Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A03632 | 33924115 | Int J Mol Sci | Chronic High Fat Diet Intake Impairs Hepatic Metabolic Parameters in Ovariectomized Sirt3 KO Mice. | 2021 | Details |
| A03665 | 33915261 | J Nutr Biochem | Consumption of soybean or olive oil at recommended concentrations increased the intestinal microbiota diversity and insulin sensitivity and prevented fatty liver compared to the effects of coconut oil. | 2021 | Details |
| A03683 | 33903148 | Gut | Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target. | 2021 | Details |
| A03747 | 33879188 | Lipids Health Dis | TWIST2 and the PPAR signaling pathway are important in the progression of nonalcoholic steatohepatitis. | 2021 | Details |
| A03753 | 33877366 | Diabetologia | Liver-targeting drugs and their effect on blood glucose and hepatic lipids. | 2021 | Details |
| A03769 | 33869707 | Pract Lab Med | High-throughput nuclear magnetic resonance measurement of citrate in serum and plasma in the clinical laboratory. | 2021 | Details |
| A03778 | 33867326 | Pak J Pharm Sci | Effects of shikonin from Zicao on high-fat diet-induced nonalcoholic fatty liver disease in rats. | 2020 | Details |
| A03782 | 33865898 | Metabolism | Collagen β(1-O) galactosyltransferase 2 deficiency contributes to lipodystrophy and aggravates NAFLD related to HMW adiponectin in mice. | 2021 | Details |
| A03793 | 33862107 | Life Sci | Naringin improves lipid metabolism in a tissue-engineered liver model of NAFLD and the underlying mechanisms. | 2021 | Details |
| A03801 | 33860590 | Phytother Res | Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2-CREB-SIRT1 axis. | 2021 | Details |
| A03834 | 33853848 | BMJ Open Diabetes Res Care | Interleukin-6 mediated exercise-induced alleviation of adiposity and hepatic steatosis in mice. | 2021 | Details |
| A03872 | 33838175 | Food Chem Toxicol | Increased toxicity and retention of perflourooctane sulfonate (PFOS) in humanized CYP2B6-Transgenic mice compared to Cyp2b-null mice is relieved by a high-fat diet (HFD). | 2021 | Details |
| A03893 | 33830112 | Mymensingh Med J | Study on Alanine Aminotransferase in Patients of Type 2 Diabetes Mellitus. | 2021 | Details |
| A03934 | 33813455 | Wiad Lek | 13C-METHACETIN BREATHE TEST IN EARLY DIAGNOSTICS OF NON-ALCOHOLIC FATTY LIVER DISEASE. | 2021 | Details |
| A03942 | 33811367 | Hepatology | Saroglitazar, a PPAR-α/γ Agonist, for Treatment of NAFLD: A Randomized Controlled Double-Blind Phase 2 Trial. | 2021 | Details |
| A03943 | 33811139 | Proc Natl Acad Sci U S A | Active p38α causes macrovesicular fatty liver in mice. | 2021 | Details |
| A03952 | 33809593 | Nutrients | Fortifying Butterfat with Soybean Oil Attenuates the Onset of Diet-Induced Non-Alcoholic Steatohepatitis and Glucose Intolerance. | 2021 | Details |
| A03958 | 33808007 | Int J Mol Sci | Momordica cochinchinensis Aril Ameliorates Diet-Induced Metabolic Dysfunction and Non-Alcoholic Fatty Liver by Modulating Gut Microbiota. | 2021 | Details |
| A03982 | 33802455 | Nutrients | Fructo-Oligosaccharides and Pectins Enhance Beneficial Effects of Raspberry Polyphenols in Rats with Nonalcoholic Fatty Liver. | 2021 | Details |
| A03992 | 33799862 | Int J Mol Sci | A Scoping Review on Lipocalin-2 and Its Role in Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma. | 2021 | Details |
| A03993 | 33798787 | Cell Mol Gastroenterol Hepatol | Hypoxia via ERK Signaling Inhibits Hepatic PPARα to Promote Fatty Liver. | 2021 | Details |
| A04000 | 33794741 | Autophagy | The ménage à trois of autophagy, lipid droplets and liver disease. | 2021 | Details |
| A04012 | 33789150 | J Nutr Biochem | The transcription factors CREBH, PPARa, and FOXO1 as critical hepatic mediators of diet-induced metabolic dysregulation. | 2021 | Details |
| A04014 | 33788569 | J Nat Prod | Diverse Polycyclic Polyprenylated Acylphloroglucinol Congeners with Anti-Nonalcoholic Steatohepatitis Activity from Hypericum forrestii. | 2021 | Details |
| A04016 | 33788377 | Liver Int | Elafibranor and liraglutide improve differentially liver health and metabolism in a mouse model of non-alcoholic steatohepatitis. | 2021 | Details |
| A04044 | 33777700 | Toxicol Rep | Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis. | 2021 | Details |
