Repositioning Candidates
Repositioning candidates for NAFLD are derived from DrugBank which fall into three categories: therapeutic strategy-associated, target-associated, and indication-associated candidates. For each candidate, detailed properties are extracted from DrugBank, and related strategies, target and NAFLD-associated disease in NAFLDkb are presented with knowledge graphs.
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Peroxisome proliferator-activated receptor gamma65 records.
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0043 | DB00132 | approved; investigational; nutraceutical | small molecule | alpha-Linolenic acid | Therapeutic strategy associated | Details |
| R0056 | DB00159 | approved; nutraceutical | small molecule | Icosapent | Therapeutic strategy associated | Details |
| R0093 | DB00244 | approved | small molecule | Mesalazine | Therapeutic strategy associated | Details |
| R0112 | DB00313 | approved; investigational | small molecule | Valproic acid | Therapeutic strategy associated | Details |
| R0117 | DB00328 | approved; investigational | small molecule | Indomethacin | Therapeutic strategy associated | Details |
| R0197 | DB00573 | approved | small molecule | Fenoprofen | Target associated | Details |
| R0257 | DB00731 | approved; investigational | small molecule | Nateglinide | Target associated | Details |
| R0282 | DB00795 | approved | small molecule | Sulfasalazine | Therapeutic strategy associated | Details |
| R0306 | DB00845 | approved; investigational | small molecule | Clofazimine | Therapeutic strategy associated | Details |
| R0330 | DB00912 | approved; investigational | small molecule | Repaglinide | Target associated | Details |
| R0369 | DB01014 | approved; investigational | small molecule | Balsalazide | Therapeutic strategy associated | Details |
| R0385 | DB01050 | approved | small molecule | Ibuprofen | Target associated | Details |
| R0391 | DB01067 | approved; investigational | small molecule | Glipizide | Therapeutic strategy associated | Details |
| R0413 | DB01118 | approved; investigational | small molecule | Amiodarone | Target associated | Details |
| R0468 | DB01252 | investigational | small molecule | Mitiglinide | Target associated | Details |
| R0560 | DB02266 | approved | small molecule | Flufenamic acid | Target associated | Details |
| R0570 | DB02746 | experimental | small molecule | Phthalic Acid | Target associated | Details |
| R0588 | DB03600 | experimental | small molecule | Capric acid | Target associated | Details |
| R0597 | DB04224 | approved; investigational; vet_approved | small molecule | Oleic Acid | Target associated | Details |
| R0598 | DB04270 | experimental | small molecule | (S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid | Target associated | Details |
| R0611 | DB04689 | experimental | small molecule | 2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID | Target associated | Details |
| R0664 | DB04971 | investigational | small molecule | Reglitazar | Target associated | Details |
| R0816 | DB05490 | investigational | small molecule | AMG-131 | Target associated | Details |
| R0886 | DB05854 | investigational | small molecule | CLX-0921 | Target associated | Details |
| R1034 | DB06510 | investigational | small molecule | Muraglitazar | Target associated | Details |
| R1038 | DB06521 | investigational | small molecule | Ertiprotafib | Target associated | Details |
| R1041 | DB06533 | investigational | small molecule | Ragaglitazar | Target associated | Details |
| R1042 | DB06536 | investigational | small molecule | Tesaglitazar | Target associated | Details |
| R1110 | DB06908 | experimental | small molecule | (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID | Target associated | Details |
| R1111 | DB06926 | experimental | small molecule | (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid | Target associated | Details |
| R1112 | DB07053 | experimental | small molecule | 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID | Target associated | Details |
| R1114 | DB07111 | experimental | small molecule | (4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid | Target associated | Details |
| R1115 | DB07172 | experimental | small molecule | (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid | Target associated | Details |
| R1116 | DB07208 | experimental | small molecule | (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid | Target associated | Details |
| R1117 | DB07209 | experimental | small molecule | (8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid | Target associated | Details |
| R1119 | DB07302 | experimental | small molecule | 9(S)-HODE | Target associated | Details |
| R1121 | DB07509 | experimental | small molecule | difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron | Target associated | Details |
| R1123 | DB07675 | experimental | small molecule | (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID | Target associated | Details |
| R1126 | DB07723 | experimental | small molecule | 3-(5-methoxy-1H-indol-3-yl)propanoic acid | Target associated | Details |
| R1127 | DB07724 | experimental | small molecule | Indeglitazar | Target associated | Details |
| R1130 | DB07842 | experimental | small molecule | (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid | Target associated | Details |
| R1131 | DB07863 | experimental | small molecule | 2-chloro-5-nitro-N-phenylbenzamide | Target associated | Details |
| R1136 | DB08121 | experimental | small molecule | (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid | Target associated | Details |
| R1142 | DB08302 | experimental | small molecule | 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid | Target associated | Details |
| R1143 | DB08402 | experimental | small molecule | 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID | Target associated | Details |
| R1144 | DB08435 | experimental | small molecule | (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid | Target associated | Details |
| R1148 | DB08560 | experimental | small molecule | 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE | Target associated | Details |
| R1149 | DB08604 | approved; investigational | small molecule | Triclosan | Target associated | Details |
| R1150 | DB08760 | experimental | small molecule | (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid | Target associated | Details |
| R1187 | DB08915 | investigational | small molecule | Aleglitazar | Target associated | Details |
| R1192 | DB09006 | experimental | small molecule | Clinofibrate | Target associated | Details |
| R1208 | DB09061 | approved; investigational | small molecule | Cannabidiol | Therapeutic strategy associated | Details |
| R1240 | DB09201 | experimental | small molecule | Ciglitazone | Target associated | Details |
| R1244 | DB09213 | approved; investigational | small molecule | Dexibuprofen | Therapeutic strategy associated | Details |
| R1396 | DB11721 | investigational | small molecule | Mitoglitazone | Target associated | Details |
| R1407 | DB11811 | investigational | small molecule | Arhalofenate | Target associated | Details |
| R1427 | DB12007 | experimental | small molecule | Isoflavone | Therapeutic strategy associated | Details |
| R1459 | DB12662 | investigational | small molecule | Naveglitazar | Target associated | Details |
| R1497 | DB13873 | approved | small molecule | Fenofibric acid | Target associated | Details |
| R1513 | DB14009 | experimental; investigational | biotech | Medical Cannabis | Target associated | Details |
| R1514 | DB14011 | investigational | small molecule | Nabiximols | Target associated | Details |
| R1516 | DB14034 | experimental | small molecule | Darglitazone | Target associated | Details |
| R1535 | DB14635 | experimental | small molecule | Curcumin sulfate | Therapeutic strategy associated | Details |
| R1552 | DB15021 | investigational | small molecule | Leriglitazone | Target associated | Details |
| R1588 | DB16028 | investigational | small molecule | Azemiglitazone | Target associated | Details |