Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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lipogenesis1889 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A12693 | 30324559 | Cell Biochem Biophys | Melatonin Modulates lipid Metabolism in HepG2 Cells Cultured in High Concentrations of Oleic Acid: AMPK Pathway Activation may Play an Important Role. | 2018 | Details |
| A12700 | 30323174 | Eur J Clin Nutr | Determinants of ectopic liver fat in metabolic disease. | 2018 | Details |
| A12705 | 30321321 | Endocrinology | Selective Glucocorticoid Receptor Modulation Prevents and Reverses Nonalcoholic Fatty Liver Disease in Male Mice. | 2018 | Details |
| A12724 | 30315461 | Methods Mol Biol | Measuring Human Lipid Metabolism Using Deuterium Labeling: In Vivo and In Vitro Protocols. | 2019 | Details |
| A12753 | 30300835 | J Nutr Biochem | Long-term exposure to high-sucrose diet down-regulates hepatic endoplasmic reticulum-stress adaptive pathways and potentiates de novo lipogenesis in weaned male mice. | 2018 | Details |
| A12765 | 30298052 | Front Endocrinol (Lausanne) | The Antidiabetic Drug Lobeglitazone Protects Mice From Lipogenesis-Induced Liver Injury via Mechanistic Target of Rapamycin Complex 1 Inhibition. | 2018 | Details |
| A12770 | 30295789 | Endocrinology | Adult-Onset Hepatocyte GH Resistance Promotes NASH in Male Mice, Without Severe Systemic Metabolic Dysfunction. | 2018 | Details |
| A12803 | 30281809 | Hepatology | LXRα Promotes Hepatosteatosis in Part Through Activation of MicroRNA-378 Transcription and Inhibition of Ppargc1β Expression. | 2019 | Details |
| A12854 | 30256948 | Hum Mol Genet | Bezafibrate induces autophagy and improves hepatic lipid metabolism in glycogen storage disease type Ia. | 2019 | Details |
| A12856 | 30254132 | Dis Model Mech | A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis. | 2018 | Details |
| A12863 | 30250238 | Sci Rep | Human hepatic 3D spheroids as a model for steatosis and insulin resistance. | 2018 | Details |
| A12878 | 30244972 | Cell Metab | Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma. | 2018 | Details |
| A12922 | 30226474 | J Clin Invest | Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition. | 2018 | Details |
| A12932 | 30220454 | Cell | ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. | 2018 | Details |
| A12960 | 30208301 | Food Chem Toxicol | Trigonelline prevents high cholesterol and high fat diet induced hepatic lipid accumulation and lipo-toxicity in C57BL/6J mice, via restoration of hepatic autophagy. | 2018 | Details |
| A12973 | 30201876 | Nutrients | Preventive Effect of Flavonol Derivatives Abundant Sanglan Tea on Long-Term High-Fat-Diet-Induced Obesity Complications in C57BL/6 Mice. | 2018 | Details |
| A12974 | 30201044 | Biol Sex Differ | Sex-specific differences in hepatic steatosis in obese spontaneously hypertensive (SHROB) rats. | 2018 | Details |
| A12978 | 30200408 | Nutrients | Muscle Loss in Chronic Liver Diseases: The Example of Nonalcoholic Liver Disease. | 2018 | Details |
| A13009 | 30183139 | Mol Nutr Food Res | Gamma-Tocotrienol Attenuates the Hepatic Inflammation and Fibrosis by Suppressing Endoplasmic Reticulum Stress in Mice. | 2018 | Details |
| A13042 | 30168806 | J Clin Invest | Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease. | 2018 | Details |
| A13048 | 30165848 | BMC Complement Altern Med | Comparison of the main components and bioactivity of Rhus verniciflua Stokes extracts by different detoxification processing methods. | 2018 | Details |
| A13066 | 30154417 | Cell Death Dis | JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism. | 2018 | Details |
| A13090 | 30142454 | Free Radic Biol Med | Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state. | 2018 | Details |
| A13161 | 30109054 | R Soc Open Sci | Synergistic effect of eicosapentaenoic acid-enriched phospholipids and sea cucumber saponin on orotic acid-induced non-alcoholic fatty liver disease in rats. | 2018 | Details |
