Bioactive Compound Details
| Compound ID: | B117639 |
| Source ID: | CHEMBL267345 |
| Source Type: | Small molecule |
| Compound Name: | AMPHOTERICIN B |
| Synonyms: | AMBIL|AMOPHOTERICIN B|AMPHO-MORONAL|AMPHOTERCIN B|AMPHOTERICIN|AMPHOTERICIN B|AMPHOTERICIN B DEOXYCHOLATE|AMPHOTERICIN B LIPID COMPLEX|AMPHOTERICIN B LIPOSOMAL|AMPHOTERICIN B LIPOSOMAL COMPLEX|AMPHOTERICIN B LIPOSOME|AMPHOTERICIN B, LIPOSOME|AMPHOTERICINE B|AMPHOTERICINUM B|AMPHOTERICITIN B|AMPHOTOCERIN|AMPHOTREICIN B|AMPOTERICIN B|Abelcet|Ambisome|Amphotec|FUNGILIN|FUNGILIN IN ORABASE|Fungizone|HALIZON|NSC-527017 |
| Molecular Formula: | C47H73NO17 |
| SMILES: | C[C@@H]1OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@]2(O)C[C@H](O)[C@@H](C(=O)O)[C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@H]1C)O2 |
| Molecular Species: | ZWITTERION |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T07 | Bile acid receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |
| T17 | Farnesoid X-activated receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |
| T04 | Peroxisome proliferator-activated receptor delta | PPARD | agonist | Nuclear hormone receptor | Q03181 | PPARD_HUMAN | Details |
| T08 | Tumor necrosis factor | TNF | inhibitor | Cytokine | P01375 | TNFA_HUMAN | Details |