Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Peroxisome proliferator-activated receptor gamma207 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00219 | 35178989 | Zhongguo Zhong Yao Za Zhi | [Mechanism of Zexie Decoction in improvement of nonalcoholic fatty liver disease based on LKB1/AMPK/PGC-1α pathway]. | 2022 | Details |
| A00383 | 35108454 | FEBS Open Bio | Carbonic anhydrase 3 increases during liver adipogenesis even in pre-obesity, and its inhibitors reduce liver adipose accumulation. | 2022 | Details |
| A00390 | 35104757 | Phytomedicine | Seed oil of Rosa roxburghii Tratt against non-alcoholic fatty liver disease in vivo and in vitro through PPARα/PGC-1α-mediated mitochondrial oxidative metabolism. | 2022 | Details |
| A00579 | 35041255 | Phytother Res | Activation of PGC-1α via isoliquiritigenin-induced downregulation of miR-138-5p alleviates nonalcoholic fatty liver disease. | 2022 | Details |
| A00808 | 34959747 | Nutrients | High-Fructose, High-Fat Diet Alters Muscle Composition and Fuel Utilization in a Juvenile Iberian Pig Model of Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A01000 | 34906049 | Biochemistry (Mosc) | AMPK/PGC-1α/GLUT4-Mediated Effect of Icariin on Hyperlipidemia-Induced Non-Alcoholic Fatty Liver Disease and Lipid Metabolism Disorder in Mice. | 2021 | Details |
| A01029 | 34897744 | J Appl Toxicol | Fluoxetine-induced hepatic lipid accumulation is mediated by prostaglandin endoperoxide synthase 1 and is linked to elevated 15-deoxy-Δ12,14 PGJ2. | 2021 | Details |
| A01082 | 34874519 | Chin J Integr Med | Lycium barbarum Polysaccharides Promotes Mitochondrial Biogenesis and Energy Balance in a NAFLD Cell Model. | 2021 | Details |
| A01811 | 34606980 | Endocr Pract | Antidiabetic Medications for Type 2 Diabetics with Nonalcoholic Fatty Liver Disease: Evidence From a Network Meta-Analysis of Randomized Controlled Trials. | 2021 | Details |
| A01884 | 34573421 | Genes (Basel) | The Mitochondrial Trigger in an Animal Model of Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A02434 | 34372491 | Viruses | Findings from Studies Are Congruent with Obesity Having a Viral Origin, but What about Obesity-Related NAFLD? | 2021 | Details |
| A02523 | 34341928 | Environ Sci Pollut Res Int | Metronidazole enhances steatosis-related early-stage hepatocarcinogenesis in high fat diet-fed rats through DNA double-strand breaks and modulation of autophagy. | 2021 | Details |
| A02528 | 34340181 | Environ Pollut | An adverse outcome pathway based in vitro characterization of novel flame retardants-induced hepatic steatosis. | 2021 | Details |
| A02587 | 34321850 | World J Gastroenterol | PPARGC1A rs8192678 G>A polymorphism affects the severity of hepatic histological features and nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease. | 2021 | Details |
| A03245 | 34073834 | Int J Mol Sci | P2Y2R Deficiency Ameliorates Hepatic Steatosis by Reducing Lipogenesis and Enhancing Fatty Acid β-Oxidation through AMPK and PGC-1α Induction in High-Fat Diet-Fed Mice. | 2021 | Details |
| A03247 | 34072832 | Cells | Epigenetic Regulation of Peroxisome Proliferator-Activated Receptor Gamma Mediates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A03255 | 34069390 | Cells | Maternal Exercise Mediates Hepatic Metabolic Programming via Activation of AMPK-PGC1α Axis in the Offspring of Obese Mothers. | 2021 | Details |
| A03289 | 34059612 | Curr Opin Cardiol | Update on cardiovascular risk in nonalcoholic fatty liver disease. | 2021 | Details |
| A03632 | 33924115 | Int J Mol Sci | Chronic High Fat Diet Intake Impairs Hepatic Metabolic Parameters in Ovariectomized Sirt3 KO Mice. | 2021 | Details |
| A03684 | 33902605 | Lipids Health Dis | Elucidation of SIRT-1/PGC-1α-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease. | 2021 | Details |
| A03834 | 33853848 | BMJ Open Diabetes Res Care | Interleukin-6 mediated exercise-induced alleviation of adiposity and hepatic steatosis in mice. | 2021 | Details |
| A04933 | 33444819 | Cell Mol Gastroenterol Hepatol | Hepatocyte-Specific Loss of PPARγ Protects Mice From NASH and Increases the Therapeutic Effects of Rosiglitazone in the Liver. | 2021 | Details |
| A05207 | 33339155 | Antioxidants (Basel) | N-Acetyl Cysteine Targets Hepatic Lipid Accumulation to Curb Oxidative Stress and Inflammation in NAFLD: A Comprehensive Analysis of the Literature. | 2020 | Details |
