Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Metformin577 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00147 | 35208513 | Medicina (Kaunas) | Evaluation of Dose-Dependent Obesity and Diabetes-Related Complications of Water Chestnut (Fruit of Trapa japonica) Extracts in Type II Obese Diabetic Mice Induced by 45% Kcal High-Fat Diet. | 2022 | Details |
| A00225 | 35176709 | Biomed Pharmacother | Purendan alleviates non-alcoholic fatty liver disease in aged type 2 diabetic rats via regulating mTOR/S6K1/SREBP-1c signaling pathway. | 2022 | Details |
| A00404 | 35100024 | Circulation | Salt-Induced Hepatic Inflammatory Memory Contributes to Cardiovascular Damage Through Epigenetic Modulation of SIRT3. | 2022 | Details |
| A00446 | 35080048 | J Gastroenterol Hepatol | Malaysian Society of Gastroenterology and Hepatology consensus statement on metabolic dysfunction-associated fatty liver disease. | 2022 | Details |
| A00459 | 35072848 | Inflammopharmacology | The effects of metformin, pioglitazone, exenatide and exercise on fatty liver in obese diabetic rats: the role of IRS-1 and SOCS-3 molecules. | 2022 | Details |
| A00589 | 35038311 | Eur J Endocrinol | Metformin maintains intrahepatic triglyceride content through increased hepatic de novo lipogenesis. | 2022 | Details |
| A00598 | 35035359 | Front Physiol | Exercise Alleviates the Apolipoprotein A5-Toll-Like Receptor 4 Axis Impairment in Mice With High-Fat Diet-Induced Non-alcoholic Steatohepatitis. | 2021 | Details |
| A00653 | 35014145 | Diabetes Obes Metab | Combination therapy with pioglitazone/exenatide/metformin reduces the prevalence of hepatic fibrosis and steatosis: The efficacy and durability of initial combination therapy for type 2 diabetes (EDICT). | 2022 | Details |
| A00662 | 35011585 | Cells | Cynanchum atratum Alleviates Non-Alcoholic Fatty Liver by Balancing Lipogenesis and Fatty Acid Oxidation in a High-Fat, High-Fructose Diet Mice Model. | 2021 | Details |
| A00708 | 34993571 | Diabetologia | Dietary carbohydrate restriction augments weight loss-induced improvements in glycaemic control and liver fat in individuals with type 2 diabetes: a randomised controlled trial. | 2022 | Details |
| A00759 | 34977520 | JHEP Rep | Real-world management of non-alcoholic steatohepatitis differs from clinical practice guideline recommendations and across regions. | 2021 | Details |
| A00764 | 34977118 | Front Nutr | Lactational High Fat Diet in Mice Causes Insulin Resistance and NAFLD in Male Offspring Which Is Partially Rescued by Maternal Metformin Treatment. | 2021 | Details |
| A01152 | 34853313 | Nat Commun | GP73 is a TBC-domain Rab GTPase-activating protein contributing to the pathogenesis of non-alcoholic fatty liver disease without obesity. | 2021 | Details |
| A01219 | 34825068 | Biochem Biophys Rep | Metformin treatment reverses high fat diet- induced non-alcoholic fatty liver diseases and dyslipidemia by stimulating multiple antioxidant and anti-inflammatory pathways. | 2021 | Details |
| A01347 | 34779535 | Hepatology | Effect of diabetes medications and glycemic control on risk of hepatocellular cancer in patients with nonalcoholic fatty liver disease. | 2021 | Details |
| A01537 | 34706542 | J Agric Food Chem | Sulforaphane Regulates Glucose and Lipid Metabolisms in Obese Mice by Restraining JNK and Activating Insulin and FGF21 Signal Pathways. | 2021 | Details |
| A01741 | 34630909 | World J Diabetes | Effectiveness of drug interventions in nonalcoholic fatty liver disease: A network meta-analysis. | 2021 | Details |
