Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A01875 | 34576229 | Int J Mol Sci | Methyl Brevifolincarboxylate Attenuates Free Fatty Acid-Induced Lipid Metabolism and Inflammation in Hepatocytes through AMPK/NF-κB Signaling Pathway. | 2021 | Details |
| A01876 | 34576136 | Int J Mol Sci | Sex Dimorphism of Nonalcoholic Fatty Liver Disease (NAFLD) in Pparg-Null Mice. | 2021 | Details |
| A01877 | 34576091 | Int J Mol Sci | Establishment of an Adult Medaka Fatty Liver Model by Administration of a Gubra-Amylin-Nonalcoholic Steatohepatitis Diet Containing High Levels of Palmitic Acid and Fructose. | 2021 | Details |
| A01887 | 34572442 | Biomedicines | Dietary Patterns Influence Target Gene Expression through Emerging Epigenetic Mechanisms in Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01941 | 34558644 | Mol Med Rep | PPARγ attenuates hepatic inflammation and oxidative stress of non‑alcoholic steatohepatitis via modulating the miR‑21‑5p/SFRP5 pathway. | 2021 | Details |
| A01982 | 34543321 | PLoS One | Fatty liver index as a predictive marker for the development of diabetes: A retrospective cohort study using Japanese health check-up data. | 2021 | Details |
| A01990 | 34537182 | Anal Biochem | Cerebrovascular alterations in NAFLD: Is it increasing our risk of Alzheimer's disease? | 2021 | Details |
| A02012 | 34531129 | Dig Liver Dis | Troglitazone inhibits hepatic oval cell proliferation by inducing cell cycle arrest through Hippo/YAP pathway regulation. | 2021 | Details |
| A02022 | 34528723 | Aliment Pharmacol Ther | Randomised clinical trial: Pemafibrate, a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), versus placebo in patients with non-alcoholic fatty liver disease. | 2021 | Details |
| A02031 | 34525916 | Curr Med Chem | Beneficial Effects of Dietary Polyphenols in the Prevention and Treatment of NAFLD: Cell-Signaling Pathways Underlying Health Effects. | 2022 | Details |
| A02036 | 34524512 | Histochem Cell Biol | Fat causes necrosis and inflammation in parenchymal cells in human steatotic liver. | 2021 | Details |
| A02067 | 34512784 | Evid Based Complement Alternat Med | Cinnamic Acid Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Hepatic Lipogenesis and Promoting Fatty Acid Oxidation. | 2021 | Details |
| A02107 | 34505423 | Endocrinol Diabetes Metab | Oxy210, a novel inhibitor of hedgehog and TGF-β signalling, ameliorates hepatic fibrosis and hypercholesterolemia in mice. | 2021 | Details |
| A02129 | 34496264 | J Ethnopharmacol | Mechanism by which Eucommia ulmoides leaves Regulate Nonalcoholic fatty liver disease based on system pharmacology. | 2021 | Details |
| A02144 | 34488621 | Mol Med | MiR-100 overexpression attenuates high fat diet induced weight gain, liver steatosis, hypertriglyceridemia and development of metabolic syndrome in mice. | 2021 | Details |
| A02157 | 34482357 | Med Sci Monit | Live Combined B. subtilis and E. faecium Alleviate Liver Inflammation, Improve Intestinal Barrier Function, and Modulate Gut Microbiota in Mice with Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A02161 | 34479550 | BMC Complement Med Ther | Administration of hydro-alcoholic extract of spinach improves oxidative stress and inflammation in high-fat diet-induced NAFLD rats. | 2021 | Details |
| A02181 | 34471049 | Biol Pharm Bull | Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR α/γ Dual Agonist. | 2021 | Details |
| A02194 | 34465857 | Int J Obes (Lond) | Obese mice weight loss role on nonalcoholic fatty liver disease and endoplasmic reticulum stress treated by a GLP-1 receptor agonist. | 2021 | Details |
| A02204 | 34461220 | Pharmacol Res | Identification of the anti-fungal drug fenticonazole nitrate as a novel PPARγ-modulating ligand with good therapeutic index: Structure-based screening and biological validation. | 2021 | Details |
| A02209 | 34459761 | Wiad Lek | ASSOCIATION ANALYSIS OF PIOGLITAZONE EFFECTIVENESS IN TREATMENT OF NAFLD PATIENTS WITH OBESITY AND PPARG RS1801282 (PRO12ALA) GENOTYPE. | 2021 | Details |
| A02234 | 34450194 | Prog Lipid Res | PARPs in lipid metabolism and related diseases. | 2021 | Details |
| A02244 | 34447968 | J Anim Sci Technol | Effect of ciglitazone on adipogenic transdifferentiation of bovine skeletal muscle satellite cells. | 2021 | Details |
| A02254 | 34445644 | Int J Mol Sci | Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome. | 2021 | Details |
