Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Fatty acid synthase594 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A14027 | 29629027 | Nutr Res Pract | Ethanol extract of Allium fistulosum inhibits development of non-alcoholic fatty liver disease. | 2018 | Details |
| A14063 | 29604329 | Mol Cell Endocrinol | MiR-451a attenuates free fatty acids-mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene. | 2018 | Details |
| A14116 | 29575055 | J Cell Biochem | MicroRNA-190b regulates lipid metabolism and insulin sensitivity by targeting IGF-1 and ADAMTS9 in non-alcoholic fatty liver disease. | 2018 | Details |
| A14172 | 29552625 | Cell Mol Gastroenterol Hepatol | Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2). | 2017 | Details |
| A14176 | 29550812 | Cell Physiol Biochem | Lack of ClC-2 Alleviates High Fat Diet-Induced Insulin Resistance and Non-Alcoholic Fatty Liver Disease. | 2018 | Details |
| A14187 | 29542003 | J Nat Med | Scutellaria baicalensis regulates FFA metabolism to ameliorate NAFLD through the AMPK-mediated SREBP signaling pathway. | 2018 | Details |
| A14234 | 29512720 | Mol Med Rep | Alogliptin alleviates hepatic steatosis in a mouse model of nonalcoholic fatty liver disease by promoting CPT1a expression via Thr172 phosphorylation of AMPKα in the liver. | 2018 | Details |
| A14395 | 29428667 | Biomed Pharmacother | Silybum marianum oil attenuates hepatic steatosis and oxidative stress in high fat diet-fed mice. | 2018 | Details |
| A14404 | 29426937 | Nat Commun | Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation. | 2018 | Details |
| A14412 | 29419789 | Nutrients | Aged Oolong Tea Reduces High-Fat Diet-Induced Fat Accumulation and Dyslipidemia by Regulating the AMPK/ACC Signaling Pathway. | 2018 | Details |
| A14751 | 29255346 | Drug Des Devel Ther | Hepatoprotective effect of calculus bovis sativus on nonalcoholic fatty liver disease in mice by inhibiting oxidative stress and apoptosis of hepatocytes. | 2017 | Details |
| A14764 | 29249184 | Hum Exp Toxicol | Caffeine affects HFD-induced hepatic steatosis by multifactorial intervention. | 2017 | Details |
| A14864 | 29201040 | PPAR Res | Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice. | 2017 | Details |
| A14866 | 29199584 | Int J Med Mushrooms | Anti-Inflammation and Lipogenic Inhibition of Taiwanofungus salmonea Mycelium and Grifola frondosa Fruiting Body. | 2017 | Details |
| A14920 | 29174039 | Biomed Pharmacother | Lavatera critica, a green leafy vegetable, controls high fat diet induced hepatic lipid accumulation and oxidative stress through the regulation of lipogenesis and lipolysis genes. | 2017 | Details |
| A14957 | 29156529 | Biomed Pharmacother | Alpinetin improved high fat diet-induced non-alcoholic fatty liver disease (NAFLD) through improving oxidative stress, inflammatory response and lipid metabolism. | 2017 | Details |
| A15114 | 29088779 | Oncotarget | The additive effects of the TM6SF2 E167K and PNPLA3 I148M polymorphisms on lipid metabolism. | 2017 | Details |
| A15293 | 28982243 | J Agric Food Chem | Solanum nigrum Polyphenol Extracts Inhibit Hepatic Inflammation, Oxidative Stress, and Lipogenesis in High-Fat-Diet-Treated Mice. | 2017 | Details |
| A15344 | 28955124 | J Clin Biochem Nutr | Effects of soy isoflavone on hepatic steatosis in high fat-induced rats. | 2017 | Details |
| A15587 | 28827398 | Mol Syst Biol | Network analyses identify liver-specific targets for treating liver diseases. | 2017 | Details |
| A15893 | 28667176 | J Mol Endocrinol | miR-212-5p suppresses lipid accumulation by targeting FAS and SCD1. | 2017 | Details |
| A16073 | 28585211 | Adv Exp Med Biol | Non-Alcoholic Fatty Liver Disease. | 2017 | Details |
| A16086 | 28577569 | Lipids Health Dis | Overexpression of apolipoprotein A-I alleviates endoplasmic reticulum stress in hepatocytes. | 2017 | Details |
| A16146 | 28539716 | Pharmacogn Mag | Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-β-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell. | 2017 | Details |
| A16161 | 28529818 | J Diabetes Metab | High protein/fish oil diet prevents hepatic steatosis in NONcNZO10 mice; association with diet/genetics-regulated micro-RNAs. | 2016 | Details |
