Investigational Drugs
Investigational drugs for NAFLD are derived from global clinical trials with the latest progress, and detailed drug properties are extracted from DrugBank and PubChem. For each drug, related therapeutic strategies, targets, and clinical trials in NAFLDkb are presented with knowledge graphs.
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fibrosis45 records.
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D005 | Aldafermin | Biological drug | DB16086 | FGF19 analog | Anti-fibrosis | Under clinical trials | Details |
| D008 | Alpha-tocopherol | Chemical drug | DB00163 | NR1I2; ALOX5; DGKA | -- | Under clinical trials | Details |
| D028 | Belapectin | Chemical drug | DB15125 | Gelactin-3 inhibitor; LGALS3 inhibitor | Anti-fibrosis | Failed in clinical trials | Details |
| D045 | BLD-0409 | Miscellany | -- | ENPP2 inhibitor; ATX inhibitor | Anti-fibrosis | Under clinical trials | Details |
| D046 | Pegbelfermin | Biological drug | DB15365 | FGF21 analog | Improve insulin resistance; Enhance lipid metabolism; Anti-fibrosis | Under clinical trials | Details |
| D068 | Cenicriviroc | Chemical drug | DB11758 | CCR2 inhibitor; CCR5 inhibitor | Anti-fibrosis | Failed in clinical trials | Details |
| D122 | Empagliflozin | Chemical drug | DB09038 | SLC5A2 inhibitor; SGLT-2 inhibitor | Improve insulin resistance | Under clinical trials | Details |
| D123 | Emricasan | Chemical drug | DB05408 | caspase inhibitor | Anti-inflammatory | Failed in clinical trials | Details |
| D134 | Fenretinide | Chemical drug | DB05076 | RARB agonist; RARG agonist | Anti-fibrosis | Under clinical trials | Details |
| D136 | Firsocostat | Chemical drug | DB16166 | ACC inhibitor | Enhance lipid metabolism | Under clinical trials | Details |
| D148 | GB1211 | Chemical drug | -- | Gelactin-3 inhibitor | Anti-fibrosis | Under clinical trials | Details |
| D149 | Gemcabene | Chemical drug | DB05123 | ACC inhibitor; apo C-III inhibitor; CRP inhibitor; CCR2 receptor antagonist; CCR5 receptor antagonist; lipoprotein A inhibitor; PPAR agonist; sulfatase inhibitor | Enhance lipid metabolism; Anti-fibrosis | Failed in clinical trials | Details |
| D187 | Ipragliflozin | Chemical drug | DB11698 | SGLT2 inhibitor | Improve insulin resistance | Under clinical trials | Details |
| D200 | Lanifibranor | Chemical drug | DB14801 | PPARD agonist; PPARA agonist; PPARG agonist | Dermatological drug | Advanced in clinical trials | Details |
| D203 | Levothyroxine | Chemical drug | DB00451 | THRA agonist; THRB agonist | Anti-fibrosis | Under clinical trials | Details |
| D209 | Losartan | Chemical drug | DB00678 | AGTR1 antagonist&binder | Anti-fibrosis | Under clinical trials | Details |
| D216 | Maraviroc | Chemical drug | DB04835 | CCR5 antagonist; CCR5 binder | Anti-fibrosis | Under clinical trials | Details |
| D229 | MitoQ | Chemical drug | DB05063 | -- | Antiparkinsonian drug | Under clinical trials | Details |
| D231 | MN-001 | Chemical drug | DB12435 | -- | -- | Under clinical trials | Details |
| D239 | Niacin | Supplement | DB00627 | NNMT binder | Hypolipidemic drug | Under clinical trials | Details |
| D240 | Nicotinamide | Chemical drug | DB02701 | PARP inhibitor | Metabolic disorder drug | Under clinical trials | Details |
| D248 | Obeticholic Acid | Chemical drug | DB05990 | NR1H4 activator; NR1H4 agonist; FXR agonist | Enhance lipid metabolism | Approval rejected | Details |
| D250 | Odevixibat | Chemical drug | DB16261 | SLC10A2 inhibitor; ASBT inhibitor | -- | Under clinical trials | Details |
| D256 | Oltipraz | Chemical drug | DB12539 | -- | Anticancer agent; antiviral | Under clinical trials | Details |
| D263 | Pancrelipase | Biological drug | DB00085 | -- | -- | Under clinical trials | Details |
| D266 | Pentoxifylline | Chemical drug | DB00806 | ADORA2A antagonist; ADORA1 antagonist; PDE4A inhibitor; PDE3B inhibitor; PDE4B inhibitor; PDE5A inhibitor; PDE8A inhibitor; PDE4C inhibitor; PDE11A inhibitor; PDE7A inhibitor; PDE7B inhibitor; PDE4D inhibitor; PDE3A inhibitor | Anti-inflammatory; Cardiovascular drug | Under clinical trials | Details |
| D283 | Proanthocyanidin | Chemical drug | DB04941 | CFTR antagonist | -- | Under clinical trials | Details |
| D300 | Resmetirom | Chemical drug | DB12914 | THRB agonist | Anti-fibrosis | Advanced in clinical trials | Details |
| D326 | Selonsertib | Chemical drug | DB14916 | MAP3K5 inhibitor; ASK1 inhibitor | Anti-oxidative stress; Anticancer agent | Failed in clinical trials | Details |
| D327 | Semaglutide | Chemical drug | DB13928 | GLP1R agonist | Antidiabetic drug | Under clinical trials | Details |
| D337 | Simtuzumab | Biological drug | DB12152 | LOXL2; antibody | Anti-fibrosis; Anticancer agent; Immunomodulator; | Failed in clinical trials | Details |
| D352 | Sublimated mares milk | Supplement | -- | -- | -- | Under clinical trials | Details |
| D388 | Vitamin E | Supplement | DB00163 | NR1I2; ALOX5; DGKA | Anti-inflammatory | Under clinical trials | Details |
| D390 | VK-2809 | Chemical drug | DB15137 | THR agonist | Anti-fibrosis | Under clinical trials | Details |
| D592 | Ncst ASO | Miscellany | -- | Notch inhibitor | Anti-fibrosis | Under investigation | Details |
| D593 | GSI | Miscellany | -- | Notch inhibitor | Anti-fibrosis | Under investigation | Details |
| D594 | GalNAc-siTAZ | Miscellany | -- | TAZ inhibitor | Anti-fibrosis | Under investigation | Details |
| D595 | AAV8-ALB-hHNF 4α | Miscellany | -- | -- | Anti-fibrosis | Under investigation | Details |
| D596 | Emodin | Chemical drug | -- | DNA synthesis inhibitors; Protein synthesis inhibitors; Protein tyrosine kinase inhibitors; RNA synthesis inhibitors | Anti-fibrosis | Under investigation | Details |
| D597 | Yellow loosestrife | Herbal medicine | -- | -- | Anti-fibrosis | Under investigation | Details |
| D598 | Tetrodecadazinone | Chemical drug | -- | -- | Anti-fibrosis | Under investigation | Details |
| D599 | TIPE2 | Miscellany | -- | -- | Anti-fibrosis | Under investigation | Details |
| D600 | Oxy210 | Chemical drug | -- | Hedgehog cell-signalling pathway inhibitors; Transforming growth factor beta inhibitors; Virus replication inhibitors | Anti-fibrosis | Under investigation | Details |
| D601 | SP-1154 | Miscellany | -- | -- | Anti-fibrosis | Under investigation | Details |
| D602 | IGF-I | Miscellany | -- | P53 activitor | Anti-fibrosis | Under investigation | Details |