2 partial agonist Improve insulin resistance; Anti-inflammatory Under clinical trials Details
D040 BIO89-100 Biological drug -- FGF21 analog Improve insulin resistance; Enhance lipid metabolism Under clinical trials Details
D046 Pegbelfermin Biological drug DB15365 FGF21 analog Improve insulin resistance; Enhance lipid metabolism; Anti-fibrosis Under clinical trials Details
D058 Canagliflozin Chemical drug DB08907 SGLT2 inhibitor Improve insulin resistance Under clinical trials Details
D107 Diacerein Chemical drug DB11994 ALOX5 inhibitor Antiarthritic drug; antiinflammatory agent Under clinical trials Details
D116 Dulaglutide Biological drug DB09045 GLP1R agonist Improve insulin resistance Under clinical trials Details
D122 Empagliflozin Chemical drug DB09038 SLC5A2 inhibitor; SGLT-2 inhibitor Improve insulin resistance Under clinical trials Details
D129 Exenatide Biological drug DB01276 GLP1R activator; GLP1R agonist Improve insulin resistance Under clinical trials Details
D154 Glimepiride Chemical drug DB00222 ABCC8 binder; KCNJ1 inhibitor; KCNJ11 inhibitor; KCNJ11 potassium channel inhibitor Antidiabetic drug Under clinical trials Details
D157 Glucophage Chemical drug DB00331 -- -- Under clinical trials Details
D160 Growth Hormone Biological drug DB00052 GHR ligand; PRLR ligand -- Under clinical trials Details
D171 HM15211 Biological drug -- GLP-1 agonist; GIP agonist; Glucagon triple agonist Improve insulin resistance Under clinical trials Details
D187 Ipragliflozin Chemical drug DB11698 SGLT2 inhibitor Improve insulin resistance Under clinical trials Details
D204 Licogliflozin Chemical drug DB15048 SGLT1 inhibitor; SGLT2 inhibitor Improve insulin resistance Under clinical trials Details
D207 Liraglutide Biological drug DB06655 GLP1R activator; GLP1R agonist; GCG receptor antagonist activity Improve insulin resistance Under clinical trials Details
D208 Lobeglitazone Chemical drug DB09198 PPARG activator Improve insulin resistance Under clinical trials Details
D221 MEDI0382 Chemical drug DB15194 GLP1R inhibitor; GCGR inhibitor Improve insulin resistance Under clinical trials Details
D225 Metformin Chemical drug DB00331 PRKAB1 inducer activator; ETEDH inhibitor; GPD1 inhibitor Improve insulin resistance Under clinical trials Details
D226 Metreleptin Biological drug DB09046 LEPR agonist CNS drug Under clinical trials Details
D232 Moxonidine Chemical drug DB09242 NISCH agonist -- Under clinical trials Details
D237 Nesinaact Chemical drug -- CD26 antigen inhibitor; PPARG agonist Improve insulin resistance Under clinical trials Details
D258 Omega 3 PUFA Chemical drug DB11133 PPARG ligand; PPARA activator Hypolipidemic drug Under clinical trials Details
D260 Orlistat Chemical drug DB01083 FASN inhibitor Enhance lipid metabolism Under clinical trials Details
D275 Pioglitazone Chemical drug DB01132 PPARG agonist Improve insulin resistance Advanced in clinical trials Details
D291 PXL065 Chemical drug -- AMPK activator Improve insulin resistance Under clinical trials Details
D292 PXL770 Chemical drug -- AMPK activator Improve insulin resistance Under clinical trials Details
D295 Qushi Huayu Decoction Traditional medicine -- AMPK activator Improve insulin resistance Under clinical trials Details
D311 Rosiglitazone Chemical drug DB00412 PPARG agonist; PPARA; PPARD Improve insulin resistance Failed in clinical trials Details
D321 Saroglitazar Chemical drug DB13115 PPARA agonist; PPARG agonist Antidiabetic drug Approved in India Details
D328 Serine Chemical drug DB00133 SRR Improve insulin resistance Under clinical trials Details
D343 Somatropin Biological drug DB00052 GHR ligand; PRLR ligand Hormone replacement drug Under clinical trials Details
D360 Telmisartan Chemical drug DB00966 PPARG partial agonist Improve insulin resistance Under clinical trials Details
D363 Tesamorelin Chemical drug DB08869 GHRHR agonist;GHRHR binder Growth stimulant Under clinical trials Details
D370 Tirzepatide Biological drug DB15171 GIP agonist; GLP-1 receptor agonist Improve insulin resistance Under clinical trials Details
D372 Tofogliflozin Chemical drug DB11824 SGLT2 inhibitor Improve insulin resistance Under clinical trials Details
D378 Troglitazone Chemical drug DB00197 PPARG agonist; PPARD; PPARA Improve insulin resistance Under investigation Details
D504 Polyunsaturated Fatty Acids Supplement -- -- -- Under clinical trials Details