| A02256 | 34445549 | Int J Mol Sci | Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells. | 2021 | Details |
| A02279 | 34439491 | Antioxidants (Basel) | TRPM2 Non-Selective Cation Channels in Liver Injury Mediated by Reactive Oxygen Species. | 2021 | Details |
| A02280 | 34439474 | Antioxidants (Basel) | Garcinia cambogia Ameliorates Non-Alcoholic Fatty Liver Disease by Inhibiting Oxidative Stress-Mediated Steatosis and Apoptosis through NRF2-ARE Activation. | 2021 | Details |
| A02310 | 34425199 | Int J Biochem Cell Biol | Sulfated glucuronomannan hexasaccharide G6S1 enhanced lipolysis and lipophagy via PPARα pathway. | 2021 | Details |
| A02326 | 34417811 | Endocrinology | Rosiglitazone Requires Hepatocyte PPARγ Expression to Promote Steatosis in Male Mice With Diet-Induced Obesity. | 2021 | Details |
| A02342 | 34410623 | Hum Cell | Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression. | 2021 | Details |
| A02385 | 34394332 | PPAR Res | Computational Analysis of Gly482Ser Single-Nucleotide Polymorphism in PPARGC1A Gene Associated with CAD, NAFLD, T2DM, Obesity, Hypertension, and Metabolic Diseases. | 2021 | Details |
| A02396 | 34389043 | Clin Epigenetics | A targeted multi-omics approach reveals paraoxonase-1 as a determinant of obesity-associated fatty liver disease. | 2021 | Details |
| A02397 | 34387896 | Hepatology | Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice. | 2021 | Details |
| A02426 | 34374658 | J Physiol Pharmacol | Hesperidin, a novel candidate for the successful treatment of high fat diet plus ethanol-induced fatty liver disease in mice. | 2021 | Details |
| A02437 | 34371946 | Nutrients | Expression of Jejunal Taste Receptors in Women with Morbid Obesity. | 2021 | Details |
| A02443 | 34370218 | Clin J Gastroenterol | Efficacy of elafibranor in patients with liver abnormalities especially non-alcoholic steatohepatitis: a systematic review and meta-analysis. | 2021 | Details |
| A02455 | 34365685 | FASEB J | Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease. | 2021 | Details |
| A02458 | 34364973 | Biochim Biophys Acta Gen Subj | Copper and lipid metabolism: A reciprocal relationship. | 2021 | Details |
| A02502 | 34349877 | Nutr Res Pract | Efficacy of nobiletin in improving hypercholesterolemia and nonalcoholic fatty liver disease in high-cholesterol diet-fed mice. | 2021 | Details |
| A02523 | 34341928 | Environ Sci Pollut Res Int | Metronidazole enhances steatosis-related early-stage hepatocarcinogenesis in high fat diet-fed rats through DNA double-strand breaks and modulation of autophagy. | 2021 | Details |
| A02528 | 34340181 | Environ Pollut | An adverse outcome pathway based in vitro characterization of novel flame retardants-induced hepatic steatosis. | 2021 | Details |
| A02529 | 34339945 | Phytomedicine | Investigating the medicinal potential, material basis and mechanism of Polygoni Orientalis Fructus based on multi-technology integrated network pharmacology. | 2021 | Details |
| A02561 | 34328120 | Biomed Pharmacother | Molecular mechanism of DLBS3733, a bioactive fraction of Lagerstroemia speciosa (L.) Pers., on ameliorating hepatic lipid accumulation in HepG2 cells. | 2021 | Details |
| A02587 | 34321850 | World J Gastroenterol | PPARGC1A rs8192678 G>A polymorphism affects the severity of hepatic histological features and nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease. | 2021 | Details |
| A02622 | 34306045 | PPAR Res | Activation of the Peroxisome Proliferator-Activated Receptors (PPAR-α/γ) and the Fatty Acid Metabolizing Enzyme Protein CPT1A by Camel Milk Treatment Counteracts the High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A02648 | 34298687 | Cancers (Basel) | Abnormal Metabolism in the Progression of Nonalcoholic Fatty Liver Disease to Hepatocellular Carcinoma: Mechanistic Insights to Chemoprevention. | 2021 | Details |
| A02682 | 34285335 | Exp Mol Med | Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue. | 2021 | Details |
| A02689 | 34281337 | J Agric Food Chem | γ-Linolenic Acid Prevents Lipid Metabolism Disorder in Palmitic Acid-Treated Alpha Mouse Liver-12 Cells by Balancing Autophagy and Apoptosis via the LKB1-AMPK-mTOR Pathway. | 2021 | Details |
