Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A03828 | 33855952 | Acta Medica (Hradec Kralove) | The Connection between MicroRNAs from Visceral Adipose Tissue and Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A03843 | 33851458 | Hepatology | Hepatic Fibroblast Growth Factor 21 Is Involved in Mediating Functions of Liraglutide in Mice With Dietary Challenge. | 2021 | Details |
| A03863 | 33840662 | J Oleo Sci | Coix lacryma-jobi Seed Oil Reduces Fat Accumulation in Nonalcoholic Fatty Liver Disease by Inhibiting the Activation of the p-AMPK/SePP1/apoER2 Pathway. | 2021 | Details |
| A03870 | 33838230 | J Nutr Biochem | Calcium supplementation relieves high-fat diet-induced liver steatosis by reducing energy metabolism and promoting lipolysis. | 2021 | Details |
| A03872 | 33838175 | Food Chem Toxicol | Increased toxicity and retention of perflourooctane sulfonate (PFOS) in humanized CYP2B6-Transgenic mice compared to Cyp2b-null mice is relieved by a high-fat diet (HFD). | 2021 | Details |
| A03906 | 33824122 | Pak J Pharm Sci | Antioxidant characteristics and hepatoprotective effects of a formula derived from Maydis stigma, Nelumbo nucifera and Taraxacum officinale against carbon tetrachloride-induced hepatic damage in rats. | 2020 | Details |
| A03926 | 33815655 | Oxid Med Cell Longev | Effect of Different Exercise Intensities on Hepatocyte Apoptosis in HFD-Induced NAFLD in Rats: The Possible Role of Endoplasmic Reticulum Stress through the Regulation of the IRE1/JNK and eIF2α/CHOP Signal Pathways. | 2021 | Details |
| A03929 | 33815271 | Front Endocrinol (Lausanne) | Cholesterol Accumulation as a Driver of Hepatic Inflammation Under Translational Dietary Conditions Can Be Attenuated by a Multicomponent Medicine. | 2021 | Details |
| A03930 | 33813878 | Am J Physiol Endocrinol Metab | Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis. | 2021 | Details |
| A03936 | 33813176 | Complement Ther Clin Pract | Effects of acupoint therapy on nonalcoholic fatty liver disease: A systematic review and meta-analysis. | 2021 | Details |
| A03949 | 33810079 | Biomolecules | Coupling Machine Learning and Lipidomics as a Tool to Investigate Metabolic Dysfunction-Associated Fatty Liver Disease. A General Overview. | 2021 | Details |
| A03953 | 33809062 | Mar Drugs | Fucoidan and Fucoxanthin Attenuate Hepatic Steatosis and Inflammation of NAFLD through Modulation of Leptin/Adiponectin Axis. | 2021 | Details |
| A03956 | 33808045 | Cells | Computational Hypothesis: How Intra-Hepatic Functional Heterogeneity May Influence the Cascading Progression of Free Fatty Acid-Induced Non-Alcoholic Fatty Liver Disease (NAFLD). | 2021 | Details |
| A03982 | 33802455 | Nutrients | Fructo-Oligosaccharides and Pectins Enhance Beneficial Effects of Raspberry Polyphenols in Rats with Nonalcoholic Fatty Liver. | 2021 | Details |
| A03990 | 33800465 | Metabolites | Insulin Resistance across the Spectrum of Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03993 | 33798787 | Cell Mol Gastroenterol Hepatol | Hypoxia via ERK Signaling Inhibits Hepatic PPARα to Promote Fatty Liver. | 2021 | Details |
| A04008 | 33790913 | Front Immunol | Group 3 Innate Lymphoid Cells Protect Steatohepatitis From High-Fat Diet Induced Toxicity. | 2021 | Details |
| A04014 | 33788569 | J Nat Prod | Diverse Polycyclic Polyprenylated Acylphloroglucinol Congeners with Anti-Nonalcoholic Steatohepatitis Activity from Hypericum forrestii. | 2021 | Details |
| A04020 | 33787249 | J Agric Food Chem | Malvidin-3-O-Glucoside from Blueberry Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Transcription Factor EB-Mediated Lysosomal Function and Activating the Nrf2/ARE Signaling Pathway. | 2021 | Details |
| A04045 | 33777674 | Acta Pharm Sin B | S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling. | 2020 | Details |
| A04058 | 33773656 | Food Res Int | Dietary anthocyanins as potential natural modulators for the prevention and treatment of non-alcoholic fatty liver disease: A comprehensive review. | 2021 | Details |
| A04060 | 33773192 | Phytomedicine | Si Miao Formula attenuates non-alcoholic fatty liver disease by modulating hepatic lipid metabolism and gut microbiota. | 2021 | Details |
| A04065 | 33771967 | Cell Death Dis | E3 ubiquitin ligase Grail promotes hepatic steatosis through Sirt1 inhibition. | 2021 | Details |
