Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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apoptosis1710 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A35241 | 21321532 | Lab Invest | Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice. | 2011 | Details |
| A35325 | 21081801 | J Physiol Pharmacol | The effects of L-tryptophan and melatonin on selected biochemical parameters in patients with steatohepatitis. | 2010 | Details |
| A35496 | 20539006 | Am J Physiol Gastrointest Liver Physiol | Diabetic KK-A(y) mice are highly susceptible to oxidative hepatocellular damage induced by acetaminophen. | 2010 | Details |
| A35531 | 20425484 | Curr Gastroenterol Rep | Nontriglyceride hepatic lipotoxicity: the new paradigm for the pathogenesis of NASH. | 2010 | Details |
| A35539 | 20408954 | Liver Int | Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis. | 2010 | Details |
| A35557 | 20368703 | Lab Invest | Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice. | 2010 | Details |
| A35593 | 20206177 | Gastroenterology | Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice. | 2010 | Details |
| A35650 | 20028348 | Alcohol Clin Exp Res | Moderate alcohol consumption aggravates high-fat diet induced steatohepatitis in rats. | 2009 | Details |
| A35654 | 20009134 | Ann Hepatol | NASH and cryptogenic cirrhosis: a histological analysis. | 2010 | Details |
| A35659 | 19998387 | Hepatology | Major histocompatibility complex class I-related chains A and B (MIC A/B): a novel role in nonalcoholic steatohepatitis. | 2010 | Details |
| A35688 | 19906783 | J Clin Endocrinol Metab | Apoptotic markers indicate nonalcoholic steatohepatitis in polycystic ovary syndrome. | 2009 | Details |
| A35765 | 19748164 | Clin Nutr | Inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats. | 2009 | Details |
| A35805 | 19647752 | Life Sci | Synthetic triglyceride containing an arachidonic acid branch (8A8) prevents lipopolysaccharide-induced liver injury. | 2009 | Details |
| A35822 | 19606393 | Scand J Gastroenterol | Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice. | 2009 | Details |
| A35856 | 19552763 | J Pineal Res | Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats. | 2009 | Details |
| A35887 | 19496180 | Hepatology | Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent. | 2009 | Details |
| A35915 | 19422479 | Liver Int | Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis. | 2009 | Details |
| A35956 | 19333204 | Med Sci Monit | Elevated serum levels of caspase-cleaved cytokeratin 18 (CK18-Asp396) in patients with nonalcoholic steatohepatitis and chronic hepatitis C. | 2009 | Details |
| A36077 | 19053005 | Z Gastroenterol | Adalimumab could suppress the activity of non alcoholic steatohepatitis (NASH). | 2008 | Details |
| A36089 | 19030170 | Hepatology | Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression. | 2008 | Details |
| A36101 | 19004024 | Int J Cancer | Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats. | 2009 | Details |
| A36116 | 18986378 | Alcohol Clin Exp Res | Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model. | 2009 | Details |
| A36118 | 18984468 | Clin Liver Dis | Disease-specific mechanisms of fibrosis: hepatitis C virus and nonalcoholic steatohepatitis. | 2008 | Details |
| A36159 | 18848945 | Gastroenterology | Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice. | 2008 | Details |
| A36180 | 18806094 | J Nutr | Increased apoptosis in high-fat diet-induced nonalcoholic steatohepatitis in rats is associated with c-Jun NH2-terminal kinase activation and elevated proapoptotic Bax. | 2008 | Details |
| A36326 | 18456456 | J Autoimmun | Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study. | 2008 | Details |
| A36341 | 18408102 | Gut | Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis. | 2008 | Details |
| A36376 | 18349116 | Am J Physiol Endocrinol Metab | Partial leptin deficiency favors diet-induced obesity and related metabolic disorders in mice. | 2008 | Details |
| A36465 | 18082745 | Gastroenterology | Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. | 2007 | Details |
| A36469 | 18063353 | Nutr Metab Cardiovasc Dis | Molecular determinants of insulin resistance, cell apoptosis and lipid accumulation in non-alcoholic steatohepatitis. | 2007 | Details |
| A36514 | 17951222 | J Lipid Res | Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes. | 2007 | Details |
| A36516 | 17947452 | Am J Physiol Gastrointest Liver Physiol | A new model for nonalcoholic steatohepatitis in the rat utilizing total enteral nutrition to overfeed a high-polyunsaturated fat diet. | 2007 | Details |
| A36562 | 17825453 | J Hepatol | Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death. | 2007 | Details |
| A36567 | 17729114 | Free Radic Res | Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats. | 2007 | Details |
