| Trial ID: | L0899 |
| Source ID: | IRCT2014020516491N1
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| Associated Drug: |
CLA
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| Title: |
The effect of conjugated linoleic acid(CLA) on insulin resitsance, lipid profile, oxidative stress, inflammatory factors and resistin in obese patients with Non-alcoholic fatty liver disease (NAFLD) under weight loss diet :A randomized clinical control tr
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| Acronym: |
--
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| Status: |
Not Recruiting
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| Study Results: |
No Results Available
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| Results: |
--
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| Conditions: |
non- alcoholic fatty liver disease. <br>Fatty (change of) liver, not elsewhere classified;Fatty (change of) liver, not elsewhere classified
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| Interventions: |
Intervention 1: 3 caposouls of CLA(each containing 1000mg, daily 3000mg) with weight loss diet for eight weeks in intervention group. Intervention 2: weight loss diet for eight weks in control group.;Treatment - Drugs;Treatment - Other;3 caposouls of CLA(
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| Outcome Measures: |
Resistin. Timepoint: Beginning and end of the intervention. Method of measurement: Elisa.;Inflammatory factors(IL-6,Il-10,TNFa,hs-CRP). Timepoint: Begining and end of the study. Method of measurement: IL-6,Il-10,TNFa: Elisa and hs-CRP : immunoturbidimetry.;Insulin resistance and Insulin sensitivity. Timepoint: Beginning and end of the intervention. Method of measurement: Insulin resistance with HOMA-IR index and Insulin sensitivity with Quicki index.;Liver enzymes(AST-ALT-ALP). Timepoint: Beginning and end of the intervention. Method of measurement: IFCC.;Lipid profile. Timepoint: Beginning and end of the intervention. Method of measurement: Spectrophotometry and Friedewald Formula for LDL.;Oxidative Stress Indicies(TAC-ARE-MDA). Timepoint: Beginning and end of the intervention. Method of measurement: TAC and ARE : spectrophotometry and MDA : thiobarbituric acid.;?Sonography faindings. Timepoint: Beginning and end of the intervention. Method of measurement: Liver Sonography.Anthropometry(BMI-WC-WHR-WHtR). Timepoint: Beginning, second, fourth, sixth and end of the intervention. Method of measurement: metr, scale and stadiometr.;Body composition. Timepoint: Beginning and end of the intervention. Method of measurement: BIA.;Energy and nutrient intake. Timepoint: beginning, fourth week and end of the intervention. Method of measurement: 3 day food record.;Comparison of physical activity. Timepoint: beginning, fourth week and end of the intervention. Method of measurement: Physical Activity Questionnaire.
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| Sponsor/Collaborators: |
Deputy of research, Tabriz University of Medical Sciences
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| Gender: |
All
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| Age: |
20 years50 years
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| Phases: |
Not applicable
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| Enrollment: |
46
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| Study Type: |
interventional
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| Study Designs: |
Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment.
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| Start Date: |
09/06/2014
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| Completion Date: |
--
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| Results First Posted: |
--
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| Last Update Posted: |
22 February 2018
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| Locations: |
Iran (Islamic Republic of)
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| URL: |
http://en.irct.ir/trial/15422
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