Investigational Drugs
Investigational drugs for NAFLD are derived from global clinical trials with the latest progress, and detailed drug properties are extracted from DrugBank and PubChem. For each drug, related therapeutic strategies, targets, and clinical trials in NAFLDkb are presented with knowledge graphs.
stats1
stats2
Search for:
Cardiovascular36 records.
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D008 | Alpha-tocopherol | Chemical drug | DB00163 | NR1I2; ALOX5; DGKA | -- | Under clinical trials | Details |
| D018 | Aspirin | Chemical drug | DB00945 | AKR1C1 inhibitor; PCNA downregulator | Enhance lipid metabolism | Under clinical trials | Details |
| D020 | Atorvastatin | Chemical drug | DB01076 | DPP4 inhibitor; AHR agonist; HDAC2 inhibitor; NR1I3 ligand | Enhance lipid metabolism | Under clinical trials | Details |
| D058 | Canagliflozin | Chemical drug | DB08907 | SGLT2 inhibitor | Improve insulin resistance | Under clinical trials | Details |
| D075 | Choline | Supplement | DB00122 | PLD2 product of; PLD1 product of | -- | Under clinical trials | Details |
| D080 | Citrulline | Chemical drug | DB00155 | -- | -- | Under clinical trials | Details |
| D084 | Coenzyme Q10 | Chemical drug | DB09270 | -- | -- | Under clinical trials | Details |
| D085 | Colesevelam | Chemical drug | DB00930 | -- | Anticholesteremic drug | Under clinical trials | Details |
| D112 | Digoxin | Chemical drug | DB00390 | ATP1A1 inhibitor; ATP1A2 inhibitor; ATP1A3 inhibitor; ATP1A4 inhibitor | Antiarrhythmic | Under clinical trials | Details |
| D115 | DS102 | Miscellany | -- | -- | -- | Under clinical trials | Details |
| D116 | Dulaglutide | Biological drug | DB09045 | GLP1R agonist | Improve insulin resistance | Under clinical trials | Details |
| D122 | Empagliflozin | Chemical drug | DB09038 | SLC5A2 inhibitor; SGLT-2 inhibitor | Improve insulin resistance | Under clinical trials | Details |
| D125 | Epanova | Chemical drug | DB11133 | PPARG ligand; PPARA activator | Enhance lipid metabolism | Under clinical trials | Details |
| D131 | Ezetimibe | Chemical drug | DB00973 | SOAT1 inhibitor; | Enhance lipid metabolism | Under clinical trials | Details |
| D137 | Fish oil | Biological drug | DB13961 | -- | -- | Under clinical trials | Details |
| D140 | Folic acid | Supplement | DB00158 | FOLR2 binder | -- | Under clinical trials | Details |
| D149 | Gemcabene | Chemical drug | DB05123 | ACC inhibitor; apo C-III inhibitor; CRP inhibitor; CCR2 receptor antagonist; CCR5 receptor antagonist; lipoprotein A inhibitor; PPAR agonist; sulfatase inhibitor | Enhance lipid metabolism; Anti-fibrosis | Failed in clinical trials | Details |
| D150 | Genistein | Chemical drug | DB01645 | NCOA1; NCOA2; NR1I2 | -- | Under clinical trials | Details |
| D154 | Glimepiride | Chemical drug | DB00222 | ABCC8 binder; KCNJ1 inhibitor; KCNJ11 inhibitor; KCNJ11 potassium channel inhibitor | Antidiabetic drug | Under clinical trials | Details |
| D203 | Levothyroxine | Chemical drug | DB00451 | THRA agonist; THRB agonist | Anti-fibrosis | Under clinical trials | Details |
| D207 | Liraglutide | Biological drug | DB06655 | GLP1R activator; GLP1R agonist; GCG receptor antagonist activity | Improve insulin resistance | Under clinical trials | Details |
| D258 | Omega 3 PUFA | Chemical drug | DB11133 | PPARG ligand; PPARA activator | Hypolipidemic drug | Under clinical trials | Details |
| D259 | Omeprazole | Chemical drug | DB00338 | AHR agonist | -- | Under clinical trials | Details |
| D264 | Pantoprazole | Chemical drug | DB00213 | gastric H-K-ATPase inhibitor; ATP4B inhibitor; ATP4A inhibitor | Gastrointestinal drug | Under clinical trials | Details |
| D266 | Pentoxifylline | Chemical drug | DB00806 | ADORA2A antagonist; ADORA1 antagonist; PDE4A inhibitor; PDE3B inhibitor; PDE4B inhibitor; PDE5A inhibitor; PDE8A inhibitor; PDE4C inhibitor; PDE11A inhibitor; PDE7A inhibitor; PDE7B inhibitor; PDE4D inhibitor; PDE3A inhibitor | Anti-inflammatory; Cardiovascular drug | Under clinical trials | Details |
| D267 | Perindopril | Chemical drug | DB00790 | ACE inhibitor | Antihypertensive drug | Under clinical trials | Details |
| D277 | Pitavastatin | Chemical drug | DB08860 | HMGCR inhibitor | Enhance lipid metabolism | Failed in clinical trials | Details |
| D298 | Ranolazine | Chemical drug | DB00243 | -- | -- | Under clinical trials | Details |
| D300 | Resmetirom | Chemical drug | DB12914 | THRB agonist | Anti-fibrosis | Advanced in clinical trials | Details |
| D312 | Rosuvastatin | Chemical drug | DB01098 | HMGCR inhibitor | Enhance lipid metabolism | Under clinical trials | Details |
| D322 | Sebelipase Alfa | Biological drug | DB11563 | -- | Enzyme replacement therapy | Under clinical trials | Details |
| D327 | Semaglutide | Chemical drug | DB13928 | GLP1R agonist | Antidiabetic drug | Under clinical trials | Details |
| D388 | Vitamin E | Supplement | DB00163 | NR1I2; ALOX5; DGKA | Anti-inflammatory | Under clinical trials | Details |
| D476 | Estradiol | Chemical drug | DB00783 | -- | -- | Under clinical trials | Details |
| D527 | EPA/DHA | Supplement | DB11133 | -- | -- | Under clinical trials | Details |
| D541 | Olmesartan | Chemical drug | DB00275 | -- | -- | Under clinical trials | Details |