| A02704 | 34277668 | Front Med (Lausanne) | Exposure to Plasma From Non-alcoholic Fatty Liver Disease Patients Affects Hepatocyte Viability, Generates Mitochondrial Dysfunction, and Modulates Pathways Involved in Fat Accumulation and Inflammation. | 2021 | Details |
| A02710 | 34276360 | Front Pharmacol | Network Pharmacological Analysis and Experimental Validation of the Mechanisms of Action of Si-Ni-San Against Liver Fibrosis. | 2021 | Details |
| A02711 | 34276221 | Diabetes Metab Syndr Obes | Biochanin A Regulates Cholesterol Metabolism Further Delays the Progression of Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A02751 | 34260003 | Neurochem Res | Resveratrol Protects SH-SY5Y Cells Against Oleic Acid-Induced Glucolipid Metabolic Dysfunction and Cell Injuries Via the Wnt/β-Catenin Signalling Pathway. | 2021 | Details |
| A02772 | 34249621 | Quant Imaging Med Surg | Gender-specific liver aging and magnetic resonance imaging. | 2021 | Details |
| A02826 | 34228977 | Biochimie | Citrin deficiency: Does the reactivation of liver aralar-1 come into play and promote HCC development? | 2021 | Details |
| A02850 | 34219361 | Liver Int | PPAR-γ-induced changes in visceral fat and adiponectin levels are associated with improvement of steatohepatitis in patients with NASH. | 2021 | Details |
| A02857 | 34214406 | Expert Opin Investig Drugs | Anti-diabetic drugs and NASH: from current options to promising perspectives. | 2021 | Details |
| A02917 | 34199258 | J Clin Med | The Association between Vitamin D and Nonalcoholic Fatty Liver Disease Assessed by Controlled Attenuation Parameter. | 2021 | Details |
| A02937 | 34191493 | Anal Chem | Exploring the Changes of Peroxisomal Polarity in the Liver of Mice with Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A02995 | 34171397 | J Ethnopharmacol | Emodin palliates high-fat diet-induced nonalcoholic fatty liver disease in mice via activating the farnesoid X receptor pathway. | 2021 | Details |
| A03002 | 34168429 | Drug Des Devel Ther | Metformin in Combination with Malvidin Prevents Progression of Non-Alcoholic Fatty Liver Disease via Improving Lipid and Glucose Metabolisms, and Inhibiting Inflammation in Type 2 Diabetes Rats. | 2021 | Details |
| A03020 | 34161164 | J Med Food | Protective Role of Dietary Capsanthin in a Mouse Model of Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03022 | 34160360 | Turk J Gastroenterol | The Changing Prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) in Turkey in the Last Decade. | 2021 | Details |
| A03058 | 34151243 | JHEP Rep | Aramchol downregulates stearoyl CoA-desaturase 1 in hepatic stellate cells to attenuate cellular fibrogenesis. | 2021 | Details |
| A03067 | 34144391 | Redox Biol | Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARγ binodal complementary modules. | 2021 | Details |
| A03071 | 34142329 | Fish Physiol Biochem | Metabolism and antioxidation regulation of total flavanones from Sedum sarmentosum Bunge against high-fat diet-induced fatty liver disease in Nile tilapia (Oreochromis niloticus). | 2021 | Details |
| A03103 | 34130208 | Nutr Res | A rise in Proteobacteria is an indicator of gut-liver axis-mediated nonalcoholic fatty liver disease in high-fructose-fed adult mice. | 2021 | Details |
| A03107 | 34128328 | Chem Biodivers | Effect of Compounds from Moringa oleifera Lam. on in Vitro Non-Alcoholic Fatty Liver Disease (NAFLD) Model System. | 2021 | Details |
| A03129 | 34119399 | Acad Radiol | Comparison of the Effects of Hepatic Steatosis on Monoexponential DWI, Intravoxel Incoherent Motion Diffusion-weighted Imaging and Diffusion Kurtosis Imaging. | 2021 | Details |
| A03199 | 34092976 | World J Gastroenterol | COVID-19 in normal, diseased and transplanted liver. | 2021 | Details |
| A03200 | 34092291 | Chin J Nat Med | Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor α. | 2021 | Details |
| A03204 | 34091047 | Clin Gastroenterol Hepatol | The Placebo Response in Randomized Trials in Nonalcoholic Steatohepatitis Simply Explained. | 2021 | Details |
| A03212 | 34088068 | Sci Total Environ | Cadmium chloride induces non-alcoholic fatty liver disease in rats by stimulating miR-34a/SIRT1/FXR/p53 axis. | 2021 | Details |
| A03231 | 34078528 | BMB Rep | Porphyromonas gingivalis exacerbates the progression of fatty liver disease via CD36-PPARγ pathway. | 2021 | Details |
| A03232 | 34078383 | J Transl Med | Comprehensive analysis of LncRNAs expression profiles in an in vitro model of steatosis treated with Exendin-4. | 2021 | Details |
