Bioactive Compound Details
| Compound ID: | B144627 |
| Source ID: | CHEMBL6 |
| Source Type: | Small molecule |
| Compound Name: | INDOMETHACIN |
| Synonyms: | ACONIP|ARTRACIN|ARTRACIN SR|BERLIND 75 RET|DURAMETACIN|FLEXIN-25 CONTINUS|FLEXIN-50 CONTINUS|FLEXIN-75 CONTINUS|IMBRILON|INDO-LEMMON|INDO-PAED|INDOCID RET|INDOCID-R|INDOCIN SR|INDODERM|INDOFLEX|INDOLAR|INDOLAR SR|INDOMAX-25|INDOMAX-75 SR|INDOMETACIN|INDOMETACIN FARNESIL|INDOMETACINUM|INDOMETHACIN|INDOMOD|INDOPTOL|INDOTARD MR 75|Indocin|LEDMECIN|MAXIMET SR|MOBILAN|NSC-757061|NSC-77541|PARDELPRIN MR|REUMACIDE|RHEUMACIN LA|RIMACID|SLO-INDO|TIVORBEX |
| Molecular Formula: | C19H16ClNO4 |
| SMILES: | COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1 |
| Molecular Species: | ACID |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T07 | Bile acid receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |
| T17 | Farnesoid X-activated receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |
| T04 | Peroxisome proliferator-activated receptor delta | PPARD | agonist | Nuclear hormone receptor | Q03181 | PPARD_HUMAN | Details |
| T05 | Peroxisome proliferator-activated receptor gamma | PPARG | agonist | Nuclear hormone receptor | P37231 | PPARG_HUMAN | Details |
| T26 | Thyroid hormone receptor beta | THRB | agonist | Nuclear hormone receptor | P10828 | THB_HUMAN | Details |
| T45 | Arachidonate 12-lipoxygenase | ALOX12 | inhibitor | Enzyme | P18054 | LOX12_HUMAN | Details |