Bioactive Compound Details
| Compound ID: | B132635 |
| Source ID: | CHEMBL384467 |
| Source Type: | Small molecule |
| Compound Name: | DEXAMETHASONE |
| Synonyms: | AEROSEB-DEX|DECADERM|DECADRON-75|DECASPRAY|DEXACORTISYL|DEXAFREE|DEXAMETHASONE|DEXAMETHASONE INTENSOL|DEXAMETHASONE METASULFOBENZOATE SODIUM|DEXAMETHASONE PALMITATE|DEXAMETHASONE VALERATE|DEXONE 0.5|DEXONE 0.75|DEXONE 1.5|DEXONE 4|DEXSOL|DEXTENZA|DEXYCU|DEXYCU KIT|DROPODEX|Dalalone|Decadron|Decadron-LA|Dexacen-4|Dexacort|Dexair|Dexamethasone|Dexone|FLUORMETHYLPREDNISOLONE|GPPE EAR SPY|HEMADY|Hexadrol|ISV-305|Kortico Injection|MARTAPAN|MAXITROL|Maxidex|Mymethasone|NSC-34521|Neodecadron|ORADEXON|OTO-104|OTOMIZE|OZURDEX|SOFRADEX|SPERSADEX COMP|TOBRADEX |
| Molecular Formula: | C22H29FO5 |
| SMILES: | C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T07 | Bile acid receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |
| T17 | Farnesoid X-activated receptor | NR1H4 | agonist | Nuclear hormone receptor | Q96RI1 | NR1H4_HUMAN | Details |
| T40 | N-formyl peptide receptor 2 | FPR2 | inhibitor | Enzyme | P25090 | FPR2_HUMAN | Details |
| T04 | Peroxisome proliferator-activated receptor delta | PPARD | agonist | Nuclear hormone receptor | Q03181 | PPARD_HUMAN | Details |
| T08 | Tumor necrosis factor | TNF | inhibitor | Cytokine | P01375 | TNFA_HUMAN | Details |