| A03247 | 34072832 | Cells | Epigenetic Regulation of Peroxisome Proliferator-Activated Receptor Gamma Mediates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A03252 | 34070893 | Mar Drugs | Attenuating Effects of Dieckol on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Decreasing the NLRP3 Inflammasome and Pyroptosis. | 2021 | Details |
| A03267 | 34065270 | Nutrients | Comparison of the Improvement Effect of Deep Ocean Water with Different Mineral Composition on the High Fat Diet-Induced Blood Lipid and Nonalcoholic Fatty Liver Disease in a Mouse Model. | 2021 | Details |
| A03279 | 34063472 | Int J Mol Sci | The Potential Protective Role of RUNX1 in Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03282 | 34062416 | Biomed Pharmacother | The HIF-2α/PPARα pathway is essential for liraglutide-alleviated, lipid-induced hepatic steatosis. | 2021 | Details |
| A03293 | 34058074 | FEBS J | Role of Mcpip1 in obesity-induced hepatic steatosis as determined by myeloid and liver-specific conditional knockouts. | 2021 | Details |
| A03296 | 34056769 | Phytother Res | Molecular updates on berberine in liver diseases: Bench to bedside. | 2021 | Details |
| A03302 | 34052187 | Biochem Pharmacol | Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and their exosomes alleviate non-alcoholic steatohepatitis: Emphasis on caspase-2 signaling inhibition. | 2021 | Details |
| A03322 | 34046014 | Front Endocrinol (Lausanne) | Spinal Cord Injury Reduces Serum Levels of Fibroblast Growth Factor-21 and Impairs Its Signaling Pathways in Liver and Adipose Tissue in Mice. | 2021 | Details |
| A03359 | 34028830 | Med J Aust | Prevalence of non-alcoholic fatty liver disease in regional Victoria: a prospective population-based study. | 2021 | Details |
| A03364 | 34027340 | JHEP Rep | Genetic predisposition similarities between NASH and ASH: Identification of new therapeutic targets. | 2021 | Details |
| A03365 | 34027337 | JHEP Rep | Defatting strategies in the current era of liver steatosis. | 2021 | Details |
| A03377 | 34025131 | J Ginseng Res | Effect of Korean Red Ginseng on metabolic syndrome. | 2020 | Details |
| A03384 | 34022528 | Bioorg Med Chem | Discovery of novel modulators for the PPARα (peroxisome proliferator activated receptor α): Potential therapies for nonalcoholic fatty liver disease. | 2021 | Details |
| A03413 | 34010603 | Exp Eye Res | The role of peroxisome proliferator-activated receptors in healthy and diseased eyes. | 2021 | Details |
| A03418 | 34007294 | Evid Based Complement Alternat Med | Mechanism of Huo-Xue-Qu-Yu Formula in Treating Nonalcoholic Hepatic Steatosis by Regulating Lipid Metabolism and Oxidative Stress in Rats. | 2021 | Details |
| A03447 | 33995543 | Evid Based Complement Alternat Med | Network Pharmacology-Based Investigation of the Therapeutic Mechanisms of Action of Danning Tablets in Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03460 | 33992930 | Eur J Med Chem | Natural products and analogs as preventive agents for metabolic syndrome via peroxisome proliferator-activated receptors: An overview. | 2021 | Details |
| A03468 | 33991615 | Cell Signal | Secretory Galectin-3 promotes hepatic steatosis via regulation of the PPARγ/CD36 signaling pathway. | 2021 | Details |
| A03482 | 33987427 | Ann Transl Med | Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention. | 2021 | Details |
| A03492 | 33984335 | Metabolism | Fenofibrate, a PPARα agonist, reduces hepatic fat accumulation through the upregulation of TFEB-mediated lipophagy. | 2021 | Details |
| A03526 | 33969054 | World J Clin Cases | Polycystic ovary syndrome: Pathways and mechanisms for possible increased susceptibility to COVID-19. | 2021 | Details |
| A03531 | 33966916 | Arch Med Res | Hepatic Accumulation of Hypoxanthine: A Link Between Hyperuricemia and Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03572 | 33948987 | FASEB J | Porphyran-derived oligosaccharides alleviate NAFLD and related cecal microbiota dysbiosis in mice. | 2021 | Details |
| A03605 | 33934381 | Hepatology | Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk. | 2021 | Details |
| A03623 | 33926085 | Genes (Basel) | The Role of Lipid Sensing Nuclear Receptors (PPARs and LXR) and Metabolic Lipases in Obesity, Diabetes and NAFLD. | 2021 | Details |