| A01861 | 34585409 | J Food Biochem | Crataegus aronia prevents high-fat diet-induced hepatic steatosis in rats by activating AMPK-induced suppression of SREBP1 and activation of PPARα. | 2021 | Details |
| A01948 | 34557367 | Cureus | Non-Alcoholic Fatty Liver Disease and Its Association With Diabetes Mellitus. | 2021 | Details |
| A02006 | 34533249 | Phytother Res | The effects of co-administration of artichoke leaf extract supplementation with metformin and vitamin E in patients with nonalcoholic fatty liver disease: A randomized clinical trial. | 2021 | Details |
| A02128 | 34496884 | Lipids Health Dis | Metformin ameliorates maternal high-fat diet-induced maternal dysbiosis and fetal liver apoptosis. | 2021 | Details |
| A02156 | 34483906 | Front Pharmacol | Metformin Alleviates Steatohepatitis in Diet-Induced Obese Mice in a SIRT1-Dependent Way. | 2021 | Details |
| A02366 | 34401141 | Ann Med Surg (Lond) | Prevalence of fatty liver disease and its associated factors among Jordanian patients with type 2 diabetes mellitus: A cross-sectional study. | 2021 | Details |
| A02370 | 34400208 | J Pediatr | Relationship of Enhanced Liver Fibrosis Score with Pediatric Nonalcoholic Fatty Liver Disease Histology and Response to Vitamin E or Metformin. | 2021 | Details |
| A02418 | 34381196 | Nat Rev Endocrinol | GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease. | 2021 | Details |
| A02451 | 34366846 | Front Pharmacol | Metformin Alleviates Hepatic Steatosis and Insulin Resistance in a Mouse Model of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Promoting Transcription Factor EB-Dependent Autophagy. | 2021 | Details |
| A02574 | 34326020 | Surg Obes Relat Dis | Metabolic surgery may protect against admission for COVID-19 in persons with nonalcoholic fatty liver disease. | 2021 | Details |
| A02609 | 34311022 | Diabetes Res Clin Pract | Pioglitazone even at low dosage improves NAFLD in type 2 diabetes: clinical and pathophysiological insights from a subgroup of the TOSCA.IT randomised trial. | 2021 | Details |
| A02827 | 34227216 | Diabetes Obes Metab | Impact of SGLT2 inhibitors in comparison with DPP4 inhibitors on ascites and death in veterans with cirrhosis on metformin. | 2021 | Details |
| A02831 | 34226120 | Nutr Metab Cardiovasc Dis | Insulin resistance and NAFLD may influence memory performance in obese patients with prediabetes or newly-diagnosed type 2 diabetes. | 2021 | Details |
| A02955 | 34185201 | Inflammopharmacology | Molecular and pathobiological involvement of fetuin-A in the pathogenesis of NAFLD. | 2021 | Details |
| A02974 | 34177796 | Front Endocrinol (Lausanne) | Sodium-Glucose Cotransporter-2 Inhibitors Ameliorate Liver Enzyme Abnormalities in Korean Patients With Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03002 | 34168429 | Drug Des Devel Ther | Metformin in Combination with Malvidin Prevents Progression of Non-Alcoholic Fatty Liver Disease via Improving Lipid and Glucose Metabolisms, and Inhibiting Inflammation in Type 2 Diabetes Rats. | 2021 | Details |
| A03016 | 34162924 | Sci Rep | Validation of an adipose-liver human-on-a-chip model of NAFLD for preclinical therapeutic efficacy evaluation. | 2021 | Details |
| A03126 | 34119888 | Biomaterials | A scalable and sensitive steatosis chip with long-term perfusion of in situ differentiated HepaRG organoids. | 2021 | Details |
| A03271 | 34065108 | Int J Mol Sci | Metformin Actions on the Liver: Protection Mechanisms Emerging in Hepatocytes and Immune Cells against NASH-Related HCC. | 2021 | Details |
