Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A14210 | 29525610 | Nutr Res | Arctigenin protects against steatosis in WRL68 hepatocytes through activation of phosphoinositide 3-kinase/protein kinase B and AMP-activated protein kinase pathways. | 2018 | Details |
| A14216 | 29522534 | PLoS One | Niemann-Pick type C2 protein supplementation in experimental non-alcoholic fatty liver disease. | 2018 | Details |
| A14225 | 29516226 | Eur J Nutr | Chronic fructose intake does not induce liver steatosis and inflammation in female Sprague-Dawley rats, but causes hypertriglyceridemia related to decreased VLDL receptor expression. | 2018 | Details |
| A14229 | 29514661 | J Transl Med | Physiological and molecular effects of interleukin-18 administration on the mouse kidney. | 2018 | Details |
| A14242 | 29508519 | Mol Nutr Food Res | Caffeic Acid Phenethyl Ester Improves Metabolic Syndrome by Activating PPAR-γ and Inducing Adipose Tissue Remodeling in Diet-Induced Obese Mice. | 2018 | Details |
| A14248 | 29507043 | J Endocrinol | Lactobacillus acidophilus NS1 attenuates diet-induced obesity and fatty liver. | 2018 | Details |
| A14265 | 29494209 | Am J Physiol Gastrointest Liver Physiol | Biliverdin reductase and bilirubin in hepatic disease. | 2018 | Details |
| A14270 | 29491146 | J Biol Chem | Mice lacking ARV1 have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease. | 2018 | Details |
| A14319 | 29469041 | Ann Hepatol | Natural Extracts Abolished Lipid Accumulation in Cells Harbouring non-favourable PNPLA3 genotype. | 2018 | Details |
| A14325 | 29464180 | Int J Genomics | Lingguizhugan Decoction Protects against High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress and Activating Cholesterol Secretion. | 2017 | Details |
| A14341 | 29456675 | Exp Ther Med | Correlation between PPAR-α methylation level in peripheral blood and atherosclerosis of NAFLD patients with DM. | 2018 | Details |
| A14343 | 29456073 | Cell Metab | An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans. | 2018 | Details |
| A14344 | 29454969 | Biochem Biophys Res Commun | JIP3 knockout protects mice against high fat diet-induced liver injury. | 2018 | Details |
| A14362 | 29446942 | J Med Chem | Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate. | 2018 | Details |
| A14366 | 29445363 | Front Microbiol | Helicobacter pylori Infection Is Not Associated with Non-alcoholic Fatty Liver Disease: A Cross-Sectional Study in China. | 2018 | Details |
| A14380 | 29437160 | Int J Obes (Lond) | Protective effect of black relative to white race against non-alcoholic fatty liver disease in patients with severe obesity, independent of type 2 diabetes. | 2017 | Details |
| A14382 | 29434731 | Exp Ther Med | Correlation between PPAR-α methylation level in peripheral blood and inflammatory factors of NAFLD patients with DM. | 2017 | Details |
| A14393 | 29429367 | Arch Physiol Biochem | Obestatin protects and reverses nonalcoholic fatty liver disease and its associated insulin resistance in rats via inhibition of food intake, enhancing hepatic adiponectin signaling, and blocking ghrelin acylation. | 2018 | Details |
| A14395 | 29428667 | Biomed Pharmacother | Silybum marianum oil attenuates hepatic steatosis and oxidative stress in high fat diet-fed mice. | 2018 | Details |
| A14409 | 29421523 | Transl Res | Maraviroc improves hepatic triglyceride content but not inflammation in a murine nonalcoholic fatty liver disease model induced by a chronic exposure to high-fat diet. | 2018 | Details |
| A14461 | 29400110 | Free Radic Res | Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway. | 2018 | Details |
| A14462 | 29399555 | Adv Pharm Bull | Effect of Daily Caper Fruit Pickle Consumption on Disease Regression in Patients with Non-Alcoholic Fatty Liver Disease: a Double-Blinded Randomized Clinical Trial. | 2017 | Details |
| A14469 | 29398867 | World J Gastroenterol | Diet switch and omega-3 hydroxy-fatty acids display differential hepatoprotective effects in an obesity/nonalcoholic fatty liver disease model in mice. | 2018 | Details |
| A14478 | 29391755 | World J Gastroenterol | circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling. | 2018 | Details |
