| Abstract: | In phylogenesis, carnivorous animals initially and later herbivorous animals formed separate transfer of exogenous fatty acids in blood, predominantly palmitic acid and later - endogenous oleic acid pool, synthesized in hepatocytes from glucose. In vivo, exogenous fatty acids transfer α-lipoproteins to all cells and chylomicrons to hepatocytes. The endogenous oleic fatty acid, synthesized in hepatocytes is transferred to all cells by β-lipoproteins and to insulin-dependent lipoproteins of very low density. The limitation of cognitive biological function in herbivorous animals underlies the process of transferring of surplus amount of exogenous palmitic acid and alcohol cholesterol by β-lipoproteins becoming a non-physiological one. The bio-availability is affected concerning cells of exogenous polyene fatty acids that transfer in blood α-lipoproteins in carnivorous animals and at the first stage in herbivorous animals. The formation of palmitic non-ligand very low density lipoproteins-β-proteins is affected and their collection and partial utilization in intima generates lipoidosis. In summary, all this becomes a cause of formation of atherosclerosis and atheromatosis. The limitations in phylogenesis of cognitive biological function are considered as an etiological factor of metabolic pandemics. The etiological factors are specific for every one of metabolic pandemics and pathogenesis of all pandemics is developed following common algorithm. It is likely that metabolic pandemics (atherosclerosis and atheromatosis, metabolic essential arterial hypertension, metabolic syndrome, syndrome of insulin resistance, obesity and non-alcoholic fatty disease of liver)are quite not identical to nosologic forms of diseases if considered according etiological factors, pathogenesis and pathology rate in population. The exclusion of all inherent forms of disorder of metabolism of fatty acids and their transfer in β-lipoproteins demonstrates that problem of atherosclerosis, atheromatosis, coronarosclerosis and ischemic heart disease mainly turns out to be a case of eaten one's fill , a result of environment factors impact, disorder of biological function of trophology, biological reaction of exotrophy (external nutrition) and biological function of homeostasis. The prevention of atherosclerosis, atheromatosis and ischemic heart disease in population will be effective only under condition of obligatory individual support of actioning cognitive biological function by more complete biological function of intelligence. The active prevention of metabolic pandemics by force of personal development of cognitive biological function, intelligence function, provides no application of pharmaceuticals. The disorder of cognitive biological function is needed to be improved, incorrect positioning of Homo Sapiens species as omnivorous in animal world; Homo Sapiens is a herbivorous one. |