| A03310 | 34049870 | BMJ Open Diabetes Res Care | Variables associated with increased incidence of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes. | 2021 | Details |
| A03431 | 34002333 | Diabetes Ther | Effects of Liraglutide on Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. | 2021 | Details |
| A03484 | 33987424 | Ann Transl Med | Non-alcoholic fatty liver diseases: current challenges and future directions. | 2021 | Details |
| A03704 | 33897616 | Front Endocrinol (Lausanne) | Glucagon-Like Peptide-1 Receptor Agonists for Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: A Meta-Analysis. | 2021 | Details |
| A03740 | 33882758 | Expert Rev Clin Pharmacol | Effects of anti-diabetic treatments in type 2 diabetes and fatty liver disease. | 2021 | Details |
| A03813 | 33859820 | Biomed Rep | Effects of obesity and 10 weeks metformin treatment on liver steatosis. | 2021 | Details |
| A03840 | 33852508 | Eur J Gastroenterol Hepatol | The role of nursing care in the type 2 diabetes treatment associated with chronic liver diseases. | 2022 | Details |
| A03858 | 33844015 | Toxicol Sci | Perfluorooctanesulfonic Acid (PFOS) Thwarts the Beneficial Effects of Calorie Restriction and Metformin. | 2021 | Details |
| A03861 | 33841337 | Front Endocrinol (Lausanne) | Efficacy of Various Hypoglycemic Agents in the Treatment of Patients With Nonalcoholic Liver Disease With or Without Diabetes： A Network Meta-Analysis. | 2021 | Details |
| A03891 | 33831691 | Phytomedicine | Therapeutic effect of oxyberberine on obese non-alcoholic fatty liver disease rats. | 2021 | Details |
| A03914 | 33820884 | Gut Liver | Effects of Metformin on Hepatic Steatosis in Adults with Nonalcoholic Fatty Liver Disease and Diabetes: Insights from the Cellular to Patient Levels. | 2021 | Details |
| A04068 | 33771699 | Pharmacol Res | Epigenetics in NAFLD/NASH: Targets and therapy. | 2021 | Details |
| A04106 | 33755449 | J Agric Food Chem | Gut Microbiota and Its Metabolite Deoxycholic Acid Contribute to Sucralose Consumption-Induced Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A04199 | 33719959 | Curr Pharm Des | The Effect of Metformin on Aminotransferase Levels, Metabolic Parameters and Body Mass Index in Nonalcoholic Fatty Liver Disease Patients: A Metaanalysis. | 2021 | Details |
| A04285 | 33678036 | Hum Exp Toxicol | Early intervention with probiotics and metformin alleviates liver injury in NAFLD rats via targeting gut microbiota dysbiosis and p-AKT/mTOR/LC-3II pathways. | 2021 | Details |
| A04402 | 33632113 | Endocr Metab Immune Disord Drug Targets | Effects of Metformin-Single Therapy on the Level of Inflammatory Markers in Serum of Non-Obese T2DM Patients with NAFLD. | 2022 | Details |
| A04420 | 33622853 | mSystems | Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice. | 2021 | Details |
| A04439 | 33616043 | J Diabetes Complications | Evolution of liver fibrosis and steatosis markers in patients with type 2 diabetes after metformin treatment for 2 years. | 2020 | Details |
| A04478 | 33601426 | Exp Clin Endocrinol Diabetes | Impact of Non-Alcoholic Fatty Liver Disease on Metabolic Comorbidities in Type 2 Diabetes Mellitus. | 2021 | Details |
| A04537 | 33584555 | Front Microbiol | The Therapeutic Efficacy of Curcumin vs. Metformin in Modulating the Gut Microbiota in NAFLD Rats: A Comparative Study. | 2021 | Details |
| A04609 | 33564655 | Clin Nutr Res | Effect of Chlorella vulgaris on Liver Function Biomarkers: a Systematic Review and Meta-Analysis. | 2021 | Details |
| A04614 | 33562458 | Pharmaceuticals (Basel) | The Current and Potential Therapeutic Use of Metformin-The Good Old Drug. | 2021 | Details |
