Investigational Drugs
Investigational drugs for NAFLD are derived from global clinical trials with the latest progress, and detailed drug properties are extracted from DrugBank and PubChem. For each drug, related therapeutic strategies, targets, and clinical trials in NAFLDkb are presented with knowledge graphs.
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581 records.
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D589 | Minor allele-specific small interfering RNA | Miscellany | -- | PNPLA3-rs738409 (I148M) variant inhibitor | -- | Under investigation | Details |
| D590 | Polaprezinc | Chemical drug | -- | Lipid peroxidation inhibitors | Anti-oxidative stress | Under investigation | Details |
| D591 | Matrine | Miscellany | -- | -- | Anti-oxidative stress | Under investigation | Details |
| D592 | Ncst ASO | Miscellany | -- | Notch inhibitor | Anti-fibrosis | Under investigation | Details |
| D593 | GSI | Miscellany | -- | Notch inhibitor | Anti-fibrosis | Under investigation | Details |
| D594 | GalNAc-siTAZ | Miscellany | -- | TAZ inhibitor | Anti-fibrosis | Under investigation | Details |
| D595 | AAV8-ALB-hHNF 4α | Miscellany | -- | -- | Anti-fibrosis | Under investigation | Details |
| D596 | Emodin | Chemical drug | -- | DNA synthesis inhibitors; Protein synthesis inhibitors; Protein tyrosine kinase inhibitors; RNA synthesis inhibitors | Anti-fibrosis | Under investigation | Details |
| D597 | Yellow loosestrife | Herbal medicine | -- | -- | Anti-fibrosis | Under investigation | Details |
| D598 | Tetrodecadazinone | Chemical drug | -- | -- | Anti-fibrosis | Under investigation | Details |
| D599 | TIPE2 | Miscellany | -- | -- | Anti-fibrosis | Under investigation | Details |
| D600 | Oxy210 | Chemical drug | -- | Hedgehog cell-signalling pathway inhibitors; Transforming growth factor beta inhibitors; Virus replication inhibitors | Anti-fibrosis | Under investigation | Details |
| D601 | SP-1154 | Miscellany | -- | -- | Anti-fibrosis | Under investigation | Details |
| D602 | IGF-I | Miscellany | -- | P53 activitor | Anti-fibrosis | Under investigation | Details |
| D603 | Ravoxertinib | Chemical drug | -- | Extracellular signal-regulated MAP kinase inhibitors; Mitogen activated protein kinase 3 inhibitors; Mitogen-activated protein kinase 1 inhibitors | Anti-inflammatory | Under investigation | Details |
| D604 | FR180204 | Miscellany | -- | -- | Anti-inflammatory | Under investigation | Details |
| D605 | Sulforaphen | Miscellany | -- | NLRP3 inhibitor | Anti-inflammatory | Under investigation | Details |
| D606 | Sparstolonin B | Miscellany | -- | TLR4 antagonist | Anti-inflammatory | Under investigation | Details |
| D607 | Anti-IL11 | Biological drug | -- | IL11 antibody | Anti-inflammatory | Under investigation | Details |
| D608 | anti-IL11RA | Biological drug | -- | IL11 antibody | Anti-inflammatory | Under investigation | Details |
| D609 | Annexin A5 | Miscellany | -- | -- | Anti-inflammatory | Under investigation | Details |
| D610 | Thalidomide | Chemical drug | -- | Tumour necrosis factor inhibitors | Antifibrotics; Antileprotics; Antineoplastics; Anti-inflammatory | Under investigation | Details |
| D611 | Infliximab | Biological drug | -- | Tumour necrosis factor alpha inhibitors | Anti-inflammatories | Under investigation | Details |
| D612 | Rapamycin | Miscellany | -- | Immunosuppressants; Methylmalonyl CoA mutase stimulants; MTOR protein inhibitors; T lymphocyte inhibitors | -- | Under investigation | Details |
| D613 | shRNA against ATG3 | Biological drug | -- | ATG3 inhibitor | -- | Under investigation | Details |
| D614 | Flavopiridol | Chemical drug | -- | Cyclin dependent kinase 9 inhibitors | Antineoplastics | Under investigation | Details |
| D615 | PD-0332991 | Chemical drug | -- | Cyclin-dependent kinase 4 inhibitors; Cyclin-dependent kinase 6 inhibitors | -- | Under investigation | Details |
| D616 | ECH1 | Miscellany | -- | Ferroptosis inhibitor | Anti-apoptosis | Under investigation | Details |
| D617 | Glutathione S-transferase Mu 2 | Miscellany | -- | ASK1 inhibitor | Anti-apoptosis | Under investigation | Details |
| D618 | Adeno-associated virus 8 (AAV8)-TNFAIP3 injection | Miscellany | -- | ASK1 inhibitor | Anti-apoptosis | Under investigation | Details |
| D619 | Peptide fragment of CFLAR | Biological drug | -- | ASK1 inhibitor | Anti-apoptosis | Under investigation | Details |