Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A14008 | 29637446 | J Physiol Biochem | Effect of high chronic intake of sucrose on liver metabolism in aging rats. Modulation by rutin and micronutrients. | 2018 | Details |
| A14011 | 29635284 | Endocrinology | Divergent Role of Estrogen-Related Receptor α in Lipid- and Fasting-Induced Hepatic Steatosis in Mice. | 2018 | Details |
| A14020 | 29631603 | Lipids Health Dis | Heat shock protein 70 promotes lipogenesis in HepG2 cells. | 2018 | Details |
| A14022 | 29631096 | Biochim Biophys Acta Mol Cell Biol Lipids | Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis. | 2018 | Details |
| A14032 | 29625129 | Metabolism | A negative feedback loop between microRNA-378 and Nrf1 promotes the development of hepatosteatosis in mice treated with a high fat diet. | 2018 | Details |
| A14043 | 29619530 | Diabetologia | Can targeting ANGPTL proteins improve glucose tolerance? | 2018 | Details |
| A14049 | 29609842 | J Pharmacol Sci | Akebia saponin D alleviates hepatic steatosis through BNip3 induced mitophagy. | 2017 | Details |
| A14079 | 29600657 | Zhongguo Zhong Yao Za Zhi | [Effect of leech on lipid metabolism and liver in hyperlipidemia rats]. | 2018 | Details |
| A14091 | 29593573 | Front Physiol | Rho, a Fraction From Rhodiola crenulate, Ameliorates Hepatic Steatosis in Mice Models. | 2018 | Details |
| A14103 | 29583004 | J Agric Food Chem | Effects of Stigmasterol and β-Sitosterol on Nonalcoholic Fatty Liver Disease in a Mouse Model: A Lipidomic Analysis. | 2018 | Details |
| A14115 | 29575149 | J Cell Biochem | Exercise decreases CLK2 in the liver of obese mice and prevents hepatic fat accumulation. | 2018 | Details |
| A14116 | 29575055 | J Cell Biochem | MicroRNA-190b regulates lipid metabolism and insulin sensitivity by targeting IGF-1 and ADAMTS9 in non-alcoholic fatty liver disease. | 2018 | Details |
| A14123 | 29574225 | Pharmacol Res | Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1/AMPK signaling pathway. | 2018 | Details |
| A14127 | 29572551 | Sci Rep | Lack of evidence supporting a role of TMC4-rs641738 missense variant-MBOAT7- intergenic downstream variant-in the Susceptibility to Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A14128 | 29572342 | J Pharmacol Exp Ther | Protectin DX Ameliorates Hepatic Steatosis by Suppression of Endoplasmic Reticulum Stress via AMPK-Induced ORP150 Expression. | 2018 | Details |
| A14143 | 29565507 | Eur Rev Med Pharmacol Sci | Analysis of the correlation between non-alcoholic fatty liver disease and bone metabolism indicators in healthy middle-aged men. | 2018 | Details |
| A14148 | 29563875 | Front Pharmacol | Mangiferin Improves Hepatic Lipid Metabolism Mainly Through Its Metabolite-Norathyriol by Modulating SIRT-1/AMPK/SREBP-1c Signaling. | 2018 | Details |
| A14165 | 29556076 | Sci Rep | The Nuclear Orphan Receptor Nur77 Alleviates Palmitate-induced Fat Accumulation by Down-regulating G0S2 in HepG2 Cells. | 2018 | Details |
| A14168 | 29555504 | Eur J Pharmacol | Alantolactone suppresses APOC3 expression and alters lipid homeostasis in L02 liver cells. | 2018 | Details |
| A14176 | 29550812 | Cell Physiol Biochem | Lack of ClC-2 Alleviates High Fat Diet-Induced Insulin Resistance and Non-Alcoholic Fatty Liver Disease. | 2018 | Details |
| A14186 | 29544992 | Mol Aspects Med | Omega-3 fatty acids and non-alcoholic fatty liver disease: Evidence of efficacy and mechanism of action. | 2018 | Details |
| A14187 | 29542003 | J Nat Med | Scutellaria baicalensis regulates FFA metabolism to ameliorate NAFLD through the AMPK-mediated SREBP signaling pathway. | 2018 | Details |
| A14206 | 29526820 | Biochim Biophys Acta Mol Basis Dis | Benzbromarone aggravates hepatic steatosis in obese individuals. | 2018 | Details |
| A14210 | 29525610 | Nutr Res | Arctigenin protects against steatosis in WRL68 hepatocytes through activation of phosphoinositide 3-kinase/protein kinase B and AMP-activated protein kinase pathways. | 2018 | Details |
| A14212 | 29523931 | Arch Toxicol | In utero and lactational exposure to BDE-47 promotes obesity development in mouse offspring fed a high-fat diet: impaired lipid metabolism and intestinal dysbiosis. | 2018 | Details |
| A14216 | 29522534 | PLoS One | Niemann-Pick type C2 protein supplementation in experimental non-alcoholic fatty liver disease. | 2018 | Details |
