Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A29976 | 33178326 | Evid Based Complement Alternat Med | Efficacy and Mechanism of a Chinese Classic Prescription of Yueju in Treating Nonalcoholic Steatohepatitis and Protecting Hepatocytes from Apoptosis. | 2020 | Details |
| A30072 | 33022884 | J Diabetes | Integrative analysis of hepatic metabolomic and transcriptomic data reveals potential mechanism of nonalcoholic steatohepatitis in high-fat diet-fed mice. | 2020 | Details |
| A30130 | 32937969 | Biomedicines | Mitochondrial Transfer by Human Mesenchymal Stromal Cells Ameliorates Hepatocyte Lipid Load in a Mouse Model of NASH. | 2020 | Details |
| A30134 | 32923834 | Hepatol Commun | The Selective Peroxisome Proliferator-Activated Receptor Gamma Modulator CHS-131 Improves Liver Histopathology and Metabolism in a Mouse Model of Obesity and Nonalcoholic Steatohepatitis. | 2020 | Details |
| A30237 | 32764725 | Nat Rev Endocrinol | The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic. | 2020 | Details |
| A30300 | 32682196 | Eur J Med Chem | A novel long-acting oxyntomodulin analogue eliminates diabetes and obesity in mice. | 2020 | Details |
| A30344 | 32612285 | Lab Invest | Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice. | 2020 | Details |
| A30480 | 32377219 | Nutr Metab (Lond) | Gypenosides regulate farnesoid X receptor-mediated bile acid and lipid metabolism in a mouse model of non-alcoholic steatohepatitis. | 2020 | Details |
| A30519 | 32291331 | J Lipid Res | Dietary plant stanol ester supplementation reduces peripheral symptoms in a mouse model of Niemann-Pick type C1 disease. | 2020 | Details |
| A30665 | 32025605 | Hepatol Commun | Icosabutate Exerts Beneficial Effects Upon Insulin Sensitivity, Hepatic Inflammation, Lipotoxicity, and Fibrosis in Mice. | 2019 | Details |
| A30666 | 32025163 | J Clin Exp Hepatol | Characterisation of the Serum Metabolic Signature of Cholangiocarcinoma in a United Kingdom Cohort. | 2019 | Details |
| A30670 | 32021639 | Nutr Metab (Lond) | Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis. | 2020 | Details |
| A30836 | 31703613 | BMC Mol Biol | PSMD1 and PSMD2 regulate HepG2 cell proliferation and apoptosis via modulating cellular lipid droplet metabolism. | 2019 | Details |
| A31018 | 31388630 | Hepatol Commun | Lipoprotein Lipase Up-regulation in Hepatic Stellate Cells Exacerbates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice. | 2019 | Details |
| A31161 | 31120771 | FASEB J | Betaine attenuates pathology by stimulating lipid oxidation in liver and regulating phospholipid metabolism in brain of methionine-choline-deficient rats. | 2019 | Details |
| A31250 | 30962742 | Yonago Acta Med | Protective Effects of Ipragliflozin, a Sodium-glucose Cotransporter 2 Inhibitor, on a Non-alcoholic Steatohepatitis Mouse Model. | 2019 | Details |
| A31251 | 30962734 | J Ginseng Res | Fermented ginseng, GBCK25, ameliorates steatosis and inflammation in nonalcoholic steatohepatitis model. | 2017 | Details |
| A31285 | 30893110 | Curr Opin Lipidol | Fibroblast growth factors in control of lipid metabolism: from biological function to clinical application. | 2019 | Details |
| A31314 | 30813339 | Nutrients | Interesterified Fats Induce Deleterious Effects on Adipose Tissue and Liver in LDLr-KO Mice. | 2019 | Details |
| A31322 | 30802511 | Life Sci | The effect of enterolactone on liver lipid precursors of inflammation. | 2019 | Details |
| A31375 | 30705600 | Diabetes Metab Syndr Obes | Effects of duodenal-jejunal bypass surgery in ameliorating nonalcoholic steatohepatitis in diet-induced obese rats. | 2019 | Details |
| A31583 | 30248539 | Biomed Pharmacother | Effect of silibinin on CFLAR-JNK pathway in oleic acid-treated HepG2 cells. | 2018 | Details |