| A13209 | 30083132 | Front Endocrinol (Lausanne) | Interventional Potential of Recombinant Feline Hepatocyte Growth Factor in a Mouse Model of Non-alcoholic Steatohepatitis. | 2018 | Details |
| A13210 | 30081580 | Nutrients | Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways. | 2018 | Details |
| A13230 | 30073766 | Diabetes Obes Metab | Liraglutide treatment improves postprandial lipid metabolism and cardiometabolic risk factors in humans with adequately controlled type 2 diabetes: A single-centre randomized controlled study. | 2018 | Details |
| A13256 | 30061575 | Nat Commun | Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. | 2018 | Details |
| A13258 | 30060808 | Adv Cancer Res | Sphingolipids at the Crossroads of NAFLD and Senescence. | 2018 | Details |
| A13262 | 30060507 | Nutrients | Luteolin-Enriched Artichoke Leaf Extract Alleviates the Metabolic Syndrome in Mice with High-Fat Diet-Induced Obesity. | 2018 | Details |
| A13268 | 30059671 | Gastroenterology | GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A13280 | 30052880 | Endocrinology | GLP-2 Dysregulates Hepatic Lipoprotein Metabolism, Inducing Fatty Liver and VLDL Overproduction in Male Hamsters and Mice. | 2018 | Details |
| A13288 | 30049586 | Bioorg Med Chem | Design, synthesis and biological evaluation of novel spiro-pentacylamides as acetyl-CoA carboxylase inhibitors. | 2018 | Details |
| A13306 | 30038584 | Front Physiol | Stanniocalcin 2 Ameliorates Hepatosteatosis Through Activation of STAT3 Signaling. | 2018 | Details |
| A13334 | 30026731 | Front Endocrinol (Lausanne) | Comparative Study of Different Diets-Induced NAFLD Models of Zebrafish. | 2018 | Details |
| A13336 | 30026586 | Sci Rep | Substitution of linoleic acid with α-linolenic acid or long chain n-3 polyunsaturated fatty acid prevents Western diet induced nonalcoholic steatohepatitis. | 2018 | Details |
| A13372 | 30013137 | Nat Commun | Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis. | 2018 | Details |
| A13374 | 30012333 | Gastroenterology | Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases. | 2018 | Details |
| A13386 | 30006193 | Biochem Pharmacol | Pharmacological intervention of liver triacylglycerol lipolysis: The good, the bad and the ugly. | 2018 | Details |
| A13387 | 30006154 | Biochim Biophys Acta Mol Basis Dis | GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice. | 2018 | Details |
| A13388 | 30006135 | Arch Biochem Biophys | Ablation of carotenoid cleavage enzymes (BCO1 and BCO2) induced hepatic steatosis by altering the farnesoid X receptor/miR-34a/sirtuin 1 pathway. | 2018 | Details |
| A13408 | 29992215 | Lab Chip | Microphysiological flux balance platform unravels the dynamics of drug induced steatosis. | 2018 | Details |
| A13431 | 29976400 | J Food Drug Anal | Tetrahydrocurcumin ameliorates free fatty acid-induced hepatic steatosis and improves insulin resistance in HepG2 cells. | 2018 | Details |
| A13462 | 29960159 | Nutrition | Caffeic acid ameliorates hepatic steatosis and reduces ER stress in high fat diet-induced obese mice by regulating autophagy. | 2018 | Details |
| A13466 | 29958960 | J Ethnopharmacol | The polyherbal drug GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica inhibits hepatic steatosis and fibroinflammtion in high-fat diet-induced obese mice. | 2018 | Details |
| A13515 | 29936596 | Cell Mol Life Sci | Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease. | 2018 | Details |
| A13536 | 29925420 | Genome Biol | Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption. | 2018 | Details |
| A13553 | 29913436 | Cell Physiol Biochem | NEFA-Sensitive Orai1 Expression in Regulation of De Novo Lipogenesis. | 2018 | Details |
| A13580 | 29897151 | Chembiochem | Quinoline-Glycomimetic Conjugates Reducing Lipogenesis and Lipid Accumulation in Hepatocytes. | 2018 | Details |
| A13609 | 29880728 | Nutrients | Hepatoprotective Effects of Insect Extracts in an Animal Model of Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A13635 | 29860222 | Biomed Pharmacother | Acylated ghrelin induces but deacylated ghrelin prevents hepatic steatosis and insulin resistance in lean rats: Effects on DAG/ PKC/JNK pathway. | 2018 | Details |
