Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A12514 | 30413050 | Pharmaceuticals (Basel) | Antidiabetic Drugs in NAFLD: The Accomplishment of Two Goals at Once? | 2018 | Details |
| A12521 | 30411635 | Expert Opin Pharmacother | Present and emerging pharmacotherapies for non-alcoholic steatohepatitis in adults. | 2018 | Details |
| A12530 | 30408433 | Toxicol Appl Pharmacol | 6-gingerol ameliorates age-related hepatic steatosis: Association with regulating lipogenesis, fatty acid oxidation, oxidative stress and mitochondrial dysfunction. | 2018 | Details |
| A12531 | 30408316 | Mol Nutr Food Res | Mild Methylenetetrahydrofolate Reductase Deficiency Alters Inflammatory and Lipid Pathways in Liver. | 2018 | Details |
| A12546 | 30400205 | Int J Mol Sci | Reactive Oxygen Species Induces Lipid Droplet Accumulation in HepG2 Cells by Increasing Perilipin 2 Expression. | 2018 | Details |
| A12577 | 30381838 | J Physiol | SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding. | 2018 | Details |
| A12613 | 30363947 | Oxid Med Cell Longev | Treatment of NASH with Antioxidant Therapy: Beneficial Effect of Red Cabbage on Type 2 Diabetic Rats. | 2018 | Details |
| A12615 | 30363699 | PPAR Res | Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression. | 2018 | Details |
| A12621 | 30361013 | Food Res Int | Bacupari peel extracts (Garcinia brasiliensis) reduces the biometry, lipogenesis and hepatic steatosis in obese rats. | 2018 | Details |
| A12645 | 30352176 | Dev Cell | Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis. | 2018 | Details |
| A12656 | 30344430 | J Ginseng Res | Ginseng seed oil ameliorates hepatic lipid accumulation in vitro and in vivo. | 2017 | Details |
| A12693 | 30324559 | Cell Biochem Biophys | Melatonin Modulates lipid Metabolism in HepG2 Cells Cultured in High Concentrations of Oleic Acid: AMPK Pathway Activation may Play an Important Role. | 2018 | Details |
| A12753 | 30300835 | J Nutr Biochem | Long-term exposure to high-sucrose diet down-regulates hepatic endoplasmic reticulum-stress adaptive pathways and potentiates de novo lipogenesis in weaned male mice. | 2018 | Details |
| A12757 | 30300140 | J Clin Invest | Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration. | 2018 | Details |
| A12781 | 30291215 | Biosci Rep | The Chinese medicine Chai Hu Li Zhong Tang protects against non-alcoholic fatty liver disease by activating AMPKα. | 2018 | Details |
| A12786 | 30288476 | Hepatol Commun | Hepatic Nuclear Receptor Expression Associates with Features of Histology in Pediatric Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A12788 | 30287791 | Int J Mol Sci | Identification of a Novel PPAR-γ Agonist through a Scaffold Tuning Approach. | 2018 | Details |
| A12796 | 30284617 | J Gastroenterol | Clinical significance of hepatic steatosis according to coronary plaque morphology: assessment using controlled attenuation parameter. | 2018 | Details |
| A12800 | 30283077 | Int J Obes (Lond) | Ascorbic acid inhibits visceral obesity and nonalcoholic fatty liver disease by activating peroxisome proliferator-activated receptor α in high-fat-diet-fed C57BL/6J mice. | 2018 | Details |
| A12803 | 30281809 | Hepatology | LXRα Promotes Hepatosteatosis in Part Through Activation of MicroRNA-378 Transcription and Inhibition of Ppargc1β Expression. | 2019 | Details |
| A12807 | 30274911 | Clin Res Hepatol Gastroenterol | Association of glycated hemoglobin with the risk of advanced fibrosis in non-alcoholic fatty liver disease patients without diabetes. | 2018 | Details |
| A12811 | 30273090 | J Med Food | Aqueous Extract of Humulus japonicus Attenuates Hyperlipidemia and Fatty Liver in Obese Mice. | 2018 | Details |
| A12850 | 30257410 | Biomed Pharmacother | Curative effect of arjunolic acid from Terminalia arjuna in non-alcoholic fatty liver disease models. | 2018 | Details |
| A12883 | 30242180 | Sci Rep | HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver. | 2018 | Details |
