Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A16318 | 28462076 | Mol Metab | Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis. | 2017 | Details |
| A16326 | 28458161 | Biomed Pharmacother | Total sesquiterpene glycosides from Loquat (Eriobotrya japonica) leaf alleviate high-fat diet induced non-alcoholic fatty liver disease through cytochrome P450 2E1 inhibition. | 2017 | Details |
| A16332 | 28454924 | Toxicol Appl Pharmacol | Dual effect of silymarin on experimental non-alcoholic steatohepatitis induced by irinotecan. | 2017 | Details |
| A16339 | 28448552 | PLoS One | Transcriptomic analysis of the hepatic response to stress in the red cusk-eel (Genypterus chilensis): Insights into lipid metabolism, oxidative stress and liver steatosis. | 2017 | Details |
| A16352 | 28442507 | J Endocrinol | Protein kinase STK25 aggravates the severity of non-alcoholic fatty pancreas disease in mice. | 2017 | Details |
| A16365 | 28436449 | Sci Rep | Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients. | 2017 | Details |
| A16376 | 28428634 | Nat Rev Gastroenterol Hepatol | Lipid droplets and liver disease: from basic biology to clinical implications. | 2017 | Details |
| A16377 | 28428362 | J Endocrinol | Hepatic lipid accumulation: cause and consequence of dysregulated glucoregulatory hormones. | 2017 | Details |
| A16384 | 28425467 | Sci Rep | Hyperpolarized 13C Spectroscopic Evaluation of Oxidative Stress in a Rodent Model of Steatohepatitis. | 2017 | Details |
| A16393 | 28420164 | Int J Mol Sci | The Angiogenesis Inhibitor ALS-L1023 from Lemon-Balm Leaves Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease through Regulating the Visceral Adipose-Tissue Function. | 2017 | Details |
| A16399 | 28419000 | Exerc Sport Sci Rev | Exercise-Induced Autophagy in Fatty Liver Disease. | 2017 | Details |
| A16401 | 28417532 | Diabetes Obes Metab | Non-alcoholic fatty liver disease (NAFLD) prevalence and its metabolic associations in patients with type 1 diabetes and type 2 diabetes. | 2017 | Details |
| A16402 | 28416740 | Oncotarget | Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease. | 2017 | Details |
| A16406 | 28414138 | Biochem Pharmacol | Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. | 2017 | Details |
| A16411 | 28411267 | Diabetes | NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway. | 2017 | Details |
| A16412 | 28411170 | Biochim Biophys Acta Biomembr | The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease. | 2017 | Details |
| A16432 | 28393690 | Curr Med Chem | Hepatic AMP Kinase as a Potential Target for Treating Nonalcoholic Fatty Liver Disease: Evidence from Studies of Natural Products. | 2018 | Details |
| A16433 | 28392404 | Prog Lipid Res | A global perspective on FOXO1 in lipid metabolism and lipid-related diseases. | 2017 | Details |
| A16444 | 28383715 | Nutr Rev | Dietary sphingolipids: potential for management of dyslipidemia and nonalcoholic fatty liver disease. | 2017 | Details |
| A16449 | 28381740 | Intern Med | The Associations between Circulating Bile Acids and the Muscle Volume in Patients with Non-alcoholic Fatty Liver Disease (NAFLD). | 2017 | Details |
| A16452 | 28378853 | Eur J Clin Nutr | Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample. | 2017 | Details |
| A16457 | 28376109 | PLoS One | Association of leukocyte cell-derived chemotaxin 2 (LECT2) with NAFLD, metabolic syndrome, and atherosclerosis. | 2017 | Details |
| A16463 | 28373762 | World J Gastroenterol | Traditional Chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease. | 2017 | Details |
| A16495 | 28356106 | Lipids Health Dis | Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice. | 2017 | Details |
| A16496 | 28355557 | Cell Rep | Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet. | 2017 | Details |
| A16519 | 28344322 | Acta Pharmacol Sin | Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation. | 2017 | Details |