| A36597 | 17661371 | Hepatology | The effects of 48 weeks of rosiglitazone on hepatocyte mitochondria in human nonalcoholic steatohepatitis. | 2007 | Details |
| A36600 | 17654603 | Hepatology | Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C. | 2007 | Details |
| A36669 | 17487265 | Can J Physiol Pharmacol | Combining ursodeoxycholic acid or its NO-releasing derivative NCX-1000 with lipophilic antioxidants better protects mouse hepatocytes against amiodarone toxicity. | 2007 | Details |
| A36706 | 17415659 | Dig Dis Sci | Enhanced sensitivity to CD95-induced apoptosis in ob/ob mice. | 2007 | Details |
| A36760 | 17322381 | Am J Pathol | Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis. | 2007 | Details |
| A36775 | 17292824 | Cancer Cell | Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. | 2007 | Details |
| A36799 | 17244458 | Zhonghua Gan Zang Bing Za Zhi | [The role of apoptosis and the related genes in non-alcoholic steatohepatitis]. | 2007 | Details |
| A36925 | 16936261 | Am J Pathol | A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury. | 2006 | Details |
| A37019 | 16706830 | J Gastroenterol Hepatol | Rodent nutritional model of steatohepatitis: effects of endotoxin (lipopolysaccharide) and tumor necrosis factor alpha deficiency. | 2006 | Details |
| A37112 | 16447275 | Hepatology | Reversal of hepatic fibrosis -- fact or fantasy? | 2006 | Details |
| A37130 | 16406828 | Mitochondrion | Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. | 2006 | Details |
| A37164 | 16357615 | Eur J Gastroenterol Hepatol | Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis. | 2006 | Details |
| A37222 | 16223772 | Blood | Interaction between integrin alpha9beta1 and vascular cell adhesion molecule-1 (VCAM-1) inhibits neutrophil apoptosis. | 2005 | Details |
| A37248 | 16174657 | Gut | Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice. | 2005 | Details |
| A37521 | 15495250 | J Pathol | The keratin cytoskeleton in liver diseases. | 2004 | Details |
| A37579 | 15330907 | Am J Gastroenterol | Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. | 2004 | Details |
| A37635 | 15223984 | Diabetes Metab | The ins and outs of mitochondrial dysfunction in NASH. | 2004 | Details |
| A37757 | 14734794 | Exp Biol Med (Maywood) | Sex differences in choline-deficient diet-induced steatohepatitis in mice. | 2004 | Details |
| A37764 | 14720457 | Curr Gastroenterol Rep | Advances in alcoholic liver disease. | 2004 | Details |
| A37831 | 14527080 | Curr Mol Med | Mechanisms of liver injury: an overview. | 2003 | Details |
| A37875 | 12891546 | Gastroenterology | Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. | 2003 | Details |
| A38236 | 11812920 | Toxicol Sci | Mechanisms of hepatotoxicity. | 2002 | Details |
| A38249 | 11766638 | Pathologe | [Alcoholic and nonalcoholic steatohepatitis. Histopathologic and pathogenetic considerations]. | 2001 | Details |
| A38378 | 11395389 | Am J Pathol | Murine gammaherpesvirus-68 infection causes multi-organ fibrosis and alters leukocyte trafficking in interferon-gamma receptor knockout mice. | 2001 | Details |
| A38744 | 10416754 | Surv Ophthalmol | Neuroprotection in relation to retinal ischemia and relevance to glaucoma. | 1999 | Details |
| A42297 | 34935193 | Fundam Clin Pharmacol | Hepatoprotective and therapeutic effects of resveratrol: A focus on anti-inflammatory and antioxidative activities. | 2022 | Details |
| A42305 | 34917919 | Metabol Open | DRAK2-SRSF6-regulated RNA alternative splicing is a promising therapeutic target in NAFLD/NASH. | 2021 | Details |
| A42353 | 34779503 | Mol Med Rep | Efferocytosis in multisystem diseases (Review). | 2021 | Details |
| A42359 | 34767670 | Biofactors | Vitamin D3 enhances the effects of omega-3 oils against metabolic dysfunction-associated fatty liver disease in rat. | 2021 | Details |
| A42403 | 34630116 | Front Pharmacol | An Integrative Pharmacology Based Analysis of Refined Liuweiwuling Against Liver Injury: A Novel Component Combination and Hepaprotective Mechanism. | 2021 | Details |
| A42432 | 34540892 | Front Mol Biosci | Therapeutic Effects of an Inhibitor of Thioredoxin Reductase on Liver Fibrosis by Inhibiting the Transforming Growth Factor-β1/Smads Pathway. | 2021 | Details |
| A42487 | 34402268 | Zhongguo Zhong Yao Za Zhi | [Efficacy and mechanism of new resource medicinal materia Moringa oleifera leaves against hyperlipidemia]. | 2021 | Details |
| A42540 | 34202146 | Biomolecules | Molecular Initiating Events Associated with Drug-Induced Liver Malignant Tumors: An Integrated Study of the FDA Adverse Event Reporting System and Toxicity Predictions. | 2021 | Details |
| A42735 | 33604316 | Can J Gastroenterol Hepatol | A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma. | 2021 | Details |