| A14221 | 29519316 | Phytomedicine | CGplus, a standardized herbal composition ameliorates non-alcoholic steatohepatitis in a tunicamycin-induced mouse model. | 2018 | Details |
| A14224 | 29516496 | J Physiol | Primate fetal hepatic responses to maternal obesity: epigenetic signalling pathways and lipid accumulation. | 2018 | Details |
| A14228 | 29515023 | JCI Insight | LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity. | 2018 | Details |
| A14236 | 29511669 | Biomed Res Int | Ethanol Extract from Ulva prolifera Prevents High-Fat Diet-Induced Insulin Resistance, Oxidative Stress, and Inflammation Response in Mice. | 2018 | Details |
| A14238 | 29510489 | Int J Mol Sci | Divergent Role of Sphingosine 1-Phosphate in Liver Health and Disease. | 2018 | Details |
| A14241 | 29508520 | Mol Nutr Food Res | Sugary Kefir Strain Lactobacillus mali APS1 Ameliorated Hepatic Steatosis by Regulation of SIRT-1/Nrf-2 and Gut Microbiota in Rats. | 2018 | Details |
| A14248 | 29507043 | J Endocrinol | Lactobacillus acidophilus NS1 attenuates diet-induced obesity and fatty liver. | 2018 | Details |
| A14250 | 29505790 | Biochem Biophys Res Commun | Berberine alleviates hepatic lipid accumulation by increasing ABCA1 through the protein kinase C δ pathway. | 2018 | Details |
| A14261 | 29497783 | Diabetologia | Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents. | 2018 | Details |
| A14278 | 29486327 | Biochim Biophys Acta Mol Cell Biol Lipids | FTO promotes SREBP1c maturation and enhances CIDEC transcription during lipid accumulation in HepG2 cells. | 2018 | Details |
| A14279 | 29486218 | Toxicology | Cadmium exposure exacerbates hyperlipidemia in cholesterol-overloaded hepatocytes via autophagy dysregulation. | 2018 | Details |
| A14288 | 29482168 | Redox Biol | Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid β-oxidation and ketogenesis via activating XBP1 signaling in liver. | 2018 | Details |
| A14289 | 29481986 | J Nutr Biochem | Replacement of soybean oil by fish oil increases cytosolic lipases activities in liver and adipose tissue from rats fed a high-carbohydrate diets. | 2018 | Details |
| A14291 | 29480487 | Methods Mol Biol | Measurement of AMPK-Induced Inhibition of Lipid Synthesis Flux in Cultured Cells. | 2018 | Details |
| A14299 | 29475944 | J Biol Chem | Hepatic loss of Lissencephaly 1 (Lis1) induces fatty liver and accelerates liver tumorigenesis in mice. | 2018 | Details |
| A14301 | 29474931 | Biochim Biophys Acta Mol Cell Biol Lipids | Alpha-syntrophin null mice are protected from non-alcoholic steatohepatitis in the methionine-choline-deficient diet model but not the atherogenic diet model. | 2018 | Details |
| A14303 | 29472712 | Nat Rev Endocrinol | Direct effects of thyroid hormones on hepatic lipid metabolism. | 2018 | Details |
| A14310 | 29470816 | J Physiol Biochem | Hepatic subcellular distribution of squalene changes according to the experimental setting. | 2018 | Details |
| A14335 | 29462565 | Am J Physiol Endocrinol Metab | Pycnogenol protects against diet-induced hepatic steatosis in apolipoprotein-E-deficient mice. | 2018 | Details |
| A14338 | 29459774 | Sci Rep | Nonylphenol aggravates non-alcoholic fatty liver disease in high sucrose-high fat diet-treated rats. | 2018 | Details |
| A14340 | 29456698 | Exp Ther Med | Correlation of blood glucose, serum chemerin and insulin resistance with NAFLD in patients with type 2 diabetes mellitus. | 2018 | Details |
| A14343 | 29456073 | Cell Metab | An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans. | 2018 | Details |
| A14345 | 29454967 | Biochem Biophys Res Commun | SARM1 deletion restrains NAFLD induced by high fat diet (HFD) through reducing inflammation, oxidative stress and lipid accumulation. | 2018 | Details |
| A14351 | 29452209 | J Hepatol | Prolactin improves hepatic steatosis via CD36 pathway. | 2018 | Details |
| A14385 | 29432786 | Biochimie | Oleic acid induces the novel apolipoprotein O and reduces mitochondrial membrane potential in chicken and human hepatoma cells. | 2018 | Details |
| A14391 | 29430321 | Liver Res | Interaction between stress responses and circadian metabolism in metabolic disease. | 2017 | Details |
| A14392 | 29429624 | Cell Immunol | Macrophages and lipid metabolism. | 2018 | Details |
| A14395 | 29428667 | Biomed Pharmacother | Silybum marianum oil attenuates hepatic steatosis and oxidative stress in high fat diet-fed mice. | 2018 | Details |