| A31619 | 30186272 | Front Microbiol | Butyrate Protects Mice Against Methionine-Choline-Deficient Diet-Induced Non-alcoholic Steatohepatitis by Improving Gut Barrier Function, Attenuating Inflammation and Reducing Endotoxin Levels. | 2018 | Details |
| A31684 | 30046568 | Hepatobiliary Surg Nutr | A fermented mixed tea made with camellia (Camellia japonica) and third-crop green tea leaves prevents nonalcoholic steatohepatitis in Sprague-Dawley rats fed a high-fat and high-cholesterol diet. | 2018 | Details |
| A31806 | 29780857 | Technology (Singap World Sci) | Multi-omic network-based interrogation of rat liver metabolism following gastric bypass surgery featuring SWATH proteomics. | 2017 | Details |
| A31933 | 29527177 | Front Physiol | Key Inflammatory Processes in Human NASH Are Reflected in Ldlr-/-.Leiden Mice: A Translational Gene Profiling Study. | 2018 | Details |
| A31981 | 29404476 | Hepatol Commun | The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis. | 2017 | Details |
| A32019 | 30906835 | Genes Dis | Neonatal overfeeding in mice aggravates the development of methionine and choline-deficient diet-induced steatohepatitis in adulthood. | 2018 | Details |
| A32082 | 29234397 | Evid Based Complement Alternat Med | Artemisia iwayomogi plus Curcuma longa Synergistically Ameliorates Nonalcoholic Steatohepatitis in HepG2 Cells. | 2017 | Details |
| A32308 | 28740538 | Evid Based Complement Alternat Med | Linarin Enriched Extract Attenuates Liver Injury and Inflammation Induced by High-Fat High-Cholesterol Diet in Rats. | 2017 | Details |
| A32411 | 28511439 | J Clin Diagn Res | Light Chain Myeloma induced Severe Hypertriglyceridemia. | 2017 | Details |
| A32879 | 27182456 | J Clin Cell Immunol | Role of Serum Biomarkers in Early Detection of Non-Alcoholic Steatohepatitis and Fibrosis in West Virginian Children. | 2016 | Details |
| A32923 | 27083546 | Poult Sci | Expression and methylation of microsomal triglyceride transfer protein and acetyl-CoA carboxylase are associated with fatty liver syndrome in chicken. | 2016 | Details |
| A33140 | 26610473 | Int J Mol Sci | Inhibitory Effect of Gardenoside on Free Fatty Acid-Induced Steatosis in HepG2 Hepatocytes. | 2015 | Details |
| A33163 | 26576191 | Evid Based Complement Alternat Med | Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats. | 2015 | Details |
| A33261 | 26344107 | Chem Phys Lipids | Recent progress in the discovery and development of stearoyl CoA desaturase inhibitors. | 2015 | Details |
| A33443 | 25977701 | Evid Based Complement Alternat Med | Metabolomics profiling to investigate the pharmacologic mechanisms of berberine for the treatment of high-fat diet-induced nonalcoholic steatohepatitis. | 2015 | Details |
| A33517 | 25826083 | Oncotarget | PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis. | 2015 | Details |
| A33583 | 25654228 | Int J Mol Sci | Reduction of oxidative stress attenuates lipoapoptosis exacerbated by hypoxia in human hepatocytes. | 2015 | Details |
| A33638 | 25537773 | Curr Gene Ther | miR-122 is a unique molecule with great potential in diagnosis, prognosis of liver disease, and therapy both as miRNA mimic and antimir. | 2015 | Details |
| A33643 | 25532502 | Dig Dis Sci | Curcumin targets multiple pathways to halt hepatic stellate cell activation: updated mechanisms in vitro and in vivo. | 2014 | Details |
| A33676 | 25448926 | Gastroenterology | Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice. | 2014 | Details |
| A33693 | 25399406 | Arch Toxicol | Toxicogenomics directory of chemically exposed human hepatocytes. | 2014 | Details |
| A33839 | 25038800 | BMC Complement Altern Med | Anti-lipoapoptotic effect of Artemisia capillaris extract on free fatty acids-induced HepG2 cells. | 2014 | Details |
| A33935 | 24827559 | Hepatol Res | High-fat and high-cholesterol diet rapidly induces non-alcoholic steatohepatitis with advanced fibrosis in Sprague-Dawley rats. | 2014 | Details |