| A04750 | 33515696 | Cell Signal | Coordinated regulation of miR-27 by insulin/CREB/Hippo contributes to insulin resistance. | 2021 | Details |
| A04814 | 33497019 | Liver Int | Effects of antidiabetic agents on steatosis and fibrosis biomarkers in type 2 diabetes: A real-world data analysis. | 2021 | Details |
| A04892 | 33464703 | Diabetes Obes Metab | Combined exenatide and dapagliflozin has no additive effects on reduction of hepatocellular lipids despite better glycaemic control in patients with type 2 diabetes mellitus treated with metformin: EXENDA, a 24-week, prospective, randomized, placebo-controlled pilot trial. | 2021 | Details |
| A05008 | 33413060 | Curr Med Chem | Lipid Metabolism and Relevant Disorders to Female Reproductive Health. | 2021 | Details |
| A05041 | 33397230 | Curr Pharm Des | Serum Uric Acid and Diabetes: From Pathophysiology to Cardiovascular Disease. | 2021 | Details |
| A05244 | 33326684 | IUBMB Life | Combination of metformin and chlorogenic acid attenuates hepatic steatosis and inflammation in high-fat diet fed mice. | 2020 | Details |
| A05407 | 33269017 | J Med Biochem | Pentoxifylline with metformin treatment improves biochemical parameters in patients with nonalcoholic steatohepatitis. | 2020 | Details |
| A05423 | 33262120 | Diabetes | A High-Fat Diet Attenuates AMPK α1 in Adipocytes to Induce Exosome Shedding and Nonalcoholic Fatty Liver Development In Vivo. | 2020 | Details |
| A05485 | 33236464 | Diabetes Obes Metab | Metformin dose increase versus added linagliptin in non-alcoholic fatty liver disease and type 2 diabetes: An analysis of the J-LINK study. | 2020 | Details |
| A05645 | 33177546 | Sci Rep | PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat. | 2020 | Details |
| A05649 | 33173745 | Adv Sci (Weinh) | The Nuclear Orphan Receptor NR2F6 Promotes Hepatic Steatosis through Upregulation of Fatty Acid Transporter CD36. | 2020 | Details |
| A05680 | 33162737 | Ann Gastroenterol | Nonalcoholic fatty liver disease and atrial fibrillation: possible pathophysiological links and therapeutic interventions. | 2020 | Details |
| A05712 | 33145423 | Clin Exp Hepatol | Hepatocellular carcinoma in patients with non-alcoholic steatohepatitis - epidemiology, risk factors, clinical implications and treatment. | 2020 | Details |
| A05973 | 33055335 | Wiad Lek | APOPTOTIC PROCESSES' RESEARCH ON THE MODEL OF TYPE 2 DIABETES MELLITUS ON OBESITY'S BACKGROUND UNDER THE INFLUENCE OF DENSE BEAN EXTRACT. | 2020 | Details |
| A06027 | 33035599 | Diabetes Res Clin Pract | Liraglutide or insulin glargine treatments improves hepatic fat in obese patients with type 2 diabetes and nonalcoholic fatty liver disease in twenty-six weeks: A randomized placebo-controlled trial. | 2020 | Details |
| A06074 | 33015726 | Curr Diab Rep | Role of Agents for the Treatment of Diabetes in the Management of Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A06218 | 32964054 | J Diabetes Res | Association between Thyroid Function and Nonalcoholic Fatty Liver Disease in Euthyroid Type 2 Diabetes Patients. | 2020 | Details |
| A06240 | 32956824 | J Nutr Biochem | Combination of metformin and genistein alleviates non-alcoholic fatty liver disease in high-fat diet-fed mice. | 2020 | Details |
| A06263 | 32947952 | Nutrients | Anti-Diabetic Obesity Effects of Wasabia Japonica Matsum Leaf Extract on 45% Kcal High-Fat Diet-Fed Mice. | 2020 | Details |
| A06360 | 32916379 | Nutrition | Pleiotropic ameliorative effects of ellagitannin geraniin against metabolic syndrome induced by high-fat diet in rats. | 2020 | Details |
