| Trial ID: | L0853 |
| Source ID: | IRCT2016010411991N3
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| Associated Drug: |
Pioglitazone
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| Title: |
Compare the therapeutic effect of metformin, pioglitazone and vitaminE E in patients with non-alcoholic fatty liver disease
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| Acronym: |
--
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| Status: |
Not Recruiting
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| Study Results: |
No Results Available
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| Results: |
--
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| Conditions: |
non-alcoholic fatty liver disease. <br>Fatty (change of) liver, not elsewhere classified;Fatty (change of) liver, not elsewhere classified
|
| Interventions: |
Intervention 1: Intervention group: metformin2 gr daily,orally for12 weeks. Intervention 2: Intervention group: Pioglitazone30 mg dialy, orally for12 weeks. Intervention 3: Intervention group: vitamin E 800 IU daily, orally for 12 weeks.;Treatment - Drugs
|
| Outcome Measures: |
Severity of fatty liver. Timepoint: before and 12 weeks after the interventions. Method of measurement: according to echogenicity of the liver and its comparison with the adjacent kidney, and also comparison with echogenicity of the spleen, and the view of diaphragm and perivascular region of the intrahepatic vessels.;Serum level of liver function tests (AST, ALT, Alkp). Timepoint: before and 12 weeks after the interventions. Method of measurement: (IU/l) by diagnostic laboratory kits (Pars Azmoon, Iran) and the auto analyzer (Hitachi 902).Body mass index(BMI). Timepoint: before and 12 weeks after the interventions. Method of measurement: (Kg/m2).;Insulin resistance index(HOMA-IR). Timepoint: before and 12 weeks after the interventions. Method of measurement: [fasting glucose (mg/dl) ?? insulin (??U/ml)]/ 405.;Fasting blood sugar. Timepoint: before and 12 weeks after the interventions. Method of measurement: mg/dlby diagnostic laboratory kits (Pars Azmoon, Iran) and the auto analyzer (Hitachi 902).;Serum level of insulin. Timepoint: before and 12 weeks after the interventions. Method of measurement: (??u/ml) by Monobind ELISA kit (Monobind, USA).
|
| Sponsor/Collaborators: |
Vice chancellor for research,Kermanshah University of Medical Sciences
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| Gender: |
All
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| Age: |
18 years75 years
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| Phases: |
Not applicable
|
| Enrollment: |
93
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| Study Type: |
interventional
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| Study Designs: |
Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment.
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| Start Date: |
22/01/2016
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| Completion Date: |
--
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| Results First Posted: |
--
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| Last Update Posted: |
22 February 2018
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| Locations: |
Iran (Islamic Republic of)
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| URL: |
http://en.irct.ir/trial/12159
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