| A16182 | 28514835 | Biomed Pharmacother | Genistein has beneficial effects on hepatic steatosis in high fat-high sucrose diet-treated rats. | 2017 | Details |
| A16337 | 28449683 | Lipids Health Dis | Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway. | 2017 | Details |
| A16361 | 28437865 | Hepatology | A novel role of astrocyte elevated gene-1 (AEG-1) in regulating nonalcoholic steatohepatitis (NASH). | 2017 | Details |
| A16527 | 28335388 | Nutrients | A Combination of Flaxseed Oil and Astaxanthin Improves Hepatic Lipid Accumulation and Reduces Oxidative Stress in High Fat-Diet Fed Rats. | 2017 | Details |
| A16562 | 28315901 | Med Sci Monit | The Effect of Sitagliptin on Lipid Metabolism of Fatty Liver Mice and Related Mechanisms. | 2017 | Details |
| A16608 | 28285648 | Metabolism | Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice. | 2017 | Details |
| A16669 | 28254666 | Biomed Pharmacother | Kukoamine A attenuates insulin resistance and fatty liver through downregulation of Srebp-1c. | 2017 | Details |
| A16696 | 28239368 | Front Endocrinol (Lausanne) | Connection of Nicotine to Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease: Cellular and Mechanistic Insights. | 2017 | Details |
| A16697 | 30263537 | Food Sci Biotechnol | Inhibitory effect of esculetin on free-fatty-acid-induced lipid accumulation in human HepG2 cells through activation of AMP-activated protein kinase. | 2017 | Details |
| A16707 | 28231800 | Lipids Health Dis | Dietary intervention, but not losartan, completely reverses non-alcoholic steatohepatitis in obese and insulin resistant mice. | 2017 | Details |
| A16720 | 28223710 | Sci Rep | High-Intensity Aerobic Exercise Improves Both Hepatic Fat Content and Stiffness in Sedentary Obese Men with Nonalcoholic Fatty Liver Disease. | 2017 | Details |
| A16776 | 28184213 | Front Endocrinol (Lausanne) | Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease. | 2017 | Details |
| A16807 | 28161992 | Am J Chin Med | Antrodia cinnamomea Prevents Obesity, Dyslipidemia, and the Derived Fatty Liver via Regulating AMPK and SREBP Signaling. | 2017 | Details |
| A16825 | 28146130 | Nutrients | Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD). | 2017 | Details |
| A16830 | 28142230 | Korean J Intern Med | Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent pathways in type 2 diabetic OLETF rats. | 2017 | Details |
| A16872 | 28116779 | Mol Nutr Food Res | Long-term dietary supplementation with low-dose nobiletin ameliorates hepatic steatosis, insulin resistance, and inflammation without altering fat mass in diet-induced obesity. | 2017 | Details |
| A16930 | 28088781 | Oncotarget | MiR-30c-5p ameliorates hepatic steatosis in leptin receptor-deficient (db/db) mice via down-regulating FASN. | 2017 | Details |
| A16944 | 28081181 | PLoS One | Aronia melanocarpa Extract Ameliorates Hepatic Lipid Metabolism through PPARγ2 Downregulation. | 2017 | Details |
| A17038 | 28036028 | Nutrients | Application of an In Vivo Hepatic Triacylglycerol Production Method in the Setting of a High-Fat Diet in Mice. | 2016 | Details |
| A17051 | 28027934 | Biochem Biophys Res Commun | Histone modifications in FASN modulated by sterol regulatory element-binding protein 1c and carbohydrate responsive-element binding protein under insulin stimulation are related to NAFLD. | 2016 | Details |
| A17078 | 28003715 | J Clin Exp Hepatol | High-Fructose Intake Impairs the Hepatic Hypolipidemic Effects of a High-Fat Fish-Oil Diet in C57BL/6 Mice. | 2016 | Details |
| A17225 | 27903831 | J Nutr | Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-Induced, Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A17251 | 27889747 | Cell Physiol Biochem | Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells. | 2016 | Details |
| A17316 | 27852305 | Lipids Health Dis | Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice. | 2016 | Details |
| A17352 | 27828718 | J Med Food | 5,7-Dimethoxyflavone Attenuates Obesity by Inhibiting Adipogenesis in 3T3-L1 Adipocytes and High-Fat Diet-Induced Obese C57BL/6J Mice. | 2016 | Details |