| A14518 | 29371998 | Toxicol Res | Protective Effect of Isoliquiritigenin against Ethanol-Induced Hepatic Steatosis by Regulating the SIRT1-AMPK Pathway. | 2018 | Details |
| A14519 | 29371918 | Oncotarget | Long-term administration of tacrolimus and everolimus prevents high cholesterol-high fructose-induced steatosis in C57BL/6J mice by inhibiting de-novo lipogenesis. | 2017 | Details |
| A14534 | 29364302 | Food Funct | Effects of a combined intervention with a lentil protein hydrolysate and a mixed training protocol on the lipid metabolism and hepatic markers of NAFLD in Zucker rats. | 2018 | Details |
| A14541 | 29361497 | Mol Metab | Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR. | 2018 | Details |
| A14543 | 29360762 | Mar Drugs | Protective Effect of Meretrix meretrix Oligopeptides on High-Fat-Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. | 2018 | Details |
| A14550 | 29358945 | PPAR Res | Peroxisome Proliferator-Activated Receptors Associated with Nonalcoholic Fatty Liver Disease. | 2017 | Details |
| A14564 | 29351486 | Am J Physiol Endocrinol Metab | Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. | 2017 | Details |
| A14568 | 29350678 | Exp Mol Med | PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis. | 2018 | Details |
| A14600 | 29330220 | Drug Metab Dispos | Regulation of Drug Metabolism by the Interplay of Inflammatory Signaling, Steatosis, and Xeno-Sensing Receptors in HepaRG Cells. | 2018 | Details |
| A14642 | 29311481 | Biol Pharm Bull | A PPAR Pan Agonist, MHY2013 Alleviates Age-Related Hepatic Lipid Accumulation by Promoting Fatty Acid Oxidation and Suppressing Inflammation. | 2018 | Details |
| A14649 | 29309075 | Food Funct | Niga-ichigoside F1 ameliorates high-fat diet-induced hepatic steatosis in male mice by Nrf2 activation. | 2018 | Details |
| A14669 | 29295591 | Nutrients | Leonurus japonicus Houtt Attenuates Nonalcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Cells and Mice Fed a High-Fat Diet. | 2017 | Details |
| A14680 | 29289645 | Mol Metab | Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease. | 2017 | Details |
| A14696 | 29286302 | Int J Mol Sci | MicroRNA-27b Depletion Enhances Endotrophic and Intravascular Lipid Accumulation and Induces Adipocyte Hyperplasia in Zebrafish. | 2017 | Details |
| A14705 | 29280057 | Obes Surg | Effects of Sleeve Gastrectomy on Nonalcoholic Fatty Liver Disease in an Obese Rat Model. | 2018 | Details |
| A14708 | 29278765 | Magn Reson Imaging | Gd-EOB-DTPA-enhanced T1ρ imaging vs diffusion metrics for assessment liver inflammation and early stage fibrosis of nonalcoholic steatohepatitis in rabbits. | 2017 | Details |
| A14718 | 29273476 | J Hepatol | Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice. | 2017 | Details |
| A14764 | 29249184 | Hum Exp Toxicol | Caffeine affects HFD-induced hepatic steatosis by multifactorial intervention. | 2017 | Details |
| A14815 | 29222421 | Sci Rep | The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease. | 2017 | Details |
| A14818 | 29221790 | Metabolism | FAM3 gene family: A promising therapeutical target for NAFLD and type 2 diabetes. | 2017 | Details |
| A14842 | 29209111 | World J Gastroenterol | Palmitate induces fat accumulation by activating C/EBPβ-mediated G0S2 expression in HepG2 cells. | 2017 | Details |
| A14861 | 29201200 | Exp Ther Med | Effect of a stilbene glycoside-rich extract from Polygoni Multiflori Radix on experimental non-alcoholic fatty liver disease based on principal component and orthogonal partial least squares discriminant analysis. | 2017 | Details |
| A14864 | 29201040 | PPAR Res | Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice. | 2017 | Details |
| A14871 | 29197627 | Int J Biochem Cell Biol | MiR-34a regulates mitochondrial content and fat ectopic deposition induced by resistin through the AMPK/PPARα pathway in HepG2 cells. | 2017 | Details |
| A14873 | 29197406 | Lipids Health Dis | Non-HDL cholesterol and LDL cholesterol in the dyslipidemic classification in patients with nonalcoholic fatty liver disease. | 2017 | Details |