| A12885 | 30241944 | Biochem Biophys Res Commun | Spermidine ameliorates non-alcoholic fatty liver disease through regulating lipid metabolism via AMPK. | 2018 | Details |
| A12923 | 30225267 | J Diabetes Res | Rosiglitazone Elicits an Adiponectin-Mediated Insulin-Sensitizing Action at the Adipose Tissue-Liver Axis in Otsuka Long-Evans Tokushima Fatty Rats. | 2018 | Details |
| A12946 | 30214048 | Sci Rep | Histone H3K9 demethylase JMJD2B induces hepatic steatosis through upregulation of PPARγ2. | 2018 | Details |
| A12961 | 30206765 | J Gastrointest Surg | Concomitant PPARα and FXR Activation as a Putative Mechanism of NASH Improvement after Gastric Bypass Surgery: a GEO Datasets Analysis. | 2018 | Details |
| A12974 | 30201044 | Biol Sex Differ | Sex-specific differences in hepatic steatosis in obese spontaneously hypertensive (SHROB) rats. | 2018 | Details |
| A12979 | 30198086 | J Sci Food Agric | Dietary salmon milt extracts attenuate hepatosteatosis and liver dysfunction in diet-induced fatty liver model. | 2018 | Details |
| A12983 | 30197273 | J Clin Lipidol | Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease: A double-blind, randomized, placebo-controlled study. | 2018 | Details |
| A13028 | 30174213 | Lancet Diabetes Endocrinol | Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies. | 2018 | Details |
| A13037 | 30171034 | Dis Model Mech | Idebenone and coenzyme Q10 are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases. | 2018 | Details |
| A13059 | 30158201 | J Lipid Res | Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice. | 2018 | Details |
| A13065 | 30154499 | Sci Rep | The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity. | 2018 | Details |
| A13067 | 30154382 | Int J Mol Sci | Flavonones from Penthorum chinense Ameliorate Hepatic Steatosis by Activating the SIRT1/AMPK Pathway in HepG2 Cells. | 2018 | Details |
| A13069 | 30153476 | Free Radic Biol Med | Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration. | 2018 | Details |
| A13090 | 30142454 | Free Radic Biol Med | Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state. | 2018 | Details |
| A13105 | 30135656 | Front Pharmacol | LncRNA-AK012226 Is Involved in Fat Accumulation in db/db Mice Fatty Liver and Non-alcoholic Fatty Liver Disease Cell Model. | 2018 | Details |
| A13108 | 30135326 | Biol Pharm Bull | Ginsenoside Rg1 Protects against Non-alcoholic Fatty Liver Disease by Ameliorating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammasome Activation. | 2018 | Details |
| A13113 | 30134762 | Int J Toxicol | Paradoxical Protective Effect of Perfluorooctanesulfonic Acid Against High-Fat Diet-Induced Hepatic Steatosis in Mice. | 2018 | Details |
| A13118 | 30131870 | NPJ Syst Biol Appl | Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease. | 2018 | Details |
| A13126 | 30128299 | Toxicol Rep | Comparison of transcriptome responses to glyphosate, isoxaflutole, quizalofop-p-ethyl and mesotrione in the HepaRG cell line. | 2018 | Details |
| A13137 | 30120929 | Toxicology | Modulation of xenobiotic nuclear receptors in high-fat diet induced non-alcoholic fatty liver disease. | 2018 | Details |
| A13147 | 30115876 | Molecules | Hepatoprotective Effects of MHY3200 on High-Fat, Diet-Induced, Non-Alcoholic Fatty Liver Disease in Rats. | 2018 | Details |
| A13153 | 30112518 | Curr Opin Gynecol Obstet | The Association of Hispanic Ethnicity with Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome. | 2018 | Details |
| A13169 | 30103390 | Nutrients | Delphinidin Ameliorates Hepatic Triglyceride Accumulation in Human HepG2 Cells, but Not in Diet-Induced Obese Mice. | 2018 | Details |
| A13184 | 30096951 | Nutrients | Adipocytokine Regulation and Antiangiogenic Activity Underlie the Molecular Mechanisms of Therapeutic Effects of Phyllanthus niruri against Non-Alcoholic Fatty Liver Disease. | 2018 | Details |
| A13185 | 30096384 | Life Sci | Gut inflammation exacerbates hepatic injury in the high-fat diet induced NAFLD mouse: Attention to the gut-vascular barrier dysfunction. | 2018 | Details |