| A13659 | 29852170 | Biochem Biophys Res Commun | Suppression of NF-κB activation by PDLIM2 restrains hepatic lipogenesis and inflammation in high fat diet induced mice. | 2018 | Details |
| A13668 | 29847555 | PLoS One | Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH. | 2018 | Details |
| A13679 | 29844096 | Diabetes Care | Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars. | 2018 | Details |
| A13701 | 29802129 | Diabetes | Production of Elastin-Derived Peptides Contributes to the Development of Nonalcoholic Steatohepatitis. | 2018 | Details |
| A13704 | 29800612 | Eur J Pharm Sci | Novel therapeutic drug identification and gene correlation for fatty liver disease using high-content screening: Proof of concept. | 2018 | Details |
| A13714 | 29795358 | Acta Pharmacol Sin | Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice. | 2018 | Details |
| A13724 | 29790582 | Hepatology | Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents. | 2018 | Details |
| A13730 | 29786745 | Int J Mol Med | Histone modifications in fatty acid synthase modulated by carbohydrate responsive element binding protein are associated with non‑alcoholic fatty liver disease. | 2018 | Details |
| A13740 | 29781841 | Curr Opin Clin Nutr Metab Care | Carbohydrates and diet patterns in nonalcoholic fatty liver disease in children and adolescents. | 2018 | Details |
| A13805 | 29747118 | J Nutr Biochem | Hydroxytyrosol ameliorates insulin resistance by modulating endoplasmic reticulum stress and prevents hepatic steatosis in diet-induced obesity mice. | 2018 | Details |
| A13813 | 29743930 | Nutr Metab (Lond) | LXRɑ participates in the mTOR/S6K1/SREBP-1c signaling pathway during sodium palmitate-induced lipogenesis in HepG2 cells. | 2018 | Details |
| A13814 | 29743929 | Nutr Metab (Lond) | Neonatal overfeeding induced glucocorticoid overexposure accelerates hepatic lipogenesis in male rats. | 2018 | Details |
| A13867 | 29719598 | Oncotarget | Hyperandrogenism and insulin resistance contribute to hepatic steatosis and inflammation in female rat liver. | 2018 | Details |
| A13872 | 29717275 | Int J Obes (Lond) | Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers. | 2018 | Details |
| A13883 | 29710765 | Nutrients | A Vitamin E-Enriched Antioxidant Diet Interferes with the Acute Adaptation of the Liver to Physical Exercise in Mice. | 2018 | Details |
| A13885 | 29710028 | J Nutr Sci Vitaminol (Tokyo) | Vitamin D Deficiency Increases Lipogenesis and Reduces Beta-Oxidation in the Liver of Diet-Induced Obese Mice. | 2018 | Details |
| A13891 | 29705265 | Clin Gastroenterol Hepatol | Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis. | 2018 | Details |
| A13894 | 29705134 | Biochimie | Increase in liver cytosolic lipases activities and VLDL-TAG secretion rate do not prevent the non-alcoholic fatty liver disease in cafeteria diet-fed rats. | 2018 | Details |
| A13901 | 29702089 | Chem Biol Interact | Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase. | 2018 | Details |
| A13910 | 29697539 | Curr Opin Clin Nutr Metab Care | Dietary carbohydrates and fatty liver disease: de novo lipogenesis. | 2018 | Details |
| A13914 | 29696816 | J Dig Dis | Deletion of Smad4 reduces hepatic inflammation and fibrogenesis during nonalcoholic steatohepatitis progression. | 2018 | Details |
| A13929 | 29684027 | PLoS One | Chronic calcitriol supplementation improves the inflammatory profiles of circulating monocytes and the associated intestinal/adipose tissue alteration in a diet-induced steatohepatitis rat model. | 2018 | Details |
| A13943 | 29678641 | Biochim Biophys Acta Mol Cell Biol Lipids | Liver-directed microRNA-7a depletion induces nonalcoholic fatty liver disease by stabilizing YY1-mediated lipogenic pathways in zebrafish. | 2018 | Details |
| A13951 | 29673898 | EBioMedicine | Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models. | 2018 | Details |