| A16520 | 28341541 | Mol Aspects Med | Pro-resolving actions of SPM in adipose tissue biology. | 2017 | Details |
| A16524 | 28337300 | Am J Transl Res | Mutation of miR-21 targets endogenous lipoprotein receptor-related protein 6 and nonalcoholic fatty liver disease. | 2017 | Details |
| A16528 | 28335383 | Int J Mol Sci | A Biomedical Investigation of the Hepatoprotective Effect of Radix salviae miltiorrhizae and Network Pharmacology-Based Prediction of the Active Compounds and Molecular Targets. | 2017 | Details |
| A16529 | 28334911 | Hum Mol Genet | MERTK rs4374383 variant predicts incident nonalcoholic fatty liver disease and diabetes: role of mononuclear cell activation and adipokine response to dietary fat. | 2017 | Details |
| A16562 | 28315901 | Med Sci Monit | The Effect of Sitagliptin on Lipid Metabolism of Fatty Liver Mice and Related Mechanisms. | 2017 | Details |
| A16563 | 28314735 | Gut | Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases. | 2017 | Details |
| A16568 | 28300221 | Sci Rep | Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats. | 2017 | Details |
| A16570 | 28300161 | Sci Rep | FOXO transcription factors protect against the diet-induced fatty liver disease. | 2017 | Details |
| A16582 | 28297799 | Zhonghua Gan Zang Bing Za Zhi | [A serum lipidomic study of patients with non-alcoholic fatty liver disease]. | 2017 | Details |
| A16593 | 28294174 | Eur J Clin Nutr | Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study. | 2017 | Details |
| A16599 | 28290069 | Clin J Gastroenterol | Significance of genetic polymorphisms in patients with nonalcoholic fatty liver disease. | 2017 | Details |
| A16604 | 28287811 | Arch Iran Med | Two Triacylglycerol Pathway Genes, CTDNEP1 and LPIN1, are Down-Regulated by hsa-miR-122-5p in Hepatocytes. | 2017 | Details |
| A16608 | 28285648 | Metabolism | Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice. | 2017 | Details |
| A16629 | 28275212 | Int J Mol Sci | Long Non-Coding RNA Profiling in a Non-Alcoholic Fatty Liver Disease Rodent Model: New Insight into Pathogenesis. | 2017 | Details |
| A16636 | 28271632 | IUBMB Life | The role of insufficient copper in lipid synthesis and fatty-liver disease. | 2017 | Details |
| A16637 | 28271033 | Mol Metab | Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis. | 2017 | Details |
| A16638 | 28271032 | Mol Metab | Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice. | 2017 | Details |
| A16641 | 28270609 | Proc Natl Acad Sci U S A | Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis. | 2017 | Details |
| A16642 | 28270444 | Am J Physiol Endocrinol Metab | α-Linolenic acid supplementation and exercise training reveal independent and additive responses on hepatic lipid accumulation in obese rats. | 2017 | Details |
| A16652 | 28264426 | Nutrients | The Combination of Blueberry Juice and Probiotics Ameliorate Non-Alcoholic Steatohepatitis (NASH) by Affecting SREBP-1c/PNPLA-3 Pathway via PPAR-α. | 2017 | Details |
| A16660 | 28258704 | Hepatol Res | Non-alcoholic fatty liver disease phosphoproteomics: A functional piece of the precision puzzle. | 2017 | Details |
| A16661 | 28257781 | Food Chem Toxicol | Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: Role of disturbed lipid homeostasis and increased oxidative stress. | 2017 | Details |
| A16681 | 28249273 | Dig Dis | Intestinal Farnesoid X Receptor and Takeda G Protein Couple Receptor 5 Signaling in Metabolic Regulation. | 2017 | Details |
| A16686 | 28244519 | Food Funct | A diet containing a high- versus low-daidzein level does not protect against liver steatosis in the obese Zucker rat model. | 2017 | Details |
| A16691 | 28241817 | BMC Endocr Disord | Berberine improves glucogenesis and lipid metabolism in nonalcoholic fatty liver disease. | 2017 | Details |