| A14885 | 29191128 | Biosci Biotechnol Biochem | Suppressive effect of nobiletin and epicatechin gallate on fructose uptake in human intestinal epithelial Caco-2 cells. | 2017 | Details |
| A14906 | 29179698 | BMC Gastroenterol | Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice. | 2017 | Details |
| A14920 | 29174039 | Biomed Pharmacother | Lavatera critica, a green leafy vegetable, controls high fat diet induced hepatic lipid accumulation and oxidative stress through the regulation of lipogenesis and lipolysis genes. | 2017 | Details |
| A14931 | 29167659 | Front Microbiol | Balancing Herbal Medicine and Functional Food for Prevention and Treatment of Cardiometabolic Diseases through Modulating Gut Microbiota. | 2017 | Details |
| A14933 | 29167318 | Clin Sci (Lond) | TRAIL reduces impaired glucose tolerance and NAFLD in the high-fat diet fed mouse. | 2018 | Details |
| A14940 | 29164820 | Liver Int | Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models. | 2017 | Details |
| A14952 | 29158770 | Nutr Metab (Lond) | Does the enterolactone (ENL) affect fatty acid transporters and lipid metabolism in liver? | 2017 | Details |
| A14956 | 29158052 | Life Sci | Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice. | 2017 | Details |
| A14957 | 29156529 | Biomed Pharmacother | Alpinetin improved high fat diet-induced non-alcoholic fatty liver disease (NAFLD) through improving oxidative stress, inflammatory response and lipid metabolism. | 2017 | Details |
| A15000 | 29129237 | Nutrition | Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues. | 2017 | Details |
| A15064 | 29113135 | Nutrients | Nonalcoholic Fatty Liver Disease Is Exacerbated in High-Fat Diet-Fed Gnotobiotic Mice by Colonization with the Gut Microbiota from Patients with Nonalcoholic Steatohepatitis. | 2017 | Details |
| A15103 | 29093267 | JCI Insight | Loss of miR-141/200c ameliorates hepatic steatosis and inflammation by reprogramming multiple signaling pathways in NASH. | 2017 | Details |
| A15104 | 29092796 | Mol Metab | AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice. | 2017 | Details |
| A15110 | 29089934 | Front Microbiol | Prebiotic and Synbiotic Modifications of Beta Oxidation and Lipogenic Gene Expression after Experimental Hypercholesterolemia in Rat Liver. | 2017 | Details |
| A15133 | 29081885 | Oxid Med Cell Longev | Dietary Flaxseed Oil Prevents Western-Type Diet-Induced Nonalcoholic Fatty Liver Disease in Apolipoprotein-E Knockout Mice. | 2017 | Details |
| A15140 | 29077272 | J Cell Mol Med | Inhibition of MD2-dependent inflammation attenuates the progression of non-alcoholic fatty liver disease. | 2017 | Details |
| A15215 | 29042644 | Sci Rep | HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD. | 2017 | Details |
| A15232 | 29031784 | J Ethnopharmacol | Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics for the investigation of the effect of Hugan Qingzhi on non-alcoholic fatty liver disease in rats. | 2017 | Details |
| A15233 | 29031724 | Mol Metab | Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease. | 2017 | Details |
| A15241 | 29027424 | Zhongguo Zhong Yao Za Zhi | [Research progress on therapeutic targets of active components in Chinese herbs for treatment of nonalcoholic fatty liver disease]. | 2017 | Details |
| A15260 | 29018509 | Oxid Med Cell Longev | circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis. | 2017 | Details |
| A15293 | 28982243 | J Agric Food Chem | Solanum nigrum Polyphenol Extracts Inhibit Hepatic Inflammation, Oxidative Stress, and Lipogenesis in High-Fat-Diet-Treated Mice. | 2017 | Details |
| A15297 | 28980219 | Curr Environ Health Rep | Persistent Endocrine-Disrupting Chemicals and Fatty Liver Disease. | 2017 | Details |
| A15328 | 28965030 | J Nutr Biochem | Baked corn (Zea mays L.) and bean (Phaseolus vulgaris L.) snack consumption lowered serum lipids and differentiated liver gene expression in C57BL/6 mice fed a high-fat diet by inhibiting PPARγ and SREBF2. | 2017 | Details |
| A15344 | 28955124 | J Clin Biochem Nutr | Effects of soy isoflavone on hepatic steatosis in high fat-induced rats. | 2017 | Details |
| A15361 | 28946547 | Cancer Biomark | Pioglitazone suppresses inflammation and fibrosis in nonalcoholic fatty liver disease by down-regulating PDGF and TIMP-2: Evidence from in vitro study. | 2017 | Details |