| A13991 | 29654899 | Toxicol In Vitro | "Trans-nonachlor increases extracellular free fatty acid accumulation and de novo lipogenesis to produce hepatic steatosis in McArdle-RH7777 cells". | 2018 | Details |
| A14008 | 29637446 | J Physiol Biochem | Effect of high chronic intake of sucrose on liver metabolism in aging rats. Modulation by rutin and micronutrients. | 2018 | Details |
| A14011 | 29635284 | Endocrinology | Divergent Role of Estrogen-Related Receptor α in Lipid- and Fasting-Induced Hepatic Steatosis in Mice. | 2018 | Details |
| A14020 | 29631603 | Lipids Health Dis | Heat shock protein 70 promotes lipogenesis in HepG2 cells. | 2018 | Details |
| A14027 | 29629027 | Nutr Res Pract | Ethanol extract of Allium fistulosum inhibits development of non-alcoholic fatty liver disease. | 2018 | Details |
| A14042 | 29620148 | Int J Mol Med | Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS. | 2018 | Details |
| A14063 | 29604329 | Mol Cell Endocrinol | MiR-451a attenuates free fatty acids-mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene. | 2018 | Details |
| A14082 | 29599631 | Malays J Med Sci | The Effect of Amygdalin on Endoplasmic Reticulum (ER) Stress Induced Hepatic Steatosis in Mice. | 2018 | Details |
| A14091 | 29593573 | Front Physiol | Rho, a Fraction From Rhodiola crenulate, Ameliorates Hepatic Steatosis in Mice Models. | 2018 | Details |
| A14105 | 29580823 | Mol Cell Endocrinol | GW0742 (PPAR-beta agonist) attenuates hepatic endoplasmic reticulum stress by improving hepatic energy metabolism in high-fat diet fed mice. | 2018 | Details |
| A14115 | 29575149 | J Cell Biochem | Exercise decreases CLK2 in the liver of obese mice and prevents hepatic fat accumulation. | 2018 | Details |
| A14140 | 29567249 | J Food Drug Anal | Mulberry Leaf Extracts prevent obesity-induced NAFLD with regulating adipocytokines, inflammation and oxidative stress. | 2017 | Details |
| A14169 | 29555473 | Biochem Biophys Res Commun | Long noncoding RNA lncARSR promotes hepatic lipogenesis via Akt/SREBP-1c pathway and contributes to the pathogenesis of nonalcoholic steatohepatitis. | 2018 | Details |
| A14172 | 29552625 | Cell Mol Gastroenterol Hepatol | Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2). | 2017 | Details |
| A14207 | 29526751 | Biochem Biophys Res Commun | Enoyl coenzyme A hydratase 1 protects against high-fat-diet-induced hepatic steatosis and insulin resistance. | 2018 | Details |
| A14248 | 29507043 | J Endocrinol | Lactobacillus acidophilus NS1 attenuates diet-induced obesity and fatty liver. | 2018 | Details |
| A14278 | 29486327 | Biochim Biophys Acta Mol Cell Biol Lipids | FTO promotes SREBP1c maturation and enhances CIDEC transcription during lipid accumulation in HepG2 cells. | 2018 | Details |
| A14289 | 29481986 | J Nutr Biochem | Replacement of soybean oil by fish oil increases cytosolic lipases activities in liver and adipose tissue from rats fed a high-carbohydrate diets. | 2018 | Details |
| A14291 | 29480487 | Methods Mol Biol | Measurement of AMPK-Induced Inhibition of Lipid Synthesis Flux in Cultured Cells. | 2018 | Details |
| A14303 | 29472712 | Nat Rev Endocrinol | Direct effects of thyroid hormones on hepatic lipid metabolism. | 2018 | Details |
| A14319 | 29469041 | Ann Hepatol | Natural Extracts Abolished Lipid Accumulation in Cells Harbouring non-favourable PNPLA3 genotype. | 2018 | Details |
| A14335 | 29462565 | Am J Physiol Endocrinol Metab | Pycnogenol protects against diet-induced hepatic steatosis in apolipoprotein-E-deficient mice. | 2018 | Details |
| A14343 | 29456073 | Cell Metab | An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans. | 2018 | Details |
| A14344 | 29454969 | Biochem Biophys Res Commun | JIP3 knockout protects mice against high fat diet-induced liver injury. | 2018 | Details |
| A14345 | 29454967 | Biochem Biophys Res Commun | SARM1 deletion restrains NAFLD induced by high fat diet (HFD) through reducing inflammation, oxidative stress and lipid accumulation. | 2018 | Details |