| A16707 | 28231800 | Lipids Health Dis | Dietary intervention, but not losartan, completely reverses non-alcoholic steatohepatitis in obese and insulin resistant mice. | 2017 | Details |
| A16711 | 28230324 | Diabetes Obes Metab | Effects of short-term energy restriction on liver lipid content and inflammatory status in severely obese adults: Results of a randomized controlled trial using 2 dietary approaches. | 2017 | Details |
| A16720 | 28223710 | Sci Rep | High-Intensity Aerobic Exercise Improves Both Hepatic Fat Content and Stiffness in Sedentary Obese Men with Nonalcoholic Fatty Liver Disease. | 2017 | Details |
| A16729 | 28219837 | J Nutr Biochem | Chronic maternal calcium and 25-hydroxyvitamin D deficiency in Wistar rats programs abnormal hepatic gene expression leading to hepatic steatosis in female offspring. | 2017 | Details |
| A16732 | 28218651 | Int J Mol Sci | Proteome Characteristics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas. | 2017 | Details |
| A16740 | 28214524 | Gastroenterology | Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease. | 2017 | Details |
| A16750 | 28211103 | J Neuroendocrinol | Impaired learning and memory in rats induced by a high-fat diet: Involvement with the imbalance of nesfatin-1 abundance and copine 6 expression. | 2017 | Details |
| A16754 | 28207798 | PLoS One | Altered hepatic lipid metabolism in mice lacking both the melanocortin type 4 receptor and low density lipoprotein receptor. | 2017 | Details |
| A16756 | 28205519 | Nat Commun | Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance. | 2017 | Details |
| A16762 | 28195199 | Sci Rep | Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis. | 2017 | Details |
| A16766 | 28194019 | Cell Mol Immunol | IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity. | 2017 | Details |
| A16772 | 28189916 | J Nutr Biochem | Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver. | 2017 | Details |
| A16773 | 28187366 | J Nutr Biochem | A combination of dietary N-3 fatty acids and a cyclooxygenase-1 inhibitor attenuates nonalcoholic fatty liver disease in mice. | 2017 | Details |
| A16775 | 28185191 | Methods Mol Biol | A Coupled Approach Utilizing Immunohistochemistry and Immunocytochemistry to Visualize Cellular Lipophagy. | 2017 | Details |
| A16776 | 28184213 | Front Endocrinol (Lausanne) | Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease. | 2017 | Details |
| A16803 | 28164196 | Food Funct | Preventive effect of Silibinin in combination with Pu-erh tea extract on non-alcoholic fatty liver disease in ob/ob mice. | 2017 | Details |
| A16807 | 28161992 | Am J Chin Med | Antrodia cinnamomea Prevents Obesity, Dyslipidemia, and the Derived Fatty Liver via Regulating AMPK and SREBP Signaling. | 2017 | Details |
| A16811 | 28159867 | J Lipid Res | Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase. | 2017 | Details |
| A16813 | 28158893 | Drug Res (Stuttg) | Efficacy and Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial. | 2017 | Details |
| A16819 | 28153708 | Biochim Biophys Acta Mol Basis Dis | Steroidogenic acute regulatory protein (StAR) overexpression attenuates HFD-induced hepatic steatosis and insulin resistance. | 2017 | Details |
| A16833 | 28139281 | Clin Nutr | Non-alcoholic fatty liver disease and its treatment with n-3 polyunsaturated fatty acids. | 2017 | Details |
| A16837 | 28134852 | Int J Mol Sci | Metabolomic Fingerprinting in the Comprehensive Study of Liver Changes Associated with Onion Supplementation in Hypercholesterolemic Wistar Rats. | 2017 | Details |
| A16842 | 28132890 | Gastroenterology | Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis. | 2017 | Details |
| A16843 | 28132721 | Immunobiology | Hepatic interleukin-6 production is maintained during endotoxin tolerance and facilitates lipid accumulation. | 2017 | Details |
| A16844 | 28131861 | Toxicology | Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis. | 2017 | Details |