| A33951 | 24793484 | Biochimie | ApoA-I or ABCA1 expression suppresses fatty acid synthesis by reducing 27-hydroxycholesterol levels. | 2014 | Details |
| A34043 | 24570955 | Hepatobiliary Surg Nutr | Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats. | 2013 | Details |
| A34199 | 24145238 | Lab Invest | A novel mouse model of nonalcoholic steatohepatitis with significant insulin resistance. | 2013 | Details |
| A34229 | 24021426 | J Hepatol | Serum FGF21 increases with hepatic fat accumulation in pediatric onset intestinal failure. | 2013 | Details |
| A34237 | 23996730 | Hepatology | Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice. | 2013 | Details |
| A34246 | 23978712 | J Hepatol | Hepatitis C virus modulates lipid regulatory factor Angiopoietin-like 3 gene expression by repressing HNF-1α activity. | 2013 | Details |
| A34247 | 23974795 | Mol Pharmacol | Ursodeoxycholyl lysophosphatidylethanolamide inhibits lipoapoptosis by shifting fatty acid pools toward monosaturated and polyunsaturated fatty acids in mouse hepatocytes. | 2013 | Details |
| A34278 | 23877747 | Nutr Diabetes | Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury. | 2013 | Details |
| A34280 | 23872024 | Free Radic Biol Med | Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis. | 2013 | Details |
| A34486 | 23339067 | Hepatology | Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents. | 2013 | Details |
| A34504 | 23294302 | J Toxicol Environ Health A | Polybrominated diphenyl ethers alter hepatic phosphoenolpyruvate carboxykinase enzyme kinetics in male Wistar rats: implications for lipid and glucose metabolism. | 2013 | Details |
| A34581 | 23149694 | Genes Nutr | Time-dependent network analysis reveals molecular targets underlying the development of diet-induced obesity and non-alcoholic steatohepatitis. | 2012 | Details |
| A34583 | 23147115 | Int J Obes (Lond) | Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects. | 2012 | Details |
| A34615 | 23056165 | PLoS One | Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism. | 2012 | Details |
| A35179 | 21519329 | Lab Invest | Oncostatin M produced in Kupffer cells in response to PGE2: possible contributor to hepatic insulin resistance and steatosis. | 2011 | Details |
| A35212 | 21435125 | Hepatol Res | Splenectomy reduces fibrosis and preneoplastic lesions with increased triglycerides and essential fatty acids in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. | 2011 | Details |
| A35386 | 20849909 | Food Chem Toxicol | Clerodendron glandulosum.Coleb extract ameliorates high fat diet/fatty acid induced lipotoxicity in experimental models of non-alcoholic steatohepatitis. | 2010 | Details |
| A35434 | 20683968 | Hepatology | Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. | 2010 | Details |
| A35453 | 20625232 | J Oleo Sci | Effects of docosahexaenoic acid in an experimental rat model of nonalcoholic steatohepatitis. | 2010 | Details |
| A35472 | 20566747 | Am J Pathol | Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice. | 2010 | Details |
| A35545 | 20385201 | Biochimie | Suppression of ABCA1 by unsaturated fatty acids leads to lipid accumulation in HepG2 cells. | 2010 | Details |
| A35552 | 20376096 | Gene Ther | PPARgamma is essential for protection against nonalcoholic steatohepatitis. | 2010 | Details |
| A35570 | 20347818 | Gastroenterology | Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. | 2010 | Details |
| A35603 | 20167877 | Am J Physiol Gastrointest Liver Physiol | Serum proteomic analysis of diet-induced steatohepatitis and metabolic syndrome in the Ossabaw miniature swine. | 2010 | Details |
| A35709 | 19856260 | Exp Clin Endocrinol Diabetes | Chronic acetonemia alters liver oxidative balance and lipid content in rats. A model of NASH? | 2009 | Details |
| A35799 | 19670459 | Hepatology | Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis. | 2009 | Details |
