Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Fructose1035 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A09859 | 31589122 | Curr Drug Targets | Natural Aldose Reductase Inhibitor: A Potential Therapeutic Agent for Non-alcoholic Fatty Liver Disease. | 2020 | Details |
| A09876 | 31578240 | Sci Transl Med | Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates. | 2019 | Details |
| A09918 | 31560861 | Can J Physiol Pharmacol | β-Sitosterol mitigates the development of high-fructose diet-induced nonalcoholic fatty liver disease in growing male Sprague-Dawley rats. | 2019 | Details |
| A09924 | 31558860 | World J Gastroenterol | Regulatory effect of a Chinese herbal medicine formula on non-alcoholic fatty liver disease. | 2019 | Details |
| A09939 | 31553663 | Am J Physiol Regul Integr Comp Physiol | Sex modifies the consequences of extended fructose consumption on liver health, motor function, and physiological damage in rats. | 2019 | Details |
| A09952 | 31545283 | Biomed Pharmacother | Gypenosides improve the intestinal microbiota of non-alcoholic fatty liver in mice and alleviate its progression. | 2019 | Details |
| A09956 | 31543682 | World J Gastroenterol | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source. | 2019 | Details |
| A10020 | 31522189 | Am J Case Rep | Sugar and the Mosaic of Autoimmunity. | 2019 | Details |
| A10049 | 31514051 | Redox Biol | Carbon monoxide releasing molecule-A1 improves nonalcoholic steatohepatitis via Nrf2 activation mediated improvement in oxidative stress and mitochondrial function. | 2019 | Details |
| A10054 | 31510077 | Nutrients | A Low Iron Diet Protects from Steatohepatitis in a Mouse Model. | 2019 | Details |
| A10066 | 31504822 | Nutr Rev | Role of fruit juice in achieving the 5-a-day recommendation for fruit and vegetable intake. | 2019 | Details |
| A10105 | 31482785 | Am J Trop Med Hyg | Opisthorchis viverrini Infection Augments the Severity of Nonalcoholic Fatty Liver Disease in High-Fat/High-Fructose Diet-Fed Hamsters. | 2019 | Details |
| A10132 | 31473320 | Metab Eng | Determining contributions of exogenous glucose and fructose to de novo fatty acid and glycerol synthesis in liver and adipose tissue. | 2019 | Details |
| A10171 | 31455870 | Int J Obes (Lond) | Specific diacylglycerols generated by hepatic lipogenesis stimulate the oncogenic androgen receptor activity in male hepatocytes. | 2019 | Details |
| A10205 | 31433301 | J Hepatol | Integrin β1-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH. | 2019 | Details |
| A10240 | 31415794 | Mol Cell Endocrinol | Creosote bush-derived NDGA attenuates molecular and pathological changes in a novel mouse model of non-alcoholic steatohepatitis (NASH). | 2019 | Details |
| A10243 | 31414497 | J Sci Food Agric | Quercetin administration post-weaning attenuates high-fructose, high-cholesterol diet-induced hepatic steatosis in growing, female, Sprague Dawley rat pups. | 2019 | Details |
| A10341 | 31383290 | Tissue Cell | Azoramide ameliorates fructose-induced nonalcoholic fatty liver disease in mice. | 2019 | Details |
| A10367 | 31372694 | Naunyn Schmiedebergs Arch Pharmacol | Chrysin ameliorates nonalcoholic fatty liver disease in rats. | 2019 | Details |
| A10426 | 31341444 | Integr Med (Encinitas) | Non-Alcoholic Fatty Liver Disease, an Overview. | 2019 | Details |
| A10465 | 31325638 | Biochim Biophys Acta Mol Cell Biol Lipids | Ursodeoxycholic acid is a GPBAR1 agonist and resets liver/intestinal FXR signaling in a model of diet-induced dysbiosis and NASH. | 2019 | Details |
| A10488 | 31315223 | Nutrients | Evidence for Toxic Advanced Glycation End-Products Generated in the Normal Rat Liver. | 2019 | Details |
| A10515 | 31307427 | BMC Gastroenterol | A new method to induce nonalcoholic steatohepatitis (NASH) in mice. | 2019 | Details |
| A10523 | 31301418 | Life Sci | (5R)-5-hydroxytriptolide ameliorates liver lipid accumulation by suppressing lipid synthesis and promoting lipid oxidation in mice. | 2019 | Details |
| A10533 | 31299062 | PLoS One | AEBP1 expression increases with severity of fibrosis in NASH and is regulated by glucose, palmitate, and miR-372-3p. | 2019 | Details |