| A05326 | 33302316 | Horm Metab Res | Acute Elevated Resistin Exacerbates Mitochondrial Damage and Aggravates Liver Steatosis Through AMPK/PGC-1α Signaling Pathway in Male NAFLD Mice. | 2020 | Details |
| A06289 | 32940033 | J Agric Food Chem | (-)-Hydroxycitric Acid Alleviates Oleic Acid-Induced Steatosis, Oxidative Stress, and Inflammation in Primary Chicken Hepatocytes by Regulating AMP-Activated Protein Kinase-Mediated Reactive Oxygen Species Levels. | 2020 | Details |
| A06295 | 32937687 | Clin Mol Hepatol | Obesity and binge alcohol intake are deadly combination to induce steatohepatitis: A model of high-fat diet and binge ethanol intake. | 2020 | Details |
| A06318 | 32931733 | Cell | Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output. | 2020 | Details |
| A06669 | 32786868 | J Agric Food Chem | Fermented Soy Paste Alleviates Lipid Accumulation in the Liver by Regulating the AMPK Pathway and Modulating Gut Microbiota in High-Fat-Diet-Fed Rats. | 2020 | Details |
| A06751 | 32759940 | Nutr Diabetes | Neohesperidin enhances PGC-1α-mediated mitochondrial biogenesis and alleviates hepatic steatosis in high fat diet fed mice. | 2020 | Details |
| A07306 | 32546444 | Dig Liver Dis | Increased risk of acute liver failure by pain killer drugs in NAFLD: Focus on nuclear receptors and their coactivators. | 2020 | Details |
| A07425 | 32505733 | Clin Res Hepatol Gastroenterol | PPARγ gene Pro12Ala variants reduce the risk of obese individuals to non-alcoholic fatty liver: A study in Uygur Chinese population residing in Northwestern China. | 2020 | Details |
| A07577 | 32437795 | Life Sci | TLR4 knockout upregulates the expression of Mfn2 and PGC-1α in a high-fat diet and ischemia-reperfusion mice model of liver injury. | 2020 | Details |
| A07641 | 32411189 | PPAR Res | Loss of Hepatocyte-Specific PPARγ Expression Ameliorates Early Events of Steatohepatitis in Mice Fed the Methionine and Choline-Deficient Diet. | 2020 | Details |
| A07809 | 32349939 | Ann Hepatol | Epidemiology and pathophysiology of the association between NAFLD and metabolically healthy or metabolically unhealthy obesity. | 2020 | Details |
| A07958 | 32299444 | Lipids Health Dis | MiR-30b-5p regulates the lipid metabolism by targeting PPARGC1A in Huh-7 cell line. | 2020 | Details |
| A07965 | 32297157 | Virol Sin | Effect of Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 Alpha Variants on Spontaneous Clearance and Fibrosis Progression during Hepatitis C Virus Infection in Moroccan Patients. | 2020 | Details |
| A08073 | 32258142 | Biomed Res Int | Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARδ-AMPK-PGC-1α Pathway in Dyslipidemic Conditions. | 2020 | Details |
| A08108 | 32244266 | Int J Mol Sci | Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk. | 2020 | Details |
| A08338 | 32148418 | J Ginseng Res | Ameliorative effects of black ginseng on nonalcoholic fatty liver disease in free fatty acid-induced HepG2 cells and high-fat/high-fructose diet-fed mice. | 2019 | Details |
| A08606 | 32043636 | FASEB J | REDD1 deficiency protects against nonalcoholic hepatic steatosis induced by high-fat diet. | 2020 | Details |
| A08860 | 31959914 | Cell Death Differ | Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. | 2020 | Details |
| A09059 | 33762794 | Toxicol Environ Chem | Perfluorobutanesulfonic Acid (PFBS) Induces Fat Accumulation in HepG2 Human Hepatoma. | 2020 | Details |
| A09182 | 31846369 | Am J Physiol Endocrinol Metab | Pgc1a is responsible for the sex differences in hepatic Cidec/Fsp27β mRNA expression in hepatic steatosis of mice fed a Western diet. | 2019 | Details |
| A09186 | 31843573 | J Ethnopharmacol | San-Huang-Tang protects obesity/diabetes induced NAFLD by upregulating PGC-1α/PEPCK signaling in obese and galr1 knockout mice models. | 2019 | Details |
| A09222 | 31832001 | World J Gastroenterol | LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway. | 2019 | Details |
| A09662 | 31654717 | Cell Signal | Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma. | 2019 | Details |
| A10099 | 31484323 | Nutrients | Indole-3-Acetic Acid Alleviates Nonalcoholic Fatty Liver Disease in Mice via Attenuation of Hepatic Lipogenesis, and Oxidative and Inflammatory Stress. | 2019 | Details |