| A13190 | 30092894 | J Clin Sleep Med | Continuous Positive Airway Pressure Therapy on Nonalcoholic Fatty Liver Disease in Patients With Obstructive Sleep Apnea. | 2018 | Details |
| A13193 | 30092591 | Cell Physiol Biochem | Bioactive Peptide Improves Diet-Induced Hepatic Fat Deposition and Hepatocyte Proinflammatory Response in SAMP8 Ageing Mice. | 2018 | Details |
| A13199 | 30089858 | Lab Invest | Iso-alpha acids from hops (Humulus lupulus) inhibit hepatic steatosis, inflammation, and fibrosis. | 2018 | Details |
| A13215 | 30079055 | Front Microbiol | Genetically Obese Human Gut Microbiota Induces Liver Steatosis in Germ-Free Mice Fed on Normal Diet. | 2018 | Details |
| A13316 | 30036051 | J Agric Food Chem | Cichoric Acid Prevents Free-Fatty-Acid-Induced Lipid Metabolism Disorders via Regulating Bmal1 in HepG2 Cells. | 2018 | Details |
| A13334 | 30026731 | Front Endocrinol (Lausanne) | Comparative Study of Different Diets-Induced NAFLD Models of Zebrafish. | 2018 | Details |
| A13345 | 30021122 | Pharmacol Res | Future trends in the treatment of non-alcoholic steatohepatitis. | 2018 | Details |
| A13383 | 30008738 | PPAR Res | Treatment with Lobeglitazone Attenuates Hepatic Steatosis in Diet-Induced Obese Mice. | 2018 | Details |
| A13384 | 30006580 | Int J Obes (Lond) | Zinc alpha2 glycoprotein protects against obesity-induced hepatic steatosis. | 2018 | Details |
| A13387 | 30006154 | Biochim Biophys Acta Mol Basis Dis | GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice. | 2018 | Details |
| A13431 | 29976400 | J Food Drug Anal | Tetrahydrocurcumin ameliorates free fatty acid-induced hepatic steatosis and improves insulin resistance in HepG2 cells. | 2018 | Details |
| A13461 | 29961332 | J Agric Food Chem | Sodium Butyrate Ameliorates High-Fat-Diet-Induced Non-alcoholic Fatty Liver Disease through Peroxisome Proliferator-Activated Receptor α-Mediated Activation of β Oxidation and Suppression of Inflammation. | 2018 | Details |
| A13464 | 29959418 | Lab Invest | Characterization of a murine nonalcoholic steatohepatitis model induced by high fat high calorie diet plus fructose and glucose in drinking water. | 2018 | Details |
| A13486 | 29954129 | Int J Mol Sci | Insights into the Role of PPARβ/δ in NAFLD. | 2018 | Details |
| A13534 | 29926176 | Eur J Nutr | Lack of liver steatosis in germ-free mice following hypercaloric diets. | 2018 | Details |
| A13550 | 29915740 | J Family Med Prim Care | A study on the altered glycemic and lipid parameters and prevalence of insulin resistance in nonalcoholic fatty liver disease. | 2022 | Details |
| A13627 | 29864915 | Biomed Pharmacother | Dihydrocurcumin ameliorates the lipid accumulation, oxidative stress and insulin resistance in oleic acid-induced L02 and HepG2 cells. | 2018 | Details |
| A13635 | 29860222 | Biomed Pharmacother | Acylated ghrelin induces but deacylated ghrelin prevents hepatic steatosis and insulin resistance in lean rats: Effects on DAG/ PKC/JNK pathway. | 2018 | Details |
| A13636 | 29860219 | Biomed Pharmacother | Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice. | 2018 | Details |
| A13667 | 29847571 | PLoS One | ILDR2 has a negligible role in hepatic steatosis. | 2018 | Details |
| A13697 | 29802754 | J Dig Dis | Fatty liver mediated by peroxisome proliferator-activated receptor-α DNA methylation can be reversed by a methylation inhibitor and curcumin. | 2018 | Details |
| A13715 | 29795111 | Cell Death Dis | Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development. | 2018 | Details |
| A13724 | 29790582 | Hepatology | Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents. | 2018 | Details |
| A13725 | 29789866 | Cell Mol Life Sci | Role of peroxisome proliferator-activated receptors in non-alcoholic fatty liver disease inflammation. | 2018 | Details |
| A13756 | 29772784 | Nutrients | Capsaicin in Metabolic Syndrome. | 2018 | Details |
| A13759 | 29770757 | Br J Nutr | Soya protein β-conglycinin ameliorates fatty liver and obesity in diet-induced obese mice through the down-regulation of PPARγ. | 2018 | Details |