| A10744 | 31213868 | Diabetes Metab Syndr Obes | The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders. | 2019 | Details |
| A10767 | 31203627 | J Agric Food Chem | Polyphenol-Rich Loquat Fruit Extract Prevents Fructose-Induced Nonalcoholic Fatty Liver Disease by Modulating Glycometabolism, Lipometabolism, Oxidative Stress, Inflammation, Intestinal Barrier, and Gut Microbiota in Mice. | 2019 | Details |
| A10823 | 31173180 | Int J Mol Med | Excess fructose and fatty acids trigger a model of non‑alcoholic fatty liver disease progression in vitro: Protective effect of the flavonoid silybin. | 2019 | Details |
| A10833 | 31168511 | Hepatol Commun | Lipocalin-2 Protects Against Diet-Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes. | 2019 | Details |
| A10865 | 31151002 | J Mech Behav Biomed Mater | Biomechanics of cultured hepatic cells during different steatogenic hits. | 2019 | Details |
| A10895 | 31136656 | Am J Clin Nutr | Different acute effects of fructose and glucose administration on hepatic fat content. | 2019 | Details |
| A10912 | 31128886 | J Pediatr | The Role of Genetic Predisposition, Programing During Fetal Life, Family Conditions, and Post-natal Diet in the Development of Pediatric Fatty Liver Disease. | 2019 | Details |
| A10926 | 31119399 | Eur J Nutr | Non-nutritive sweeteners and their association with the metabolic syndrome and non-alcoholic fatty liver disease: a review of the literature. | 2019 | Details |
| A10927 | 31119300 | Cell Mol Life Sci | Persistent changes in liver methylation and microbiome composition following reversal of diet-induced non-alcoholic-fatty liver disease. | 2019 | Details |
| A10928 | 31117231 | Nutrients | Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation. | 2019 | Details |
| A10929 | 31116779 | PLoS One | A study on hepatopathic, dyslipidemic and immunogenic properties of fructosylated-HSA-AGE and binding of autoantibodies in sera of obese and overweight patients with fructosylated-HSA-AGE. | 2019 | Details |
| A10930 | 31115630 | Appl Microbiol Biotechnol | Lactobacillus plantarum NA136 improves the non-alcoholic fatty liver disease by modulating the AMPK/Nrf2 pathway. | 2019 | Details |
| A11010 | 31082799 | J Endocrinol | Impact of exenatide on mitochondrial lipid metabolism in mice with nonalcoholic steatohepatitis. | 2019 | Details |
| A11017 | 31081165 | Hepatology | Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice. | 2019 | Details |
| A11024 | 31078624 | Gastroenterology | Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis. | 2019 | Details |
| A11031 | 31076985 | Dig Dis Sci | Vitamin E Ameliorates Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease via Nrf2/CES1 Signaling Pathway. | 2019 | Details |
| A11105 | 31040374 | Sci Rep | Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine. | 2019 | Details |
| A11148 | 31023717 | Biol Open | Longitudinal characterization of diet-induced genetic murine models of non-alcoholic steatohepatitis with metabolic, histological, and transcriptomic hallmarks of human patients. | 2019 | Details |
| A11190 | 31005808 | Phytomedicine | Amelioration of nonalcoholic fatty liver disease by swertiamarin in fructose-fed mice. | 2018 | Details |
| A11192 | 31004828 | Cell Mol Gastroenterol Hepatol | Metabolic Targets in Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A11195 | 31004566 | Biochem Pharmacol | Telmisartan and/or chlorogenic acid attenuates fructose-induced non-alcoholic fatty liver disease in rats: Implications of cross-talk between angiotensin, the sphingosine kinase/sphingoine-1-phosphate pathway, and TLR4 receptors. | 2019 | Details |
| A11217 | 30991877 | Gut Microbes | High intake of dietary fructose in overweight/obese teenagers associated with depletion of Eubacterium and Streptococcus in gut microbiome. | 2019 | Details |
| A11234 | 30981986 | J Nutr Biochem | Western diet consumption through early life induces microvesicular hepatic steatosis in association with an altered metabolome in low birth weight Guinea pigs. | 2019 | Details |
| A11280 | 30959577 | Hepatology | Fructose Promotes Leaky Gut, Endotoxemia, and Liver Fibrosis Through Ethanol-Inducible Cytochrome P450-2E1-Mediated Oxidative and Nitrative Stress. | 2019 | Details |