| A04066 | 33771899 | Cancer Res | E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment. | 2021 | Details |
| A04067 | 33771728 | Mol Metab | Ube2i deletion in adipocytes causes lipoatrophy in mice. | 2021 | Details |
| A04069 | 33771638 | J Ethnopharmacol | Molecular mechanism of Fufang Zhenzhu Tiaozhi capsule in the treatment of type 2 diabetes mellitus with nonalcoholic fatty liver disease based on network pharmacology and validation in minipigs. | 2021 | Details |
| A04097 | 33761646 | Medicine (Baltimore) | The efficacy of novel metabolic targeted agents and natural plant drugs for nonalcoholic fatty liver disease treatment: A PRISMA-compliant network meta-analysis of randomized controlled trials. | 2021 | Details |
| A04100 | 33760189 | Mol Med Rep | Silibinin improves nonalcoholic fatty liver by regulating the expression of miR‑122: An in vitro and in vivo study. | 2021 | Details |
| A04103 | 33759220 | Biofactors | Novel roles of Tsukushi in signaling pathways and multiple disease processes. | 2021 | Details |
| A04110 | 33753727 | Cell Death Dis | S-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD. | 2021 | Details |
| A04111 | 33753108 | Eur J Pharmacol | Hepatoprotective effect of selected isoandrographolide derivatives on steatotic HepG2 cells and High Fat Diet fed rats. | 2021 | Details |
| A04115 | 33751907 | J Med Food | A Comparison of Short- and Long-Term Soy Protein Isolate Intake and Its Ability to Reduce Liver Steatosis in Obese Zucker Rats Through Modifications of Genes Involved in Inflammation and Lipid Transport. | 2021 | Details |
| A04127 | 33746771 | Front Physiol | Contrasting Effects of Fasting on Liver-Adipose Axis in Alcohol-Associated and Non-alcoholic Fatty Liver. | 2021 | Details |
| A04157 | 33736456 | Antioxid Redox Signal | Sex Differences in Nonalcoholic Fatty Liver Disease: Estrogen Influence on the Liver-Adipose Tissue Crosstalk. | 2021 | Details |
| A04159 | 33734012 | Autophagy | MED1 mediator subunit is a key regulator of hepatic autophagy and lipid metabolism. | 2021 | Details |
| A04192 | 33721354 | Clin Exp Pharmacol Physiol | Sodium butyrate ameliorates non-alcoholic fatty liver disease by upregulating miR-150 to suppress CXCR4 expression. | 2021 | Details |
| A04199 | 33719959 | Curr Pharm Des | The Effect of Metformin on Aminotransferase Levels, Metabolic Parameters and Body Mass Index in Nonalcoholic Fatty Liver Disease Patients: A Metaanalysis. | 2021 | Details |
| A04216 | 33709875 | Expert Rev Gastroenterol Hepatol | Telomerase: a key player in the pathogenesis of non-alcoholic fatty liver disease? | 2021 | Details |
| A04222 | 33708919 | Ann Transl Med | Effects of earthworm extract on the lipid profile and fatty liver induced by a high-fat diet in guinea pigs. | 2021 | Details |
| A04231 | 33705945 | J Nutr Biochem | High sucrose diet-induced dysbiosis of gut microbiota promotes fatty liver and hyperlipidemia in rats. | 2021 | Details |
| A04235 | 33694195 | J Gastroenterol Hepatol | Oxidized low-density lipoprotein activates extracellular signal-regulated kinase signaling to downregulate sortilin expression in liver sinusoidal endothelial cells. | 2021 | Details |
| A04240 | 33693480 | Cardiovasc Res | Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis. | 2022 | Details |
| A04246 | 33691721 | Nutr Metab (Lond) | Integrative proteomic and lipidomic analysis of Kaili Sour Soup-mediated attenuation of high-fat diet-induced nonalcoholic fatty liver disease in a rat model. | 2021 | Details |
| A04255 | 33687678 | Methods Mol Biol | Co-Culture of Human Mesenchymal Stromal Cells and Primary Mouse Hepatocytes. | 2021 | Details |
| A04260 | 33685086 | Zhonghua Gan Zang Bing Za Zhi | [Role of 1, 25-dihydroxyvitamin D3 in liver lipid metabolism induced by methionine-choline-deficient diet in rats]. | 2021 | Details |
| A04266 | 33684693 | Biomed Pharmacother | Exploring the mechanism of PingTang No.5 capsule on nonalcoholic fatty liver disease through network pharmacology and experimental validation. | 2021 | Details |
| A04267 | 33684566 | Biochim Biophys Acta Mol Cell Biol Lipids | GDF11 rapidly increases lipid accumulation in liver cancer cells through ALK5-dependent signaling. | 2021 | Details |
| A04293 | 33674694 | Sci Rep | DSS-induced colitis is associated with adipose tissue dysfunction and disrupted hepatic lipid metabolism leading to hepatosteatosis and dyslipidemia in mice. | 2021 | Details |