| A13772 | 29764990 | Sci Signal | IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs. | 2018 | Details |
| A13815 | 29743925 | Evid Based Complement Alternat Med | Gynostemma pentaphyllum Attenuates the Progression of Nonalcoholic Fatty Liver Disease in Mice: A Biomedical Investigation Integrated with In Silico Assay. | 2018 | Details |
| A13855 | 29725353 | Evid Based Complement Alternat Med | Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Cucurbita moschata Extract. | 2018 | Details |
| A13867 | 29719598 | Oncotarget | Hyperandrogenism and insulin resistance contribute to hepatic steatosis and inflammation in female rat liver. | 2018 | Details |
| A13872 | 29717275 | Int J Obes (Lond) | Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers. | 2018 | Details |
| A13883 | 29710765 | Nutrients | A Vitamin E-Enriched Antioxidant Diet Interferes with the Acute Adaptation of the Liver to Physical Exercise in Mice. | 2018 | Details |
| A13885 | 29710028 | J Nutr Sci Vitaminol (Tokyo) | Vitamin D Deficiency Increases Lipogenesis and Reduces Beta-Oxidation in the Liver of Diet-Induced Obese Mice. | 2018 | Details |
| A13890 | 29706895 | Front Physiol | LiverSex Computational Model: Sexual Aspects in Hepatic Metabolism and Abnormalities. | 2018 | Details |
| A13897 | 29704577 | Food Chem Toxicol | Food-drug interaction: Anabolic steroids aggravate hepatic lipotoxicity and nonalcoholic fatty liver disease induced by trans fatty acids. | 2018 | Details |
| A13914 | 29696816 | J Dig Dis | Deletion of Smad4 reduces hepatic inflammation and fibrogenesis during nonalcoholic steatohepatitis progression. | 2018 | Details |
| A13923 | 29690611 | Int J Mol Sci | The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis. | 2018 | Details |
| A13943 | 29678641 | Biochim Biophys Acta Mol Cell Biol Lipids | Liver-directed microRNA-7a depletion induces nonalcoholic fatty liver disease by stabilizing YY1-mediated lipogenic pathways in zebrafish. | 2018 | Details |
| A13949 | 29674209 | Steroids | Possible mechanisms underlying fatty liver in a rat model of male hypogonadism: A protective role for testosterone. | 2018 | Details |
| A13975 | 29662003 | Int J Mol Sci | PPAR Agonists and Metabolic Syndrome: An Established Role? | 2018 | Details |
| A13987 | 29656250 | Environ Pollut | Exposure to environmental level phenanthrene induces a NASH-like phenotype in new born rat. | 2018 | Details |
| A14105 | 29580823 | Mol Cell Endocrinol | GW0742 (PPAR-beta agonist) attenuates hepatic endoplasmic reticulum stress by improving hepatic energy metabolism in high-fat diet fed mice. | 2018 | Details |
| A14138 | 29568101 | Int J Obes (Lond) | CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model. | 2018 | Details |
| A14146 | 29564062 | Gastroenterol Hepatol Bed Bench | Protein-protein interaction analysis of Alzheimer`s disease and NAFLD based on systems biology methods unhide common ancestor pathways. | 2018 | Details |
| A14155 | 29560749 | Artif Cells Nanomed Biotechnol | Targeted delivery of microRNA 146b mimic to hepatocytes by lactosylated PDMAEMA nanoparticles for the treatment of NAFLD. | 2018 | Details |
| A14160 | 29558390 | Int J Mol Sci | PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders. | 2018 | Details |
| A14165 | 29556076 | Sci Rep | The Nuclear Orphan Receptor Nur77 Alleviates Palmitate-induced Fat Accumulation by Down-regulating G0S2 in HepG2 Cells. | 2018 | Details |
| A14171 | 29553485 | J Clin Invest | Aortic carboxypeptidase-like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis. | 2018 | Details |
| A14172 | 29552625 | Cell Mol Gastroenterol Hepatol | Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2). | 2017 | Details |
| A14177 | 29550470 | Biochem Biophys Res Commun | PPARγ alleviated hepatocyte steatosis through reducing SOCS3 by inhibiting JAK2/STAT3 pathway. | 2018 | Details |
| A14186 | 29544992 | Mol Aspects Med | Omega-3 fatty acids and non-alcoholic fatty liver disease: Evidence of efficacy and mechanism of action. | 2018 | Details |