| A16850 | 28127199 | World J Gastroenterol | Mitochondrial carnitine palmitoyl transferase-II inactivity aggravates lipid accumulation in rat hepatocarcinogenesis. | 2017 | Details |
| A16861 | 28123944 | Mol Metab | Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1. | 2016 | Details |
| A16867 | 28120165 | J Inherit Metab Dis | Investigating the link of ACAD10 deficiency to type 2 diabetes mellitus. | 2017 | Details |
| A16868 | 28119530 | Int J Obes (Lond) | Decreased lipid metabolism but increased FA biosynthesis are coupled with changes in liver microRNAs in obese subjects with NAFLD. | 2017 | Details |
| A16876 | 28115523 | J Biol Chem | APOC3 Protein Is Not a Predisposing Factor for Fat-induced Nonalcoholic Fatty Liver Disease in Mice. | 2017 | Details |
| A16879 | 28112684 | J Clin Invest | Out of the frying pan: dietary saturated fat influences nonalcoholic fatty liver disease. | 2017 | Details |
| A16880 | 28112681 | J Clin Invest | Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance. | 2017 | Details |
| A16888 | 28109892 | Free Radic Biol Med | Lipid oxidation products in the pathogenesis of non-alcoholic steatohepatitis. | 2017 | Details |
| A16890 | 28109099 | Nan Fang Yi Ke Da Xue Xue Bao | [Effect of Hugan Qingzhi tablets on AMPK pathway activation and NF-κB-p65 protein expression in the liver of rats with nonalcoholic fatty liver disease]. | 2017 | Details |
| A16892 | 28108233 | J Hepatol | Murine CD103+ dendritic cells protect against steatosis progression towards steatohepatitis. | 2017 | Details |
| A16936 | 28084058 | J Diabetes Investig | Selective peroxisome proliferator-activated receptor-α modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-α pathway and improves lipid metabolism in mice. | 2017 | Details |
| A16944 | 28081181 | PLoS One | Aronia melanocarpa Extract Ameliorates Hepatic Lipid Metabolism through PPARγ2 Downregulation. | 2017 | Details |
| A16951 | 28077274 | Biochimie | The role and regulation of the peroxisome proliferator activated receptor alpha in human liver. | 2017 | Details |
| A16984 | 28063505 | Nutrition | Alternative treatment methods attenuate the development of NAFLD: A review of resveratrol molecular mechanisms and clinical trials. | 2016 | Details |
| A17015 | 28044208 | J Gastroenterol | Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis. | 2017 | Details |
| A17032 | 29911800 | Yao Xue Xue Bao | [Protective effect and underlying mechanism of cordycepin on non-alcoholic fatty liver in ob/ob mice]. | 2017 | Details |
| A17038 | 28036028 | Nutrients | Application of an In Vivo Hepatic Triacylglycerol Production Method in the Setting of a High-Fat Diet in Mice. | 2016 | Details |
| A17051 | 28027934 | Biochem Biophys Res Commun | Histone modifications in FASN modulated by sterol regulatory element-binding protein 1c and carbohydrate responsive-element binding protein under insulin stimulation are related to NAFLD. | 2016 | Details |
| A17052 | 28027788 | Atherosclerosis | Non-alcoholic fatty liver disease and subclinical atherosclerosis: A comparison of metabolically- versus genetically-driven excess fat hepatic storage. | 2016 | Details |
| A17058 | 28017785 | Mol Cell Endocrinol | Hepatic lipid metabolism and non-alcoholic fatty liver disease in aging. | 2016 | Details |
| A17061 | 28013023 | Semin Cell Dev Biol | Metabolic roles of poly(ADP-ribose) polymerases. | 2016 | Details |
| A17075 | 28006772 | Cell Physiol Biochem | Involvement of Sphingosine 1-Phosphate in Palmitate-Induced Non-Alcoholic Fatty Liver Disease. | 2016 | Details |
| A17078 | 28003715 | J Clin Exp Hepatol | High-Fructose Intake Impairs the Hepatic Hypolipidemic Effects of a High-Fat Fish-Oil Diet in C57BL/6 Mice. | 2016 | Details |
| A17091 | 27996362 | Toxicol Mech Methods | The effects of di 2-ethyl hexyl phthalate (DEHP) on cellular lipid accumulation in HepG2 cells and its potential mechanisms in the molecular level. | 2017 | Details |