| A04300 | 33672787 | Int J Mol Sci | Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice. | 2021 | Details |
| A04303 | 33671880 | Biomedicines | Immunomodulatory Role of Urolithin A on Metabolic Diseases. | 2021 | Details |
| A04305 | 33671715 | Molecules | Antioxidant and Antisteatotic Activities of a New Fucoidan Extracted from Ferula hermonis Roots Harvested on Lebanese Mountains. | 2021 | Details |
| A04307 | 33671547 | Int J Mol Sci | Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer. | 2021 | Details |
| A04308 | 33671486 | Molecules | Influence of Genistein on Hepatic Lipid Metabolism in an In Vitro Model of Hepatic Steatosis. | 2021 | Details |
| A04315 | 33668153 | Cancers (Basel) | MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF-β, and STAT3 Signaling. | 2021 | Details |
| A04318 | 33667513 | Life Sci | Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD. | 2021 | Details |
| A04320 | 33665859 | J Food Biochem | Protective effects of Dendrobium candidum Wall ex Lindl. on high-fat diet-induced liver damage in mice. | 2021 | Details |
| A04331 | 33664225 | Cell Death Dis | Hepatic HuR protects against the pathogenesis of non-alcoholic fatty liver disease by targeting PTEN. | 2021 | Details |
| A04333 | 33662773 | Clin Res Hepatol Gastroenterol | Low levels of Lysosomal Acid Lipase (LAL) activity increases necroinflammation in adult patients with biopsy-proven metabolic associated fatty liver disease. | 2021 | Details |
| A04339 | 33658485 | Cell Death Dis | WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1. | 2021 | Details |
| A04361 | 33647884 | Aging (Albany NY) | Exercise in mice ameliorates high-fat diet-induced nonalcoholic fatty liver disease by lowering HMGCS2. | 2021 | Details |
| A04362 | 33647823 | Int Immunopharmacol | The SGLT2 inhibitor empagliflozin negatively regulates IL-17/IL-23 axis-mediated inflammatory responses in T2DM with NAFLD via the AMPK/mTOR/autophagy pathway. | 2021 | Details |
| A04367 | 33647205 | Chem Res Toxicol | LXRα/β Antagonism Protects against Lipid Accumulation in the Liver but Increases Plasma Cholesterol in Rhesus Macaques. | 2021 | Details |
| A04379 | 33641283 | Crit Rev Oncog | Understanding the Alterations in Lipid Metabolism in NAFLD Progression: Current Trends and Future Directions. | 2021 | Details |
| A04380 | 33641248 | Liver Int | SPARC inhibition accelerates NAFLD-associated hepatocellular carcinoma development by dysregulating hepatic lipid metabolism. | 2021 | Details |
| A04385 | 33640247 | Phytomedicine | A network pharmacology approach: Inhibition of the NF-κB signaling pathway contributes to the NASH preventative effect of an Oroxylum indicum seed extract in oleic acid-stimulated HepG2 cells and high-fat diet-fed rats. | 2021 | Details |
| A04392 | 33637021 | Thyroid | Comparative Analysis of the Effects of Long-Term 3,5-diiodothyronine Treatment on the Murine Hepatic Proteome and Transcriptome Under Conditions of Normal Diet and High-Fat Diet. | 2021 | Details |
| A04394 | 33636349 | Pharmacol Res | Current innovations in nutraceuticals and functional foods for intervention of non-alcoholic fatty liver disease. | 2021 | Details |
| A04405 | 33631228 | J Hepatol | Targeting cell-intrinsic metabolism for antifibrotic therapy. | 2021 | Details |
| A04406 | 33630750 | Eur J Endocrinol | MECHANISMS IN ENDOCRINOLOGY: FXR signalling: a novel target in metabolic diseases. | 2021 | Details |
| A04437 | 33616158 | Biochem J | Tracking biochemical changes induced by iron loading in AML12 cells with synchrotron live cell, time-lapse infrared microscopy. | 2021 | Details |
| A04458 | 33608323 | Dis Model Mech | High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition. | 2021 | Details |
| A04469 | 33603948 | Oxid Med Cell Longev | Bixin Attenuates High-Fat Diet-Caused Liver Steatosis and Inflammatory Injury through Nrf2/PPARα Signals. | 2021 | Details |
| A04474 | 33603666 | Front Pharmacol | The Role of Bone Morphogenetic Protein 9 in Nonalcoholic Fatty Liver Disease in Mice. | 2021 | Details |
| A04477 | 33602203 | BMC Endocr Disord | Thyroid function and non-alcoholic fatty liver disease in hyperthyroidism patients. | 2021 | Details |
