Bioactive Compound Details
| Compound ID: | B105866 |
| Source ID: | CHEMBL193 |
| Source Type: | Small molecule |
| Compound Name: | NIFEDIPINE |
| Synonyms: | ADALAT A.R.|ADALAT CC|ADALAT IC|ADALAT LA 20|ADALAT LA 30|ADALAT LA 60|ADALAT RET|ADALATE LP|ADANIF XL|ADIPINE MR 10|ADIPINE MR 20|ADIPINE XL|AFEDITAB CR|ANGIOPINE 10|ANGIOPINE 40 LA|ANGIOPINE 5|ANGIOPINE MR 10|ANGIOPINE MR 20|Adalat|BAY A 1040|BAY-A-1040|CALANIF|CALCHAN MR 10|CALCHAN MR 20|CALCILAT|CARDILATE MR|CORACTEN|CORACTEN SR|CORACTEN XL|CORODAY MR|FORTIPINE LA40|GENALAT 10 RET|GENALAT 20 RET|HYPOLAR RET 10|HYPOLAR RET 20|HYPOLAR XL 30|KENTIPINE|KENTIPINE MR 10|KENTIPINE MR 20|NEOZIPINE XL|NIFE-WOLFF|NIFEDIPINE|NIFEDIPINE HYDROCHLORIDE|NIFEDIPINE SLOW RELEASE|NIFEDIPINUM|NIFEDIPRESS MR 10|NIFEDIPRESS MR 20|NIFEDOTARD 20 MR|NIFELEASE|NIFENSAR XL|NIFOPRESS MR|NIFOPRESS RET|NIMODREL MR 10|NIMODREL MR 20|NIMODREL XL|NIVATEN RET|NSC-757242|PROCARDIA XL|Procardia|SLOFEDIPINE XL 30|SLOFEDIPINE XL 60|TENSIPINE MR 10|TENSIPINE MR 20|UNIPINE XL|VALNI 20 RET|VALNI XL|VASAD |
| Molecular Formula: | C17H18N2O6 |
| SMILES: | COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T07 | Bile acid receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |
| T17 | Farnesoid X-activated receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |
| T04 | Peroxisome proliferator-activated receptor delta | PPARD | agonist | Nuclear hormone receptor | Q03181 | PPARD_HUMAN | Details |
| T05 | Peroxisome proliferator-activated receptor gamma | PPARG | agonist | Nuclear hormone receptor | P37231 | PPARG_HUMAN | Details |
| T08 | Tumor necrosis factor | TNF | inhibitor | Cytokine | P01375 | TNFA_HUMAN | Details |
| T45 | Arachidonate 12-lipoxygenase | ALOX12 | inhibitor | Enzyme | P18054 | LOX12_HUMAN | Details |