| A10166 | 31462971 | Comput Struct Biotechnol J | Hallmarks of Aging in the Liver. | 2019 | Details |
| A10309 | 31390852 | Turk J Med Sci | Association between PPARGC1A single nucleotide polymorphisms and increased risk of nonalcoholic fatty liver disease among Iranian patients with type 2 diabetes mellitus | 2019 | Details |
| A10667 | 31245168 | Liver Res | Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2. | 2018 | Details |
| A10991 | 31089410 | Oxid Med Cell Longev | Higd1a Protects Cells from Lipotoxicity under High-Fat Exposure. | 2019 | Details |
| A11059 | 31063640 | Hepatology | Pharmacologic Inhibition of Epidermal Growth Factor Receptor Suppresses Nonalcoholic Fatty Liver Disease in a Murine Fast-Food Diet Model. | 2019 | Details |
| A11107 | 31039348 | Exp Cell Res | Epoxyeicosatrienoic intervention improves NAFLD in leptin receptor deficient mice by an increase in PGC1α-HO-1-PGC1α-mitochondrial signaling. | 2019 | Details |
| A11108 | 31039007 | Am J Physiol Endocrinol Metab | Sex modulates hepatic mitochondrial adaptations to high-fat diet and physical activity. | 2019 | Details |
| A11124 | 31032705 | Autophagy | Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels. | 2019 | Details |
| A11557 | 30841472 | Biomed Pharmacother | Biochemical and histological characterisation of an experimental rodent model of non-alcoholic steatohepatitis - Effects of a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist and a glucagon-like peptide-1 analogue. | 2019 | Details |
| A11625 | 30813654 | Nutrients | Lonicera caerulea Extract Attenuates Non-Alcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Hepatocytes and in High Fat Diet-Fed Mice. | 2019 | Details |
| A12137 | 30588181 | Int J Med Sci | Phenotypic Alteration of Hepatocytes in Non-Alcoholic Fatty Liver Disease. | 2018 | Details |
| A12157 | 30578708 | Mol Nutr Food Res | Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro. | 2019 | Details |
| A12577 | 30381838 | J Physiol | SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding. | 2018 | Details |
| A12588 | 30374329 | Front Endocrinol (Lausanne) | Therapeutic Approaches to Nonalcoholic Fatty Liver Disease: Exercise Intervention and Related Mechanisms. | 2018 | Details |
| A12615 | 30363699 | PPAR Res | Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression. | 2018 | Details |
| A12781 | 30291215 | Biosci Rep | The Chinese medicine Chai Hu Li Zhong Tang protects against non-alcoholic fatty liver disease by activating AMPKα. | 2018 | Details |
| A12786 | 30288476 | Hepatol Commun | Hepatic Nuclear Receptor Expression Associates with Features of Histology in Pediatric Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A12979 | 30198086 | J Sci Food Agric | Dietary salmon milt extracts attenuate hepatosteatosis and liver dysfunction in diet-induced fatty liver model. | 2018 | Details |
| A13113 | 30134762 | Int J Toxicol | Paradoxical Protective Effect of Perfluorooctanesulfonic Acid Against High-Fat Diet-Induced Hepatic Steatosis in Mice. | 2018 | Details |
| A13316 | 30036051 | J Agric Food Chem | Cichoric Acid Prevents Free-Fatty-Acid-Induced Lipid Metabolism Disorders via Regulating Bmal1 in HepG2 Cells. | 2018 | Details |
| A13387 | 30006154 | Biochim Biophys Acta Mol Basis Dis | GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice. | 2018 | Details |
| A13431 | 29976400 | J Food Drug Anal | Tetrahydrocurcumin ameliorates free fatty acid-induced hepatic steatosis and improves insulin resistance in HepG2 cells. | 2018 | Details |
| A13460 | 29962430 | J Nutr Sci Vitaminol (Tokyo) | L-Lysine Attenuates Hepatic Steatosis in Senescence-Accelerated Mouse Prone 8 Mice. | 2018 | Details |
| A13987 | 29656250 | Environ Pollut | Exposure to environmental level phenanthrene induces a NASH-like phenotype in new born rat. | 2018 | Details |
| A14072 | 29602237 | J Cell Mol Med | NEFA-induced ROS impaired insulin signalling through the JNK and p38MAPK pathways in non-alcoholic steatohepatitis. | 2018 | Details |
| A14177 | 29550470 | Biochem Biophys Res Commun | PPARγ alleviated hepatocyte steatosis through reducing SOCS3 by inhibiting JAK2/STAT3 pathway. | 2018 | Details |
| A14301 | 29474931 | Biochim Biophys Acta Mol Cell Biol Lipids | Alpha-syntrophin null mice are protected from non-alcoholic steatohepatitis in the methionine-choline-deficient diet model but not the atherogenic diet model. | 2018 | Details |