| A17362 | 27824080 | Sci Rep | Lycium barbarum polysaccharide attenuates high-fat diet-induced hepatic steatosis by up-regulating SIRT1 expression and deacetylase activity. | 2016 | Details |
| A17411 | 27796685 | Mol Cell Biochem | Genes involved in the establishment of hepatic steatosis in Muscovy, Pekin and mule ducks. | 2016 | Details |
| A17431 | 27769711 | Chem Biol Interact | Esculetin prevents non-alcoholic fatty liver in diabetic mice fed high-fat diet. | 2016 | Details |
| A17442 | 27784782 | J Biol Chem | Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) α. | 2016 | Details |
| A17474 | 27732911 | J Nutr Biochem | Preventive effects of dietary walnuts on high-fat-induced hepatic fat accumulation, oxidative stress and apoptosis in mice. | 2016 | Details |
| A17481 | 27490779 | Biomed Pharmacother | Swertiamarin ameliorates oleic acid induced lipid accumulation and oxidative stress by attenuating gluconeogenesis and lipogenesis in hepatic steatosis. | 2016 | Details |
| A17488 | 27768909 | J Nutr Biochem | High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation. | 2016 | Details |
| A17492 | 27765368 | Phytomedicine | The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats. | 2016 | Details |
| A17512 | 27762456 | Phytother Res | Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid-Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPARα/CPT-1 Pathway and in Acute Hyperlipidemia Mouse Model. | 2016 | Details |
| A17631 | 27701891 | Expert Opin Drug Discov | Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors. | 2016 | Details |
| A17662 | 27680310 | Biochem Biophys Res Commun | Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease. | 2016 | Details |
| A17953 | 27456850 | BMC Complement Altern Med | Anti-lipoapoptotic effects of Alisma orientalis extract on non-esterified fatty acid-induced HepG2 cells. | 2016 | Details |
| A17971 | 27445343 | Am J Physiol Gastrointest Liver Physiol | A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats. | 2016 | Details |
| A18030 | 27404046 | J Gastroenterol Hepatol | Loss of lipopolysaccharide-binding protein attenuates the development of diet-induced non-alcoholic fatty liver disease in mice. | 2017 | Details |
| A18083 | 27357269 | Mol Med Rep | Impact of activating transcription factor 4 signaling on lipogenesis in HepG2 cells. | 2016 | Details |
| A18105 | 27349145 | Eur J Pharmacol | Effects of the new thiazolidine derivative LPSF/GQ-02 on hepatic lipid metabolism pathways in non-alcoholic fatty liver disease (NAFLD). | 2016 | Details |
| A18118 | 27343380 | Eur J Pharmacol | (S)YS-51, a novel isoquinoline alkaloid, attenuates obesity-associated non-alcoholic fatty liver disease in mice by suppressing lipogenesis, inflammation and coagulation. | 2016 | Details |
| A18204 | 27288055 | J Endocrinol | Metformin increases hepatic leptin receptor and decreases steatosis in mice. | 2016 | Details |
| A18235 | 27266339 | J Med Food | Hepatoprotective Effects of Soybean Embryo by Enhancing Adiponectin-Mediated AMP-Activated Protein Kinase α Pathway in High-Fat and High-Cholesterol Diet-Induced Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A18285 | 29879345 | Yao Xue Xue Bao | [Investigating the effects of compound WS090152 on non-alcoholic fatty liver in mice]. | 2016 | Details |
| A18295 | 27234712 | Mol Nutr Food Res | β-Caryophyllene attenuates palmitate-induced lipid accumulation through AMPK signaling by activating CB2 receptor in human HepG2 hepatocytes. | 2016 | Details |
| A18296 | 27233614 | Biochem Biophys Res Commun | Spontaneous nonalcoholic fatty liver disease and ER stress in Sidt2 deficiency mice. | 2016 | Details |
| A18357 | 27184670 | BMC Complement Altern Med | Rhodiola crenulata extract regulates hepatic glycogen and lipid metabolism via activation of the AMPK pathway. | 2016 | Details |
| A18372 | 27176782 | Mol Med Rep | Treatment with estrogen protects against ovariectomy-induced hepatic steatosis by increasing AQP7 expression. | 2016 | Details |
| A18391 | 27166182 | Oncotarget | Reduced miR-200b and miR-200c expression contributes to abnormal hepatic lipid accumulation by stimulating JUN expression and activating the transcription of srebp1. | 2016 | Details |