| A35865 | 19539747 | Free Radic Biol Med | Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha. | 2009 | Details |
| A36027 | 19162361 | J Hepatol | Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. | 2008 | Details |
| A36089 | 19030170 | Hepatology | Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression. | 2008 | Details |
| A36118 | 18984468 | Clin Liver Dis | Disease-specific mechanisms of fibrosis: hepatitis C virus and nonalcoholic steatohepatitis. | 2008 | Details |
| A36141 | 18948497 | J Pharmacol Exp Ther | Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet. | 2008 | Details |
| A36145 | 18941143 | J Lipid Res | The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress. | 2008 | Details |
| A36253 | 18636507 | IUBMB Life | Thioredoxin and thioredoxin binding protein 2 in the liver. | 2008 | Details |
| A36341 | 18408102 | Gut | Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis. | 2008 | Details |
| A36345 | 18397235 | Liver Int | Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis. | 2008 | Details |
| A36469 | 18063353 | Nutr Metab Cardiovasc Dis | Molecular determinants of insulin resistance, cell apoptosis and lipid accumulation in non-alcoholic steatohepatitis. | 2007 | Details |
| A36514 | 17951222 | J Lipid Res | Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes. | 2007 | Details |
| A36534 | 17929294 | Hepatology | Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. | 2007 | Details |
| A36582 | 17690174 | Am J Physiol Gastrointest Liver Physiol | Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver. | 2007 | Details |
| A36718 | 17393512 | Hepatology | Chronic intermittent hypoxia predisposes to liver injury. | 2007 | Details |
| A36810 | 17211854 | J Cell Biochem | Fat-loaded HepG2 spheroids exhibit enhanced protection from Pro-oxidant and cytokine induced damage. | 2007 | Details |
| A36929 | 16933708 | Indian J Pathol Microbiol | Nonalcoholic steatohepatitis--a histological perspective. | 2006 | Details |
| A36991 | 16768117 | Nihon Rinsho | [Non-alcoholic steatohepatitis : pathology and pathogenesis]. | 2006 | Details |
| A36993 | 16768115 | Nihon Rinsho | [Mutation of mitochondrial DNA in patients with non-alcoholic steatohepatitis]. | 2006 | Details |
| A36996 | 16768112 | Nihon Rinsho | [Role of oxidative stress in non-alcoholic steatohepatitis]. | 2006 | Details |
| A36998 | 16768108 | Nihon Rinsho | [Mouse NASH model using retinoic acid receptor alpha]. | 2006 | Details |
| A37102 | 16470923 | Zhejiang Da Xue Xue Bao Yi Xue Ban | [Nonalcoholic steatohepatitis in obese children: the prevalence and possible mechanism]. | 2006 | Details |
| A37130 | 16406828 | Mitochondrion | Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. | 2006 | Details |
| A37187 | 16297361 | J Investig Med | Peroxisome proliferator-activated receptor alpha L162V polymorphism in nonalcoholic steatohepatitis and genotype 1 hepatitis C virus-related liver steatosis. | 2005 | Details |
| A37220 | 16231364 | Hepatology | Adipokines in NASH: postprandial lipid metabolism as a link between adiponectin and liver disease. | 2005 | Details |
| A37238 | 16198619 | Hepatol Res | Thiazolidinediones: Pleiotropic drugs with potent anti-inflammatory properties for tissue protection. | 2005 | Details |
| A37282 | 16075645 | Klin Med (Mosk) | [Some parameters of carbohydrate and lipid metabolism in patients with non-alcoholic steatohepatitis]. | 2005 | Details |
| A37360 | 15868369 | J Gastroenterol | Metabolic aspects of hepatitis C viral infection: steatohepatitis resembling but distinct from NASH. | 2005 | Details |
| A37377 | 15828240 | Nihon Rinsho | [Role of PPARs in the pathophysiology of nonalcoholoic fatty liver disease]. | 2005 | Details |
| A37399 | 15770222 | Eur J Clin Nutr | Effects of oligofructose on glucose and lipid metabolism in patients with nonalcoholic steatohepatitis: results of a pilot study. | 2005 | Details |