Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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lipogenesis1889 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A45540 | 24030551 | Arterioscler Thromb Vasc Biol | Apolipoprotein A-IV expression in mouse liver enhances triglyceride secretion and reduces hepatic lipid content by promoting very low density lipoprotein particle expansion. | 2013 | Details |
| A45592 | 23731091 | J Agric Food Chem | Mulberry anthocyanins inhibit oleic acid induced lipid accumulation by reduction of lipogenesis and promotion of hepatic lipid clearance. | 2013 | Details |
| A45642 | 23493538 | Adv Nutr | Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people. | 2013 | Details |
| A45649 | 23467323 | Am J Physiol Regul Integr Comp Physiol | Hepatic steatosis development with four weeks of physical inactivity in previously active, hyperphagic OLETF rats. | 2013 | Details |
| A45662 | 23401290 | Hepatology | Liver fatty acid binding protein (L-Fabp) modulates murine stellate cell activation and diet-induced nonalcoholic fatty liver disease. | 2013 | Details |
| A45666 | 23374710 | Vitam Horm | Hormonal regulation of lipogenesis. | 2013 | Details |
| A45675 | 23322813 | Environ Health Perspect | Transgenerational inheritance of increased fat depot size, stem cell reprogramming, and hepatic steatosis elicited by prenatal exposure to the obesogen tributyltin in mice. | 2013 | Details |
| A45679 | 23304111 | PPAR Res | Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity. | 2012 | Details |
| A45709 | 23161873 | Endocrinology | The role of the carbohydrate response element-binding protein in male fructose-fed rats. | 2012 | Details |
| A45729 | 23035112 | J Biol Chem | Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver. | 2012 | Details |
| A45757 | 22921094 | Am J Obstet Gynecol | Nutrient sensor-mediated programmed nonalcoholic fatty liver disease in low birthweight offspring. | 2012 | Details |
| A45875 | 22243683 | Lipids Health Dis | Cyanidin-3-O-β-glucoside regulates fatty acid metabolism via an AMP-activated protein kinase-dependent signaling pathway in human HepG2 cells. | 2012 | Details |
| A45904 | 22152339 | Nutr Metab (Lond) | Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model. | 2011 | Details |
| A45916 | 22095841 | Hepatology | Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. | 2012 | Details |
| A46096 | 21123947 | J Clin Invest | Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. | 2010 | Details |
| A46141 | 20799351 | Hepatology | Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity. | 2010 | Details |
| A46174 | 20581678 | Curr Opin Lipidol | Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance. | 2010 | Details |
| A46222 | 20211032 | Lipids Health Dis | Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling. | 2010 | Details |
| A46223 | 20207831 | Endocrinology | A maternal "junk food" diet in pregnancy and lactation promotes nonalcoholic Fatty liver disease in rat offspring. | 2010 | Details |
| A46230 | 20159747 | Orv Hetil | [Patomechanisms of hepatic steatosis]. | 2010 | Details |
| A46244 | 20060143 | Metabolism | Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model. | 2010 | Details |
| A46246 | 20047129 | Swiss Med Wkly | Insulin resistance in chronic hepatitis C: mechanisms and clinical relevance. | 2009 | Details |
| A46283 | 19783528 | J Lipid Res | A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats. | 2009 | Details |
| A46294 | 19726979 | Curr Opin Clin Nutr Metab Care | Nutritional related liver disease: targeting the endoplasmic reticulum stress. | 2009 | Details |
| A46306 | 19616615 | Free Radic Biol Med | SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats. | 2009 | Details |
| A46321 | 19553925 | Obesity (Silver Spring) | Nonalcoholic hepatic steatosis in Zucker diabetic rats: spontaneous evolution and effects of metformin and fenofibrate. | 2009 | Details |
| A46342 | 19440711 | Semin Immunopathol | The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis: two triggers for one disease? | 2009 | Details |
| A46345 | 19403641 | Am J Clin Nutr | Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. | 2009 | Details |
| A46411 | 18972440 | Hepatology | Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. | 2008 | Details |
| A46416 | 18827582 | Curr Opin Clin Nutr Metab Care | Nonalcoholic fatty liver disease: the potential role of nutritional management. | 2008 | Details |
| A46420 | 18794597 | Eur J Gastroenterol Hepatol | Altered expression of transcription factors and genes regulating lipogenesis in liver and adipose tissue of mice with high fat diet-induced obesity and nonalcoholic fatty liver disease. | 2008 | Details |
| A46429 | 18719640 | Obesity (Silver Spring) | Efficiency of intermittent exercise on adiposity and fatty liver in rats fed with high-fat diet. | 2008 | Details |
| A46442 | 18627005 | Hepatology | Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice. | 2008 | Details |