| A04045 | 33777674 | Acta Pharm Sin B | S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling. | 2020 | Details |
| A04053 | 33775782 | Food Chem Toxicol | Investigation of steatosis profiles induced by pesticides using liver organ-on-chip model and omics analysis. | 2021 | Details |
| A04064 | 33772116 | Commun Biol | INPP4B protects from metabolic syndrome and associated disorders. | 2021 | Details |
| A04111 | 33753108 | Eur J Pharmacol | Hepatoprotective effect of selected isoandrographolide derivatives on steatotic HepG2 cells and High Fat Diet fed rats. | 2021 | Details |
| A04128 | 33746742 | Front Pharmacol | Liraglutide Alleviates Hepatic Steatosis and Liver Injury in T2MD Rats via a GLP-1R Dependent AMPK Pathway. | 2021 | Details |
| A04142 | 33743323 | Nutr Res | Severity of metabolic syndrome is greater among nonalcoholic adults with elevated ALT and advanced fibrosis. | 2020 | Details |
| A04159 | 33734012 | Autophagy | MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism. | 2021 | Details |
| A04160 | 33733575 | Biofactors | Quercetin prevents cadmium chloride-induced hepatic steatosis and fibrosis by downregulating the transcription of miR-21. | 2021 | Details |
| A04179 | 33726778 | Chin Med | Hepatoprotective effect of Qushihuayu formula on non-alcoholic steatohepatitis induced by MCD diet in rat. | 2021 | Details |
| A04190 | 33722154 | Adipocyte | Dysfunctional adiposity index as a marker of adipose tissue morpho-functional abnormalities and metabolic disorders in apparently healthy subjects. | 2021 | Details |
| A04195 | 33720570 | Ter Arkh | [Clinical and prognostic value of metabolic disorders in non-alcoholic fatty liver disease]. | 2020 | Details |
| A04230 | 33705952 | J Nutr Biochem | n-3 PUFAs protect against adiposity and fatty liver by promoting browning in postnatally overfed male rats: a role for NRG4. | 2021 | Details |
| A04296 | 33673073 | Int J Mol Sci | Effect of Chronic Western Diets on Non-Alcoholic Fatty Liver of Male Mice Modifying the PPAR-γ Pathway via miR-27b-5p Regulation. | 2021 | Details |
| A04308 | 33671486 | Molecules | Influence of Genistein on Hepatic Lipid Metabolism in an In Vitro Model of Hepatic Steatosis. | 2021 | Details |
| A04315 | 33668153 | Cancers (Basel) | MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF-β, and STAT3 Signaling. | 2021 | Details |
| A04338 | 33658534 | Sci Rep | Beneficial effects of elafibranor on NASH in E3L.CETP mice and differences between mice and men. | 2021 | Details |
| A04352 | 33652261 | Biomed Pharmacother | Akebia saponin D ameliorates metabolic syndrome (MetS) via remodeling gut microbiota and attenuating intestinal barrier injury. | 2021 | Details |
| A04386 | 33639194 | Eur J Pharmacol | Research progress in use of traditional Chinese medicine monomer for treatment of non-alcoholic fatty liver disease. | 2021 | Details |
| A04469 | 33603948 | Oxid Med Cell Longev | Bixin Attenuates High-Fat Diet-Caused Liver Steatosis and Inflammatory Injury through Nrf2/PPARα Signals. | 2021 | Details |
| A04473 | 33603714 | Front Endocrinol (Lausanne) | Integrated Analysis of Key Genes and Pathways Involved in Nonalcoholic Steatohepatitis Improvement After Roux-en-Y Gastric Bypass Surgery. | 2021 | Details |
| A04512 | 33592910 | Medicine (Baltimore) | Association of non-alcoholic fatty liver disease and all-cause mortality in hospitalized cardiovascular disease patients: A systematic review and meta-analysis. | 2021 | Details |
| A04538 | 33584545 | Front Endocrinol (Lausanne) | TLR9 in MAFLD and NASH: At the Intersection of Inflammation and Metabolism. | 2021 | Details |
| A04552 | 33581653 | Biomed Pharmacother | Danthron ameliorates obesity and MAFLD through activating the interplay between PPARα/RXRα heterodimer and adiponectin receptor 2. | 2021 | Details |
| A04558 | 33580458 | Mol Biol Rep | Evaluating the effect of a mixture of two main conjugated linoleic acid isomers on hepatic steatosis in HepG2 cellular model. | 2021 | Details |
| A04567 | 33578449 | Biotechnol Appl Biochem | An insight into the role of telmisartan as PPAR-γ/α dual activator in the management of nonalcoholic fatty liver disease. | 2021 | Details |
| A04604 | 33566371 | FASEB J | NUPR1 protects liver from lipotoxic injury by improving the endoplasmic reticulum stress response. | 2021 | Details |