| A06373 | 32909011 | medRxiv | Non-alcoholic fatty liver disease (NAFLD) and risk of hospitalization for Covid-19. | 2020 | Details |
| A06397 | 32893589 | Zhongguo Zhong Yao Za Zhi | [Effect and mechanism of Bidens pilosa decoction on non-alcoholic fatty liver induced by high fat and high glucose in mice]. | 2020 | Details |
| A06447 | 32879136 | JCI Insight | Hepatic lipids promote liver metastasis. | 2020 | Details |
| A06594 | 32814993 | Curr Gastroenterol Rep | Emerging New Diagnostic Modalities and Therapies of Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A06633 | 32800550 | Biochem Biophys Res Commun | Metformin, resveratrol, and exendin-4 inhibit high phosphate-induced vascular calcification via AMPK-RANKL signaling. | 2020 | Details |
| A06637 | 32798709 | Clin Gastroenterol Hepatol | Effects of Metformin Exposure on Survival in a Large National Cohort of Patients With Diabetes and Cirrhosis. | 2020 | Details |
| A06756 | 32758573 | Eur J Pharmacol | Gut microbiota modulation as a promising therapy with metformin in rats with non-alcoholic steatohepatitis: Role of LPS/TLR4 and autophagy pathways. | 2020 | Details |
| A06965 | 32684739 | World J Gastroenterol | Medications in type-2 diabetics and their association with liver fibrosis. | 2020 | Details |
| A06984 | 32673798 | Mol Metab | Non-alcoholic fatty liver disease and steatohepatitis: State of the art on effective therapeutics based on the gold standard method for diagnosis. | 2020 | Details |
| A07066 | 32634622 | Clin Gastroenterol Hepatol | Real-World Burden of Nonalcoholic Steatohepatitis. | 2020 | Details |
| A07152 | 32598715 | Ter Arkh | [Evaluation of the effectiveness of differentiated therapy of non-alcoholic fatty liver disease]. | 2020 | Details |
| A07355 | 32526850 | Molecules | The Potential Therapeutic Value of Medicinal Plants in the Management of Metabolic Disorders. | 2020 | Details |
| A07424 | 32505776 | Clin Chim Acta | Intestinal microbiota-farnesoid X receptor axis in metabolic diseases. | 2020 | Details |
| A07454 | 32489856 | Integr Med Res | Herbal formulation MIT ameliorates high-fat diet-induced non-alcoholic fatty liver disease. | 2020 | Details |
| A07609 | 32424494 | Adv Exp Med Biol | Non-alcoholic Fatty Liver Disease and Diabetes Mellitus. | 2021 | Details |
| A07693 | 32389886 | Clin Gastroenterol Hepatol | Type 2 Diabetes and Metformin Use Associate With Outcomes of Patients With Nonalcoholic Steatohepatitis-Related, Child-Pugh A Cirrhosis. | 2020 | Details |
| A07814 | 32348835 | Life Sci | Exenatide ameliorates experimental non-alcoholic fatty liver in rats via suppression of toll-like receptor 4/NFκB signaling: Comparison to metformin. | 2020 | Details |
| A08023 | 32278041 | Pharmacol Res | The effects of metformin administration on liver enzymes and body composition in non-diabetic patients with non-alcoholic fatty liver disease and/or non-alcoholic steatohepatitis: An up-to date systematic review and meta-analysis of randomized controlled trials. | 2020 | Details |
| A08033 | 32274915 | Minerva Pediatr | Metabolic syndrome in children. | 2020 | Details |
| A08145 | 32229588 | J Lipid Res | The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice. | 2020 | Details |
| A08235 | 32191400 | Clin Pharmacol Drug Dev | Pharmacokinetics and Pharmacodynamics of Ursodeoxycholic Acid in an Overweight Population With Abnormal Liver Function. | 2020 | Details |
| A08258 | 32184858 | Iran J Pharm Res | In-vitro Synergistic Effect of Metformin and Berberine on High Glucose-induced Lipogenesis. | 2019 | Details |