| A11311 | 30944821 | J Clin Transl Hepatol | Fatty Liver Disease and Gut Microbiota: A Comprehensive Update. | 2018 | Details |
| A11312 | 30943987 | J Transl Med | Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes. | 2019 | Details |
| A11348 | 30927921 | Lipids Health Dis | The severity of rat liver injury by fructose and high fat depends on the degree of respiratory dysfunction and oxidative stress induced in mitochondria. | 2019 | Details |
| A11357 | 30924429 | Proc Nutr Soc | From sugar to liver fat and public health: systems biology driven studies in understanding non-alcoholic fatty liver disease pathogenesis. | 2019 | Details |
| A11392 | 30915409 | Clin Exp Hepatol | Allopurinol potentiates the hepatoprotective effect of metformin and vitamin E in fructose-induced fatty liver in rats. | 2019 | Details |
| A11400 | 30912307 | Physiol Rep | The long-term protective effects of neonatal administration of curcumin against nonalcoholic steatohepatitis in high-fructose-fed adolescent rats. | 2019 | Details |
| A11424 | 30901028 | J Clin Endocrinol Metab | Patients With Aldolase B Deficiency Are Characterized by Increased Intrahepatic Triglyceride Content. | 2019 | Details |
| A11433 | 30896960 | Rev Esp Enferm Dig | Metabolic characterization of two different non-alcoholic fatty liver disease pre-clinical mouse models. | 2019 | Details |
| A11463 | 30885145 | BMC Gastroenterol | The FATZO mouse, a next generation model of type 2 diabetes, develops NAFLD and NASH when fed a Western diet supplemented with fructose. | 2019 | Details |
| A11467 | 30883738 | J Physiol | Challenging metabolic tissues with fructose: tissue-specific and sex-specific responses. | 2019 | Details |
| A11478 | 30879098 | Eur J Nutr | Moderate consumption of fermented alcoholic beverages diminishes diet-induced non-alcoholic fatty liver disease through mechanisms involving hepatic adiponectin signaling in mice. | 2019 | Details |
| A11521 | 30860882 | Am J Physiol Endocrinol Metab | Transgenerational impact of maternal obesogenic diet on offspring bile acid homeostasis and nonalcoholic fatty liver disease. | 2019 | Details |
| A11556 | 30841536 | Int J Mol Sci | mTOR is a Key Protein Involved in the Metabolic Effects of Simple Sugars. | 2019 | Details |
| A11575 | 30833214 | Clin Nutr | Non-alcoholic fatty liver in hereditary fructose intolerance. | 2019 | Details |
| A11603 | 30823422 | Nutrients | Dietary Sources of Fructose and Its Association with Fatty Liver in Mexican Young Adults. | 2019 | Details |
| A11617 | 30818824 | Nutrients | A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices. | 2019 | Details |
| A11627 | 30813302 | Nutrients | The Relevance of Toxic AGEs (TAGE) Cytotoxicity to NASH Pathogenesis: A Mini-Review. | 2019 | Details |
| A11653 | 30803502 | Nutr Res | Fructose threshold for inducing organ damage in a rat model of nonalcoholic fatty liver disease. | 2018 | Details |
| A11657 | 30802722 | Nutr Res | Treatment with myo-inositol attenuates binding of the carbohydrate-responsive element-binding protein to the ChREBP-β and FASN genes in rat nonalcoholic fatty liver induced by high-fructose diet. | 2019 | Details |
| A11662 | 30798914 | Med Hypotheses | Fructose-associated hepatotoxicity indexed by the lactate dehydrogenase isoenzyme LDH-5. | 2019 | Details |
| A11700 | 30787473 | Eur J Clin Nutr | The role of dietary sugars in health: molecular composition or just calories? | 2019 | Details |
| A11701 | 30787418 | Sci Rep | Transcriptional regulation of Hepatic Stellate Cell activation in NASH. | 2019 | Details |
| A11721 | 30777418 | Rev Med Inst Mex Seguro Soc | Molecular alterations induced by fructose and its impact on metabolic diseases | 2019 | Details |
| A11759 | 30763486 | Vopr Pitan | [Effect of quercetin on morphological changes in nonalcoholic fatty liver disease in high fructose-fed rats]. | 2018 | Details |
| A11816 | 30723896 | Lipids | Molecular Characterization of Microvesicular and Macrovesicular Steatosis Shows Widespread Differences in Metabolic Pathways. | 2019 | Details |