| A15374 | 28940752 | Mol Nutr Food Res | Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High-Fat Diet in Mice through PPAR-α and Nrf2 Upregulation with Concomitant SREBP-1c and NF-kB Downregulation. | 2017 | Details |
| A15376 | 28939830 | Sci Rep | Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD. | 2017 | Details |
| A15417 | 28923496 | Gastroenterology | Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice. | 2017 | Details |
| A15500 | 28874443 | J Lipid Res | Amelioration of diet-induced steatohepatitis in mice following combined therapy with ASO-Fsp27 and fenofibrate. | 2017 | Details |
| A15501 | 28874313 | Gastroenterol Hepatol | New therapeutic perspectives in non-alcoholic steatohepatitis. | 2017 | Details |
| A15513 | 28867301 | Cell Metab | Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases. | 2017 | Details |
| A15514 | 28867186 | Biochem Biophys Res Commun | Dietary β-conglycinin prevents acute ethanol-induced fatty liver in mice. | 2017 | Details |
| A15582 | 28831172 | Sci Rep | Pioglitazone Enhances Cytosolic Lipolysis, β-oxidation and Autophagy to Ameliorate Hepatic Steatosis. | 2017 | Details |
| A15599 | 28821440 | Cell Signal | Apelin protects against liver X receptor-mediated steatosis through AMPK and PPARα in human and mouse hepatocytes. | 2017 | Details |
| A15615 | 28809727 | Ann Hepatol | Models of non-Alcoholic Fatty Liver Disease and Potential Translational Value: the Effects of 3,5-L-diiodothyronine. | 2018 | Details |
| A15625 | 28802640 | Clin Chim Acta | Nonalcoholic fatty liver disease associated with metabolic syndrome: Influence of liver fibrosis stages on characteristics of very low-density lipoproteins. | 2017 | Details |
| A15673 | 28774777 | Mol Cell Endocrinol | Insights into the role of hepatocyte PPARα activity in response to fasting. | 2017 | Details |
| A15677 | 28770225 | Biomed Res Int | PEGylated Curcumin Derivative Attenuates Hepatic Steatosis via CREB/PPAR-γ/CD36 Pathway. | 2017 | Details |
| A15781 | 28711683 | Biochimie | Anti-obesogenic effects of WY14643 (PPAR-alpha agonist): Hepatic mitochondrial enhancement and suppressed lipogenic pathway in diet-induced obese mice. | 2017 | Details |
| A15829 | 28691342 | Mol Nutr Food Res | Dual function of Lactobacillus kefiri DH5 in preventing high-fat-diet-induced obesity: direct reduction of cholesterol and upregulation of PPAR-α in adipose tissue. | 2017 | Details |
| A15886 | 28670854 | J Gastroenterol Hepatol | Honokiol attenuates diet-induced non-alcoholic steatohepatitis by regulating macrophage polarization through activating peroxisome proliferator-activated receptor γ. | 2018 | Details |
| A15888 | 28670394 | Am J Transl Res | PFP alleviates nonalcoholic steatohepatitis fatty liver in both Apo E-/- mice and Changliver cell[S]. | 2017 | Details |
| A15892 | 28667519 | Sci China Life Sci | Retinoic acid ameliorates high-fat diet-induced liver steatosis through sirt1. | 2017 | Details |
| A15925 | 28648927 | J Ethnopharmacol | Silibinin Capsules improves high fat diet-induced nonalcoholic fatty liver disease in hamsters through modifying hepatic de novo lipogenesis and fatty acid oxidation. | 2017 | Details |
| A15934 | 28645738 | J Hepatol | Human germline hedgehog pathway mutations predispose to fatty liver. | 2017 | Details |
| A15937 | 28643888 | Mol Nutr Food Res | Combination of citrus polymethoxyflavones, green tea polyphenols, and Lychee extracts suppresses obesity and hepatic steatosis in high-fat diet induced obese mice. | 2017 | Details |
| A15959 | 28637104 | Korean J Gastroenterol | [Treatment Options in Non-alcoholic Fatty Liver Disease]. | 2017 | Details |
| A15978 | 28628909 | J Nutr Biochem | Nonalcoholic fatty liver disease impairs the cytochrome P-450-dependent metabolism of α-tocopherol (vitamin E). | 2017 | Details |
| A16049 | 28594915 | PLoS One | Conophylline inhibits non-alcoholic steatohepatitis in mice. | 2017 | Details |
| A16050 | 28593786 | Rev Esp Enferm Dig | Characterization of liver changes in ZSF1 rats, an animal model of metabolic syndrome. | 2017 | Details |