| A18491 | 27095767 | Zhonghua Gan Zang Bing Za Zhi | [Effect of chitooligosaccharide on hepatic triglyceride metabolism and related mechanisms]. | 2016 | Details |
| A18512 | 27081834 | Mol Med Rep | Artemisia capillaris formula inhibits hepatic steatosis via an miR‑122‑induced decrease in fatty acid synthase expression in vivo and in vitro. | 2016 | Details |
| A18746 | 26973390 | World J Gastroenterol | Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression. | 2016 | Details |
| A18795 | 26936230 | Sci Rep | Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue Inflammation in Mice with Diet-induced Obesity. | 2016 | Details |
| A18804 | 26932533 | Int J Food Sci Nutr | Medium-chain fatty acid reduces lipid accumulation by regulating expression of lipid-sensing genes in human liver cells with steatosis. | 2016 | Details |
| A18856 | 26900108 | J Agric Food Chem | Ginger Essential Oil Ameliorates Hepatic Injury and Lipid Accumulation in High Fat Diet-Induced Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A18870 | 26892709 | Exp Biol Med (Maywood) | De novo lipogenesis is suppressed during fasting but upregulated at population decline in cyclic voles. | 2016 | Details |
| A18921 | 26869449 | Biochim Biophys Acta | Lipid accumulation stimulates the cap-independent translation of SREBP-1a mRNA by promoting hnRNP A1 binding to its 5'-UTR in a cellular model of hepatic steatosis. | 2016 | Details |
| A18972 | 26842974 | J Chin Med Assoc | Lipid-lowering, hepatoprotective, and atheroprotective effects of the mixture Hong-Qu and gypenosides in hyperlipidemia with NAFLD rats. | 2016 | Details |
| A19001 | 26825546 | Eur J Pharmacol | Effects of combined PPAR-γ and PPAR-α agonist therapy on fructose induced NASH in rats: Modulation of gene expression. | 2016 | Details |
| A19045 | 26805874 | Nutrients | Docosahexaenoic Acid Ameliorates Fructose-Induced Hepatic Steatosis Involving ER Stress Response in Primary Mouse Hepatocytes. | 2016 | Details |
| A19085 | 26773785 | Nutr Res | Adzuki bean ameliorates hepatic lipogenesis and proinflammatory mediator expression in mice fed a high-cholesterol and high-fat diet to induce nonalcoholic fatty liver disease. | 2015 | Details |
| A19086 | 26773781 | Nutr Res | Chokeberry attenuates the expression of genes related to de novo lipogenesis in the hepatocytes of mice with nonalcoholic fatty liver disease. | 2015 | Details |
| A19213 | 26698881 | J Biol Chem | The Hepatitis C Virus-induced NLRP3 Inflammasome Activates the Sterol Regulatory Element-binding Protein (SREBP) and Regulates Lipid Metabolism. | 2015 | Details |
| A19235 | 26681923 | Int J Biol Sci | A20 Attenuates FFAs-induced Lipid Accumulation in Nonalcoholic Steatohepatitis. | 2015 | Details |
| A19249 | 26674248 | BBA Clin | Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy. | 2015 | Details |
| A19390 | 26593707 | Eur J Pharmacol | Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats. | 2015 | Details |
| A19562 | 26485433 | PLoS One | 3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats. | 2015 | Details |
| A19601 | 26462866 | Diabetes Obes Metab | Retinoic acid receptor β2 agonists restore glycaemic control in diabetes and reduce steatosis. | 2015 | Details |
| A19649 | 26438035 | BMC Complement Altern Med | Extracts from Aralia elata (Miq) Seem alleviate hepatosteatosis via improving hepatic insulin sensitivity. | 2015 | Details |
| A19717 | 26397061 | Mol Med Rep | Therapeutic effects of the dipeptidyl peptidase-IV inhibitor, sitagliptin, on non-alcoholic steatohepatitis in FLS-ob/ob male mice. | 2015 | Details |
| A19724 | 26394261 | Appl Physiol Nutr Metab | Combining metformin therapy with caloric restriction for the management of type 2 diabetes and nonalcoholic fatty liver disease in obese rats. | 2015 | Details |
| A19827 | 26322888 | PLoS One | Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A19859 | 26300958 | Chin Med | Crude triterpenoid saponins from Ilex latifolia (Da Ye Dong Qing) ameliorate lipid accumulation by inhibiting SREBP expression via activation of AMPK in a non-alcoholic fatty liver disease model. | 2015 | Details |
| A19910 | 26272872 | J Hepatol | Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice. | 2015 | Details |