| A04630 | 33557317 | Metabolites | A Study of Blood Fatty Acids Profile in Hyperlipidemic and Normolipidemic Subjects in Association with Common PNPLA3 and ABCB1 Polymorphisms. | 2021 | Details |
| A04636 | 33555523 | J Gastrointest Surg | Gastric Bypass Increases Circulating Bile Acids and Activates Hepatic Farnesoid X Receptor (FXR) but Requires Intact Peroxisome Proliferator Activator Receptor Alpha (PPARα) Signaling to Significantly Reduce Liver Fat Content. | 2021 | Details |
| A04667 | 33546405 | Nutrients | Effects of Long-Term DHA Supplementation and Physical Exercise on Non-Alcoholic Fatty Liver Development in Obese Aged Female Mice. | 2021 | Details |
| A04671 | 33546051 | Medicine (Baltimore) | Comparative efficacy and safety of traditional Chinese patent medicine for NAFLD in childhood or adolescence: A protocol for a Bayesian network meta analysis. | 2021 | Details |
| A04673 | 33545430 | Cell Mol Gastroenterol Hepatol | Transcriptional Regulation of Metabolic Pathways via Lipid-Sensing Nuclear Receptors PPARs, FXR, and LXR in NASH. | 2021 | Details |
| A04674 | 33545428 | Cell Mol Gastroenterol Hepatol | SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A04700 | 33535836 | Expert Rev Clin Pharmacol | An update on drug development for the treatment of nonalcoholic fatty liver disease - from ongoing clinical trials to future therapy. | 2021 | Details |
| A04721 | 33529448 | Liver Int | Maternal high-fat diet disrupted one-carbon metabolism in offspring, contributing to nonalcoholic fatty liver disease. | 2021 | Details |
| A04731 | 33524747 | Chemosphere | Thiamethoxam induces nonalcoholic fatty liver disease in mice via methionine metabolism disturb via nicotinamide N-methyltransferase overexpression. | 2021 | Details |
| A04804 | 33500241 | J Lipid Res | Mutation in the distal NPxY motif of LRP1 alleviates dietary cholesterol-induced dyslipidemia and tissue inflammation. | 2020 | Details |
| A04827 | 33492440 | Eur J Pediatr | The triglycerides and glucose index is strongly associated with hepatic steatosis in children with overweight or obesity. | 2021 | Details |
| A04828 | 33491665 | JCI Insight | Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease. | 2021 | Details |
| A04844 | 33486695 | Arch Pharm Res | Inhibition of hyaluronan synthesis by 4-methylumbelliferone ameliorates non-alcoholic steatohepatitis in choline-deficient L-amino acid-defined diet-induced murine model. | 2021 | Details |
| A04849 | 33485064 | Biomed Pharmacother | Crosstalk between PPARs and gut microbiota in NAFLD. | 2021 | Details |
| A04853 | 33482185 | Life Sci | Beinaglutide shows significantly beneficial effects in diabetes/obesity-induced nonalcoholic steatohepatitis in ob/ob mouse model. | 2021 | Details |
| A04858 | 33479187 | J Obes Metab Syndr | Anti-Obesity Effects of Artemisia annua Extract in Zucker Fatty Rats and High-Fat Diet Sprague Dawley Rats through Upregulation of Uncoupling Protein 1. | 2021 | Details |
| A04870 | 33474802 | Pharmacol Res Perspect | Dexmedetomidine ameliorates high-fat diet-induced nonalcoholic fatty liver disease by targeting SCD1 in obesity mice. | 2021 | Details |
| A04884 | 33467546 | Int J Mol Sci | Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in High Fat Diet Fed ApoE(-/-) Mice by Activating Autophagy and Reducing ER Stress and Apoptosis. | 2021 | Details |
| A04916 | 33450094 | J Physiol | Exposure to high fructose corn syrup during adolescence in the mouse alters hepatic metabolism and the microbiome in a sex-specific manner. | 2021 | Details |
| A04917 | 33449950 | PLoS One | Palmitate induces fat accumulation via repressing FoxO1-mediated ATGL-dependent lipolysis in HepG2 hepatocytes. | 2021 | Details |
| A04925 | 33446707 | Sci Rep | The potential ameliorative impacts of cerium oxide nanoparticles against fipronil-induced hepatic steatosis. | 2021 | Details |
| A04933 | 33444819 | Cell Mol Gastroenterol Hepatol | Hepatocyte-Specific Loss of PPARγ Protects Mice From NASH and Increases the Therapeutic Effects of Rosiglitazone in the Liver. | 2021 | Details |
| A04937 | 33444606 | Metabolism | Elafibranor improves diet-induced nonalcoholic steatohepatitis associated with heart failure with preserved ejection fraction in Golden Syrian hamsters. | 2021 | Details |
