Repositioning Candidates
Repositioning candidates for NAFLD are derived from DrugBank which fall into three categories: therapeutic strategy-associated, target-associated, and indication-associated candidates. For each candidate, detailed properties are extracted from DrugBank, and related strategies, target and NAFLD-associated disease in NAFLDkb are presented with knowledge graphs.
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PPAR47 records.
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0043 | DB00132 | approved; investigational; nutraceutical | small molecule | alpha-Linolenic acid | Therapeutic strategy associated | Details |
| R0065 | DB00178 | approved | small molecule | Ramipril | Therapeutic strategy associated | Details |
| R0093 | DB00244 | approved | small molecule | Mesalazine | Therapeutic strategy associated | Details |
| R0170 | DB00492 | approved | small molecule | Fosinopril | Indication associated | Details |
| R0174 | DB00509 | approved; investigational | small molecule | Dextrothyroxine | Target associated | Details |
| R0175 | DB00519 | approved | small molecule | Trandolapril | Indication associated | Details |
| R0226 | DB00636 | approved; investigational | small molecule | Clofibrate | Target associated | Details |
| R0240 | DB00691 | approved | small molecule | Moexipril | Indication associated | Details |
| R0283 | DB00796 | approved | small molecule | Candesartan cilexetil | Target associated | Details |
| R0290 | DB00812 | approved; vet_approved | small molecule | Phenylbutazone | Therapeutic strategy associated | Details |
| R0314 | DB00866 | experimental; withdrawn | small molecule | Alprenolol | Indication associated | Details |
| R0332 | DB00920 | approved | small molecule | Ketotifen | Therapeutic strategy associated | Details |
| R0333 | DB00922 | approved; investigational | small molecule | Levosimendan | Indication associated | Details |
| R0346 | DB00960 | approved; investigational | small molecule | Pindolol | Indication associated | Details |
| R0414 | DB01119 | approved | small molecule | Diazoxide | Indication associated | Details |
| R0444 | DB01197 | approved | small molecule | Captopril | Indication associated | Details |
| R0446 | DB01203 | approved | small molecule | Nadolol | Indication associated | Details |
| R0532 | DB01580 | approved | small molecule | Oxprenolol | Indication associated | Details |
| R0629 | DB04861 | approved; investigational | small molecule | Nebivolol | Therapeutic strategy associated | Details |
| R0664 | DB04971 | investigational | small molecule | Reglitazar | Target associated | Details |
| R0715 | DB05140 | investigational | biotech | RAV12 | Therapeutic strategy associated | Details |
| R0727 | DB05188 | investigational | small molecule | KD3010 | Target associated | Details |
| R0789 | DB05416 | investigational | small molecule | Cardarine | Target associated | Details |
| R0816 | DB05490 | investigational | small molecule | AMG-131 | Target associated | Details |
| R0930 | DB06148 | approved; investigational | small molecule | Mianserin | Indication associated | Details |
| R1034 | DB06510 | investigational | small molecule | Muraglitazar | Target associated | Details |
| R1038 | DB06521 | investigational | small molecule | Ertiprotafib | Target associated | Details |
| R1058 | DB06606 | investigational | biotech | Teplizumab | Indication associated | Details |
| R1085 | DB06709 | approved; investigational | small molecule | Methacholine | Therapeutic strategy associated | Details |
| R1153 | DB08807 | experimental | small molecule | Bopindolol | Indication associated | Details |
| R1187 | DB08915 | investigational | small molecule | Aleglitazar | Target associated | Details |
| R1189 | DB08932 | approved | small molecule | Macitentan | Indication associated | Details |
| R1231 | DB09130 | approved; investigational | small molecule | Copper | Therapeutic strategy associated | Details |
| R1240 | DB09201 | experimental | small molecule | Ciglitazone | Target associated | Details |
| R1276 | DB09267 | approved; withdrawn | small molecule | Strontium ranelate | Therapeutic strategy associated | Details |
| R1309 | DB09422 | approved | biotech | Soybean oil | Therapeutic strategy associated | Details |
| R1345 | DB11160 | approved | small molecule | Phenyltoloxamine | Therapeutic strategy associated | Details |
| R1358 | DB11254 | approved | small molecule | Hexylresorcinol | Therapeutic strategy associated | Details |
| R1378 | DB11582 | experimental | small molecule | Thiocolchicoside | Target associated | Details |
| R1407 | DB11811 | investigational | small molecule | Arhalofenate | Target associated | Details |
| R1427 | DB12007 | experimental | small molecule | Isoflavone | Therapeutic strategy associated | Details |
| R1437 | DB12169 | approved; investigational | biotech | Tralokinumab | Therapeutic strategy associated | Details |
| R1443 | DB12332 | approved; investigational | small molecule | Rucaparib | Therapeutic strategy associated | Details |
| R1483 | DB13168 | nutraceutical | small molecule | Omega-6 fatty acids | Therapeutic strategy associated | Details |
| R1491 | DB13501 | approved; withdrawn | small molecule | Bendazac | Therapeutic strategy associated | Details |
| R1497 | DB13873 | approved | small molecule | Fenofibric acid | Target associated | Details |
| R1503 | DB13931 | approved | small molecule | Netarsudil | Therapeutic strategy associated | Details |