| A14361 | 29447962 | Int J Biol Macromol | Low molecular weight fucoidan attenuates liver injury via SIRT1/AMPK/PGC1α axis in db/db mice. | 2018 | Details |
| A14461 | 29400110 | Free Radic Res | Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway. | 2018 | Details |
| A14519 | 29371918 | Oncotarget | Long-term administration of tacrolimus and everolimus prevents high cholesterol-high fructose-induced steatosis in C57BL/6J mice by inhibiting de-novo lipogenesis. | 2017 | Details |
| A14906 | 29179698 | BMC Gastroenterol | Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice. | 2017 | Details |
| A14933 | 29167318 | Clin Sci (Lond) | TRAIL reduces impaired glucose tolerance and NAFLD in the high-fat diet fed mouse. | 2018 | Details |
| A15064 | 29113135 | Nutrients | Nonalcoholic Fatty Liver Disease Is Exacerbated in High-Fat Diet-Fed Gnotobiotic Mice by Colonization with the Gut Microbiota from Patients with Nonalcoholic Steatohepatitis. | 2017 | Details |
| A16108 | 28566408 | J Mol Endocrinol | 5-ALA ameliorates hepatic steatosis through AMPK signaling pathway. | 2017 | Details |
| A16161 | 28529818 | J Diabetes Metab | High protein/fish oil diet prevents hepatic steatosis in NONcNZO10 mice; association with diet/genetics-regulated micro-RNAs. | 2016 | Details |
| A16163 | 28529649 | Theranostics | SAK-HV Triggered a Short-period Lipid-lowering Biotherapy Based on the Energy Model of Liver Proliferation via a Novel Pathway. | 2017 | Details |
| A16406 | 28414138 | Biochem Pharmacol | Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation. | 2017 | Details |
| A16687 | 28244120 | Hepatology | The histone methyltransferase Suv39h2 contributes to nonalcoholic steatohepatitis in mice. | 2017 | Details |
| A16935 | 28084795 | Appl Physiol Nutr Metab | Moderate physical activity promotes basal hepatic autophagy in diet-induced obese mice. | 2016 | Details |
| A17125 | 27979751 | J Hepatol | PARP1-mediated PPARα poly(ADP-ribosyl)ation suppresses fatty acid oxidation in non-alcoholic fatty liver disease. | 2016 | Details |
| A17196 | 27917591 | Diabetes Obes Metab | The PDE4 inhibitor roflumilast reduces weight gain by increasing energy expenditure and leads to improved glucose metabolism. | 2017 | Details |
| A17429 | 27788706 | Zhonghua Gan Zang Bing Za Zhi | [Effects of celecoxib on expression of PPARγ and NF-κB in type 2 diabetes rats with non-alcoholic steatohepatitis]. | 2016 | Details |
| A17687 | 27658772 | Gastroenterology | Estrogen Signals Through Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease. | 2016 | Details |
| A17932 | 27470139 | Sci Rep | Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice. | 2016 | Details |
| A18327 | 27207512 | Diabetes | Variants in Genes Controlling Oxidative Metabolism Contribute to Lower Hepatic ATP Independent of Liver Fat Content in Type 1 Diabetes. | 2016 | Details |
| A18380 | 27173483 | Sci Rep | NADPH oxidase is implicated in the pathogenesis of oxidative phosphorylation dysfunction in mice fed a high-fat diet. | 2016 | Details |
| A18452 | 27125895 | AAPS J | Dual Outcomes of Rosiglitazone Treatment on Fatty Liver. | 2016 | Details |
| A18577 | 27051590 | BBA Clin | Diabetic and dyslipidaemic morbidly obese exhibit more liver alterations compared with healthy morbidly obese. | 2016 | Details |
| A18651 | 27015186 | Medicine (Baltimore) | Interactions of a PPARGC1A Variant and a PNPLA3 Variant Affect Nonalcoholic Steatohepatitis in Severely Obese Taiwanese Patients. | 2016 | Details |
| A18678 | 27002005 | Gut | Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease. | 2016 | Details |
| A18787 | 26941577 | Int J Med Sci | Palmitate-induced Regulation of PPARγ via PGC1α: a Mechanism for Lipid Accumulation in the Liver in Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A18848 | 26905378 | Appl Physiol Nutr Metab | Exercise mitigates mitochondrial permeability transition pore and quality control mechanisms alterations in nonalcoholic steatohepatitis. | 2015 | Details |
| A18860 | 26895665 | J Nutr Biochem | Liver-specific deletion of the signal transducer and activator of transcription 5 gene aggravates fatty liver in response to a high-fat diet in mice. | 2015 | Details |