| A11844 | 30710884 | Nutrition | No association between fruits or vegetables and non-alcoholic fatty liver disease in middle-aged men and women. | 2018 | Details |
| A11876 | 30700946 | World J Gastroenterol | Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease. | 2019 | Details |
| A11881 | 34267963 | Florence Nightingale Hemsire Derg | [Is There an Effect of Dietary Fructose on Development and Prognosis of Chronic Diseases?] | 2019 | Details |
| A11918 | 30682547 | Nutrition | Raw orange intake is associated with higher prevalence of non-alcoholic fatty liver disease in an adult population. | 2018 | Details |
| A12004 | 30651350 | J Biol Chem | Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats. | 2019 | Details |
| A12055 | 30621142 | Nutrients | Effect of Wakame and Carob Pod Snacks on Non-Alcoholic Fatty Liver Disease. | 2019 | Details |
| A12057 | 30619993 | Hepatol Commun | Childhood Fructoholism and Fructoholic Liver Disease. | 2018 | Details |
| A12076 | 30611993 | Biomed Pharmacother | Plumbagin reduces obesity and nonalcoholic fatty liver disease induced by fructose in rats through regulation of lipid metabolism, inflammation and oxidative stress. | 2019 | Details |
| A12092 | 30605883 | Redox Biol | Consumption of decaffeinated coffee protects against the development of early non-alcoholic steatohepatitis: Role of intestinal barrier function. | 2018 | Details |
| A12117 | 32864300 | Curr Pharmacol Rep | Dietary Additives and Supplements Revisited: The Fewer, the Safer for Liver and Gut Health. | 2019 | Details |
| A12195 | 30567368 | Int J Mol Sci | Effective Food Ingredients for Fatty Liver: Soy Protein β-Conglycinin and Fish Oil. | 2018 | Details |
| A12224 | 30556038 | Hepatol Commun | Perinatal Nutritional Reprogramming of the Epigenome Promotes Subsequent Development of Nonalcoholic Steatohepatitis. | 2018 | Details |
| A12271 | 30539788 | Cell Mol Gastroenterol Hepatol | Macrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis. | 2018 | Details |
| A12321 | 30516003 | Physiol Rep | Exercise training suppresses scavenger receptor CD36 expression in kupffer cells of nonalcoholic steatohepatitis model mice. | 2018 | Details |
| A12327 | 30515333 | Int J Hepatol | Relationship between Experimental Diet in Rats and Nonalcoholic Hepatic Disease: Review of Literature. | 2018 | Details |
| A12359 | 30487357 | Exp Anim | AIM-deficient mouse fed a high-trans fat, high-cholesterol diet: a new animal model for nonalcoholic fatty liver disease. | 2018 | Details |
| A12367 | 30483565 | JGH Open | Is non-alcoholic fatty liver disease a reflection of what we eat or simply how much we eat? | 2018 | Details |
| A12404 | 30469339 | Nutrients | Copper-Fructose Interactions: A Novel Mechanism in the Pathogenesis of NAFLD. | 2018 | Details |
| A12405 | 30469030 | Redox Biol | Selenium-binding protein 1 (SELENBP1) is a marker of mature adipocytes. | 2018 | Details |
| A12406 | 30468651 | Front Biosci (Landmark Ed) | Fructose at the crossroads of the metabolic syndrome and obesity epidemics. | 2019 | Details |
| A12502 | 30417996 | Pak J Biol Sci | Comparative Study of Orange and its Main Bioactive Constituents as Remedy for Non-alcoholic Fatty Liver in Rats. | 2018 | Details |
| A12570 | 30387131 | J Cell Physiol | Repression of TXNIP-NLRP3 axis restores intestinal barrier function via inhibition of myeloperoxidase activity and oxidative stress in nonalcoholic steatohepatitis. | 2018 | Details |
| A12599 | 30368556 | Eur J Nutr | Differential capability of metabolic substrates to promote hepatocellular lipid accumulation. | 2018 | Details |
| A12613 | 30363947 | Oxid Med Cell Longev | Treatment of NASH with Antioxidant Therapy: Beneficial Effect of Red Cabbage on Type 2 Diabetic Rats. | 2018 | Details |
| A12649 | 30347674 | Nutrients | Effects of Unfiltered Coffee and Bioactive Coffee Compounds on the Development of Metabolic Syndrome Components in a High-Fat-/High-Fructose-Fed Rat Model. | 2018 | Details |
| A12708 | 30318957 | Arch Physiol Biochem | High-intensity interval training (HIIT) alleviated NAFLD feature via miR-122 induction in liver of high-fat high-fructose diet induced diabetic rats. | 2018 | Details |