| A04479 | 33601216 | Nutr Res | G protein-coupled receptors: Key molecules in metabolic associated fatty liver disease development. | 2020 | Details |
| A04499 | 33596054 | Anal Chem | CD36 as a Molecular Target of Functional DNA Aptamer NAFLD01 Selected against NAFLD Cells. | 2021 | Details |
| A04515 | 33591626 | J Cell Mol Med | Mesenchymal stromal cells protect hepatocytes from lipotoxicity through alleviation of endoplasmic reticulum stress by restoring SERCA activity. | 2021 | Details |
| A04527 | 33586569 | Int J Food Sci Nutr | Reduced plasma carotenoids in individuals suffering from metabolic diseases with disturbances in lipid metabolism: a systematic review and meta-analysis of observational studies. | 2021 | Details |
| A04548 | 33582286 | Biochim Biophys Acta Mol Cell Biol Lipids | Chronic systemic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liver. | 2021 | Details |
| A04552 | 33581653 | Biomed Pharmacother | Danthron ameliorates obesity and MAFLD through activating the interplay between PPARα/RXRα heterodimer and adiponectin receptor 2. | 2021 | Details |
| A04557 | 33580500 | J Food Sci | Major royal jelly proteins prevents NAFLD by improving mitochondrial function and lipid accumulation through activating the AMPK / SIRT3 pathway in vitro. | 2021 | Details |
| A04558 | 33580458 | Mol Biol Rep | Evaluating the effect of a mixture of two main conjugated linoleic acid isomers on hepatic steatosis in HepG2 cellular model. | 2021 | Details |
| A04568 | 33578292 | Biochem Biophys Res Commun | Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1. | 2021 | Details |
| A04591 | 33571540 | Metabolism | The S100 calcium-binding protein A11 promotes hepatic steatosis through RAGE-mediated AKT-mTOR signaling. | 2021 | Details |
| A04602 | 33567543 | Nutrients | Implication between Genetic Variants from APOA5 and ZPR1 and NAFLD Severity in Patients with Hypertriglyceridemia. | 2021 | Details |
| A04604 | 33566371 | FASEB J | NUPR1 protects liver from lipotoxic injury by improving the endoplasmic reticulum stress response. | 2021 | Details |
| A04619 | 33560577 | Mol Nutr Food Res | Three Novel Dietary Phenolic Compounds from Pickled Raphanus Sativus L. Inhibit Lipid Accumulation in Obese Mice by Modulating the Gut Microbiota Composition. | 2021 | Details |
| A04623 | 33559369 | Mol Nutr Food Res | Black Current Anthocyanins Improve Lipid Metabolism and Modulate Gut Microbiota in High-Fat Diet-Induced Obese Mice. | 2021 | Details |
| A04638 | 33555112 | Liver Int | Leukocyte cell-derived chemotaxin 2 promotes the development of nonalcoholic fatty liver disease through STAT-1 pathway in mice. | 2021 | Details |
| A04658 | 33549451 | Nutr Metab Cardiovasc Dis | Apolipoprotein A5 controls fructose-induced metabolic dysregulation in mice. | 2020 | Details |
| A04660 | 33548473 | J Nutr Biochem | Tomatidine ameliorates obesity-induced nonalcoholic fatty liver disease in mice. | 2021 | Details |
| A04664 | 33548031 | Hepatol Int | How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease? | 2021 | Details |
| A04665 | 33546922 | Trends Cell Biol | Lipid Droplet Contact Sites in Health and Disease. | 2021 | Details |
| A04667 | 33546405 | Nutrients | Effects of Long-Term DHA Supplementation and Physical Exercise on Non-Alcoholic Fatty Liver Development in Obese Aged Female Mice. | 2021 | Details |
| A04685 | 33542911 | Can J Gastroenterol Hepatol | Systemic Overexpression of GDF5 in Adipocytes but Not Hepatocytes Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver in Mice. | 2021 | Details |
| A04690 | 33541129 | Exp Biol Med (Maywood) | Effect of vitamin D3 supplementation on hepatic lipid dysregulation associated with autophagy regulatory AMPK/Akt-mTOR signaling in type 2 diabetic mice. | 2021 | Details |
| A04696 | 33536590 | Sci Rep | The development of nonalcoholic steatohepatitis is subjected to breeder dependent variation in guinea pigs. | 2021 | Details |
| A04717 | 33530432 | Antioxidants (Basel) | Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy. | 2021 | Details |
| A04721 | 33529448 | Liver Int | Maternal high-fat diet disrupted one-carbon metabolism in offspring, contributing to nonalcoholic fatty liver disease. | 2021 | Details |
| A04725 | 33526807 | Lab Invest | NLRP3 deficiency did not attenuate NASH development under high fat calorie diet plus high fructose and glucose in drinking water. | 2021 | Details |