| A46452 | 18542010 | Curr Opin Clin Nutr Metab Care | Role of dietary carbohydrates and macronutrients in the pathogenesis of nonalcoholic fatty liver disease. | 2008 | Details |
| A46470 | 18408460 | Curr Opin Gastroenterol | Recent advances in nonalcholic fatty liver disease. | 2008 | Details |
| A46517 | 18054848 | Dig Liver Dis | Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease. | 2007 | Details |
| A46653 | 16844679 | Am J Physiol Gastrointest Liver Physiol | Inhibition of matrix metalloproteinases increases PPAR-alpha and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model. | 2006 | Details |
| A46657 | 16825675 | Am J Clin Nutr | Nonalcoholic fatty liver, nonalcoholic steatohepatitis, ectopic fat, and the glycemic index. | 2006 | Details |
| A46682 | 16557554 | Hepatology | COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator. | 2006 | Details |
| A46755 | 15882516 | Med Clin (Barc) | [Pathogenesis of primary nonalcoholic fatty liver disease]. | 2005 | Details |
| A46777 | 15659701 | Pediatr Res | Omega-3 fatty acid supplementation prevents hepatic steatosis in a murine model of nonalcoholic fatty liver disease. | 2005 | Details |
| A46889 | 11296700 | Semin Liver Dis | Animal models of steatosis. | 2001 | Details |
| A46908 | 34817678 | Eur J Nutr | Betaine in ameliorating alcohol-induced hepatic steatosis. | 2021 | Details |
| A46912 | 34525389 | J Nutr Biochem | A mouse model of the regression of alcoholic hepatitis: Monitoring the regression of hepatic steatosis, inflammation, oxidative stress, and NAD+ metabolism upon alcohol withdrawal. | 2021 | Details |
| A46924 | 34116071 | Toxicol Appl Pharmacol | Liver-specific Nrf2 deficiency accelerates ethanol-induced lethality and hepatic injury in vivo. | 2021 | Details |
| A46943 | 33249138 | Free Radic Biol Med | The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver. | 2020 | Details |
| A46977 | 31493100 | Wien Klin Wochenschr | Patterns and prevalence of dyslipidemia in patients with different etiologies of chronic liver disease. | 2019 | Details |
| A46979 | 31479733 | Biochim Biophys Acta Mol Cell Biol Lipids | Estrogen-related receptor γ controls sterol regulatory element-binding protein-1c expression and alcoholic fatty liver. | 2019 | Details |
| A46991 | 31076642 | Cell Res | Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis. | 2019 | Details |
| A47019 | 29457836 | Hepatology | DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease. | 2018 | Details |
| A47030 | 28941686 | Food Res Int | Barley sprout extracts reduce hepatic lipid accumulation in ethanol-fed mice by activating hepatic AMP-activated protein kinase. | 2017 | Details |
| A47031 | 28882574 | Toxicology | Kupffer cells activation promoted binge drinking-induced fatty liver by activating lipolysis in white adipose tissues. | 2017 | Details |
| A47042 | 28424943 | Dig Dis Sci | Intestinal Alkaline Phosphatase Attenuates Alcohol-Induced Hepatosteatosis in Mice. | 2017 | Details |
| A47043 | 28274894 | J Ethnopharmacol | Effects of antrosterol from Antrodia camphorata submerged whole broth on lipid homeostasis, antioxidation, alcohol clearance, and anti-inflammation in livers of chronic-alcohol fed mice. | 2017 | Details |
| A47055 | 27746183 | Am J Pathol | Inhibition of Poly(ADP-Ribose) Polymerase-1 Protects Chronic Alcoholic Liver Injury. | 2016 | Details |
| A47077 | 26637972 | Biofactors | Endogenously elevated n-3 polyunsaturated fatty acids alleviate acute ethanol-induced liver steatosis. | 2015 | Details |
| A47085 | 26497211 | Oncotarget | Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro. | 2015 | Details |
| A47098 | 26022806 | J Lipid Res | Ethanol-induced hepatic steatosis is modulated by glycogen level in the liver. | 2015 | Details |
| A47100 | 25923904 | Zebrafish | Development of an Animal Model for Alcoholic Liver Disease in Zebrafish. | 2015 | Details |
| A47124 | 25557254 | J Pathol | 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. | 2015 | Details |
| A47147 | 24859453 | J Hepatol | Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury. | 2014 | Details |
| A47149 | 24833709 | Am J Physiol Gastrointest Liver Physiol | The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury. | 2014 | Details |
| A47150 | 24831094 | PLoS One | Absence of perilipin 2 prevents hepatic steatosis, glucose intolerance and ceramide accumulation in alcohol-fed mice. | 2014 | Details |
| A47151 | 24828027 | J Nutr | Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice. | 2014 | Details |
| A47189 | 23707365 | J Hepatol | ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. | 2013 | Details |
| A47222 | 22413959 | Alcohol Clin Exp Res | Carvedilol attenuates the progression of alcohol fatty liver disease in rats. | 2012 | Details |
| A47252 | 21386907 | PLoS One | Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury. | 2011 | Details |
| A47277 | 19588123 | Arch Toxicol | Ethanol and liver: recent advances in the mechanisms of ethanol-induced hepatosteatosis. | 2009 | Details |