| A04951 | 33439102 | Am J Physiol Gastrointest Liver Physiol | Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling. | 2021 | Details |
| A04982 | 33426569 | J Med Syst | Non-alcoholic Fatty Liver and Liver Fibrosis Predictive Analytics: Risk Prediction and Machine Learning Techniques for Improved Preventive Medicine. | 2021 | Details |
| A04984 | 33425805 | Can J Gastroenterol Hepatol | Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A04989 | 33422644 | Mol Metab | Neonatal overfeeding during lactation rapidly and permanently misaligns the hepatic circadian rhythm and programmes adult NAFLD. | 2021 | Details |
| A05002 | 33417961 | Life Sci | Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity. | 2021 | Details |
| A05005 | 33415161 | Biomed Res Int | Identify Molecular Mechanisms of Jiangzhi Decoction on Nonalcoholic Fatty Liver Disease by Network Pharmacology Analysis and Experimental Validation. | 2020 | Details |
| A05011 | 33411880 | Food Funct | Berbamine induced activation of the SIRT1/LKB1/AMPK signaling axis attenuates the development of hepatic steatosis in high-fat diet-induced NAFLD rats. | 2021 | Details |
| A05029 | 33404166 | Int J Clin Pract | The association of the adipokine zinc-alpha2-glycoprotein with non-alcoholic fatty liver disease and related risk factors: A comprehensive systematic review. | 2021 | Details |
| A05043 | 33396939 | Int J Mol Sci | Deletion of KLF10 Leads to Stress-Induced Liver Fibrosis upon High Sucrose Feeding. | 2020 | Details |
| A05045 | 33396456 | Antioxidants (Basel) | Antioxidant and Hypolipidemic Activity of Açai Fruit Makes It a Valuable Functional Food. | 2020 | Details |
| A05052 | 33392801 | Curr Atheroscler Rep | Selective Peroxisome Proliferator-Activated Receptor Alpha Modulators (SPPARMα) in the Metabolic Syndrome: Is Pemafibrate Light at the End of the Tunnel? | 2021 | Details |
| A05060 | 33390979 | Front Pharmacol | Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate. | 2020 | Details |
| A05064 | 33390398 | J Nutr Sci Vitaminol (Tokyo) | Gene Expression and Histochemical Analyses in the Fatty Livers of Rats Fed a Histidine-Excess Diet. | 2020 | Details |
| A05067 | 33388954 | Pediatr Surg Int | The administration of hepatocyte growth factor prevents total parenteral nutrition-induced hepatocellular injury in a rat model. | 2021 | Details |
| A05128 | 33363046 | Front Cell Infect Microbiol | E. coli NF73-1 Isolated From NASH Patients Aggravates NAFLD in Mice by Translocating Into the Liver and Stimulating M1 Polarization. | 2020 | Details |
| A05133 | 33361348 | Gut | RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease. | 2020 | Details |
| A05137 | 33359401 | Mol Metab | Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease. | 2020 | Details |
| A05154 | 33352441 | Int Immunopharmacol | Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses. | 2020 | Details |
| A05180 | 33345314 | J Cell Physiol | Ghrelin ameliorates nonalcoholic steatohepatitis induced by chronic low-grade inflammation via blockade of Kupffer cell M1 polarization. | 2020 | Details |
| A05207 | 33339155 | Antioxidants (Basel) | N-Acetyl Cysteine Targets Hepatic Lipid Accumulation to Curb Oxidative Stress and Inflammation in NAFLD: A Comprehensive Analysis of the Literature. | 2020 | Details |
| A05245 | 33326461 | PLoS One | The pharmacodynamic and differential gene expression analysis of PPAR α/δ agonist GFT505 in CDAHFD-induced NASH model. | 2020 | Details |
| A05246 | 33325949 | Food Funct | Taxifolin ameliorate high-fat-diet feeding plus acute ethanol binge-induced steatohepatitis through inhibiting inflammatory caspase-1-dependent pyroptosis. | 2020 | Details |
| A05283 | 33312933 | Health Promot Perspect | Effects of oleoylethanolamide supplementation on atherogenic indices and hematological parameters in patients with nonalcoholic fatty liver disease: A clinical trial. | 2020 | Details |
| A05287 | 33312420 | World J Hepatol | Inhibition of vascular adhesion protein-1 modifies hepatic steatosis in vitro and in vivo. | 2020 | Details |
| A05294 | 33310034 | Life Sci | Aerobic training improves NAFLD markers and insulin resistance through AMPK-PPAR-α signaling in obese mice. | 2020 | Details |