| A42818 | 33354565 | Biomed Res Int | Sex Difference of Ribosome in Stroke-Induced Peripheral Immunosuppression by Integrated Bioinformatics Analysis. | 2020 | Details |
| A42907 | 33142445 | Poult Sci | Maintaining intestinal structural integrity is a potential protective mechanism against inflammation in goose fatty liver. | 2020 | Details |
| A42976 | 32906011 | Pathol Res Pract | Correlation between M30 immunochemistry and histological activity in steatohepatitis: One piece of a complex puzzle. | 2020 | Details |
| A43053 | 32693115 | J Ethnopharmacol | A review of the processed Polygonum multiflorum (Thunb.) for hepatoprotection: Clinical use, pharmacology and toxicology. | 2020 | Details |
| A43060 | 32668973 | Am J Chin Med | Gastrodin Pretreatment Protects Liver Against Ischemia-Reperfusion Injury via Activation of the Nrf2/HO-1 Pathway. | 2020 | Details |
| A43084 | 32609746 | PLoS One | Correction: Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice. | 2020 | Details |
| A43107 | 32553811 | Eur J Pharmacol | The effect of emodin on liver disease -- comprehensive advances in molecular mechanisms. | 2020 | Details |
| A43157 | 32410996 | Front Pharmacol | Paeoniflorin, a Natural Product With Multiple Targets in Liver Diseases-A Mini Review. | 2020 | Details |
| A43189 | 32342535 | Hepatology | The Metabolic Sensor Adenosine Monophosphate-Activated Protein Kinase Regulates Apoptosis in Nonalcoholic Steatohepatitis. | 2020 | Details |
| A43230 | 32229664 | J Basic Clin Physiol Pharmacol | Altered composition of high-lipid diet may generate reactive oxygen species by disturbing the balance of antioxidant and free radicals. | 2020 | Details |
| A43277 | 32086945 | Hepatology | Elevated Fructose and Uric Acid Through Aldose Reductase Contribute to Experimental and Human Alcoholic Liver Disease. | 2020 | Details |
| A43537 | 31475778 | J Cell Mol Med | Protective role of melatonin in early-stage and end-stage liver cirrhosis. | 2019 | Details |
| A43623 | 31264285 | J Cell Biochem | Effect of oleic acid on induction of steatosis and cytotoxicity in BRL 3A cells. | 2019 | Details |
| A43660 | 31162673 | Alcohol Clin Exp Res | Chalcone Derivative L6H21 Reduces EtOH + LPS-Induced Liver Injury Through Inhibition of NLRP3 Inflammasome Activation. | 2019 | Details |
| A43749 | 30968034 | World J Clin Cases | Effects of apoptosis on liver aging. | 2019 | Details |
| A43762 | 30945509 | Zhen Ci Yan Jiu | [Progress of researches on mechanisms of acupuncture therapy for insulin resistance]. | 2019 | Details |
| A43766 | 30920299 | Am J Physiol Gastrointest Liver Physiol | Translational and transcriptional responses in human primary hepatocytes under hypoxia. | 2019 | Details |
| A43821 | 30791762 | Expert Rev Gastroenterol Hepatol | Apoptosis signal-regulating kinase-1 as a therapeutic target in nonalcoholic fatty liver disease. | 2019 | Details |
| A43838 | 30741841 | J Clin Gastroenterol | Thirty Years of Lactobacillus rhamnosus GG: A Review. | 2019 | Details |
| A43880 | 30610616 | Arch Pharm Res | Role of non-coding RNAs in liver disease progression to hepatocellular carcinoma. | 2019 | Details |
| A43946 | 30379115 | Rejuvenation Res | Rosmarinic Acid Ameliorates H2O2-Induced Oxidative Stress in L02 Cells Through MAPK and Nrf2 Pathways. | 2018 | Details |
| A44069 | 29967757 | PeerJ | Huperzine A attenuates nonalcoholic fatty liver disease by regulating hepatocyte senescence and apoptosis: an in vitro study. | 2018 | Details |
| A44085 | 29867233 | Nat Med | Impact of neutralizing antibodies against AAV is a key consideration in gene transfer to nonhuman primates. | 2018 | Details |
| A44096 | 29767698 | Adv Nutr | Mechanisms by Which Dietary Fatty Acids Regulate Mitochondrial Structure-Function in Health and Disease. | 2018 | Details |
| A44101 | 29747160 | Neoplasia | Targeting Liver Cancer and Associated Pathologies in Mice with a Mitochondrial VDAC1-Based Peptide. | 2018 | Details |
| A44205 | 29408544 | J Hepatol | Pyroptosis: An inflammatory link between NAFLD and NASH with potential therapeutic implications. | 2018 | Details |
| A44246 | 29254277 | Oncotarget | Apoptosis in the aging liver. | 2017 | Details |
| A44364 | 28834692 | J Mol Biol | Soluble Extracellular Domain of Death Receptor 5 Inhibits TRAIL-Induced Apoptosis by Disrupting Receptor-Receptor Interactions. | 2017 | Details |
| A44521 | 28377639 | Nat Rev Gastroenterol Hepatol | NASH: Novel therapeutic strategies targeting ASK1 in NASH. | 2017 | Details |
| A44528 | 28356593 | Nat Rev Drug Discov | Liver disease: Conscious uncoupling in NASH. | 2017 | Details |
| A44615 | 27942586 | JCI Insight | IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans. | 2016 | Details |
| A44678 | 27435327 | Dig Dis Sci | Targeting Hepatic Fibrosis in Autoimmune Hepatitis. | 2016 | Details |