| A47279 | 19371623 | Toxicol Appl Pharmacol | Honokiol reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes. | 2009 | Details |
| A47284 | 19170661 | Alcohol Clin Exp Res | Quantitative lipid metabolomic changes in alcoholic micropigs with fatty liver disease. | 2009 | Details |
| A47630 | 34732847 | Lab Invest | Hepatocyte-specific fibroblast growth factor 21 overexpression ameliorates high-fat diet-induced obesity and liver steatosis in mice. | 2021 | Details |
| A47656 | 34147666 | Prostaglandins Other Lipid Mediat | Loss of lysophosphatidic acid receptor 1 in hepatocytes reduces steatosis via down-regulation of CD36. | 2021 | Details |
| A47778 | 32065514 | Clin Pharmacol Drug Dev | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Liver-Targeting Acetyl-CoA Carboxylase Inhibitor (PF-05221304): A Three-Part Randomized Phase 1 Study. | 2020 | Details |
| A47914 | 29410095 | Biochem Biophys Res Commun | Loss of toll-like receptor 3 aggravates hepatic inflammation but ameliorates steatosis in mice. | 2018 | Details |
| A47950 | 28513320 | Cancer Biol Ther | CRISPR/Cas9-based Pten knock-out and Sleeping Beauty Transposon-mediated Nras knock-in induces hepatocellular carcinoma and hepatic lipid accumulation in mice. | 2017 | Details |
| A47974 | 27659424 | Am J Physiol Gastrointest Liver Physiol | Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity. | 2016 | Details |
| A47980 | 27443844 | Mol Cell Biochem | A20 reduces lipid storage and inflammation in hypertrophic adipocytes via p38 and Akt signaling. | 2016 | Details |
| A48067 | 25213859 | J Biol Chem | Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice. | 2014 | Details |
| A48257 | 18316359 | Diabetes | Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis. | 2008 | Details |
| A48363 | 15199412 | J Clin Invest | Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. | 2004 | Details |
| A48507 | 35123128 | Mol Metab | Crosstalk between TM4SF5 and GLUT8 regulates fructose metabolism in hepatic steatosis. | 2022 | Details |
| A48717 | 30817309 | Rev Neurosci | The effects of dietary methionine restriction on the function and metabolic reprogramming in the liver and brain - implications for longevity. | 2019 | Details |
| A48824 | 27498701 | Sci Rep | Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury. | 2016 | Details |
| A48851 | 26651978 | Curr Drug Metab | Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection. | 2016 | Details |
| A48891 | 25463480 | Biochim Biophys Acta | Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice. | 2014 | Details |
| A49006 | 21545524 | J Gastroenterol Hepatol | Pathogenesis of alcohol-induced liver disease: classical concepts and recent advances. | 2011 | Details |
| A49051 | 19957376 | Hepatology | Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse. | 2010 | Details |
| A49125 | 16622296 | Endocrine | Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome. | 2006 | Details |
| A49216 | 35820743 | BMJ Open | Efficacy and safety of guanabenz acetate treatment for non-alcoholic fatty liver disease: a study protocol for a randomised investigator-initiated phase IIa study. | 2022 | Details |
| A49292 | 35797133 | JCI Insight | Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity. | 2022 | Details |
| A49299 | 35795562 | Front Pharmacol | Multi-Omics Integration Analysis Identifies Lipid Disorder of a Non-Alcoholic Fatty Liver Disease (NAFLD) Mouse Model Improved by Zexie-Baizhu Decoction. | 2022 | Details |
| A49346 | 35782914 | Front Nutr | The Human Milk Oligosaccharide 2'-Fucosyllactose Alleviates Liver Steatosis, ER Stress and Insulin Resistance by Reducing Hepatic Diacylglycerols and Improved Gut Permeability in Obese Ldlr-/-.Leiden Mice. | 2022 | Details |
| A49378 | 35769097 | Front Bioeng Biotechnol | LncRNA MALAT1 Promotes PPARα/CD36-Mediated Hepatic Lipogenesis in Nonalcoholic Fatty Liver Disease by Modulating miR-206/ARNT Axis. | 2022 | Details |
| A49402 | 35762160 | Curr Opin Clin Nutr Metab Care | Omega-3 fatty acids and metabolic partitioning of fatty acids within the liver in the context of nonalcoholic fatty liver disease. | 2022 | Details |
| A49425 | 35754743 | PPAR Res | Liver Protective Effect of Fenofibrate in NASH/NAFLD Animal Models. | 2022 | Details |
| A49443 | 35748073 | Yonsei Med J | Canagliflozin Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism and Inhibiting Inflammation through Induction of Autophagy. | 2022 | Details |
| A49512 | 35730208 | Clin Mol Hepatol | Auranofin attenuates hepatic steatosis and fibrosis in non-alcoholic fatty liver disease via NRF2 and NF-κB signaling pathways. | 2022 | Details |
| A49531 | 35723408 | Curr Issues Mol Biol | Validation of a Quantification Method for Curcumin Derivatives and Their Hepatoprotective Effects on Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A49549 | 35718233 | Life Sci | Physical exercise and the functions of microRNAs. | 2022 | Details |
| A49562 | 35713152 | J Cell Mol Med | Celecoxib attenuates hepatosteatosis by impairing de novo lipogenesis via Akt-dependent lipogenic pathway. | 2022 | Details |