| A14404 | 29426937 | Nat Commun | Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation. | 2018 | Details |
| A14420 | 29414781 | J Biol Chem | Maresin 1 attenuates NAFLD by suppression of endoplasmic reticulum stress via AMPK-SERCA2b pathway. | 2018 | Details |
| A14428 | 29411128 | Eur J Appl Physiol | Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease. | 2018 | Details |
| A14435 | 29408694 | J Hepatol | Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. | 2018 | Details |
| A14453 | 29404440 | Hepatol Commun | Engineered FGF19 eliminates bile acid toxicity and lipotoxicity leading to resolution of steatohepatitis and fibrosis in mice. | 2017 | Details |
| A14473 | 29397594 | Zhonghua Nei Ke Za Zhi | [Efficacy of probiotics on the treatment of non-alcoholic fatty liver disease]. | 2018 | Details |
| A14478 | 29391755 | World J Gastroenterol | circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling. | 2018 | Details |
| A14485 | 29389988 | PLoS One | Implication of trans-11,trans-13 conjugated linoleic acid in the development of hepatic steatosis. | 2018 | Details |
| A14494 | 29382663 | Diabetes | Long Noncoding RNA lncSHGL Recruits hnRNPA1 to Suppress Hepatic Gluconeogenesis and Lipogenesis. | 2018 | Details |
| A14497 | 29381226 | J Gastroenterol Hepatol | Risk for the development of non-alcoholic fatty liver disease: A prospective study. | 2018 | Details |
| A14500 | 29379801 | J Diabetes Res | Quercetin Improves Glucose and Lipid Metabolism of Diabetic Rats: Involvement of Akt Signaling and SIRT1. | 2017 | Details |
| A14513 | 29375204 | World J Gastroenterol | Metabolic and hepatic effects of liraglutide, obeticholic acid and elafibranor in diet-induced obese mouse models of biopsy-confirmed nonalcoholic steatohepatitis. | 2018 | Details |
| A14516 | 29373070 | J Med Food | Lipolysis-Stimulating Peptide from Soybean Protects Against High Fat Diet-Induced Apoptosis in Skeletal Muscles. | 2018 | Details |
| A14518 | 29371998 | Toxicol Res | Protective Effect of Isoliquiritigenin against Ethanol-Induced Hepatic Steatosis by Regulating the SIRT1-AMPK Pathway. | 2018 | Details |
| A14525 | 29367725 | Sci Rep | Omentectomy Prevents Metabolic Syndrome By Reducing Appetite and Body Weight In A Diet-Induced Obesity Rat Model. | 2018 | Details |
| A14531 | 29366871 | Food Chem Toxicol | Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice. | 2018 | Details |
| A14534 | 29364302 | Food Funct | Effects of a combined intervention with a lentil protein hydrolysate and a mixed training protocol on the lipid metabolism and hepatic markers of NAFLD in Zucker rats. | 2018 | Details |
| A14542 | 29361464 | Cell Syst | Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease. | 2018 | Details |
| A14543 | 29360762 | Mar Drugs | Protective Effect of Meretrix meretrix Oligopeptides on High-Fat-Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. | 2018 | Details |
| A14553 | 29357123 | Compr Physiol | Triglyceride Metabolism in the Liver. | 2017 | Details |
| A14559 | 29354946 | Zhongguo Zhen Jiu | [Mechanisms of acupuncture for non-alcoholic fatty liver disease: researches progress and prospects]. | 2018 | Details |
| A14563 | 29353208 | Biomed Pharmacother | Natural products berberine and curcumin exhibited better ameliorative effects on rats with non-alcohol fatty liver disease than lovastatin. | 2018 | Details |
| A14564 | 29351486 | Am J Physiol Endocrinol Metab | Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. | 2017 | Details |
| A14565 | 29351427 | Am J Physiol Regul Integr Comp Physiol | Role of PTP1B in POMC neurons during chronic high-fat diet: sex differences in regulation of liver lipids and glucose tolerance. | 2017 | Details |
| A14567 | 29350757 | J Food Sci | Hepatoprotective Effects of Sophoricoside against Fructose-Induced Liver Injury via Regulating Lipid Metabolism, Oxidation, and Inflammation in Mice. | 2018 | Details |
| A14568 | 29350678 | Exp Mol Med | PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis. | 2018 | Details |
| A14577 | 29343420 | EBioMedicine | AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development. | 2018 | Details |
| A14580 | 29342107 | Molecules | Honokiol Improves Liver Steatosis in Ovariectomized Mice. | 2018 | Details |
| A14597 | 29331496 | J Nutr Biochem | Maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation through epigenetic modification in adult offspring rats. | 2017 | Details |
| A14610 | 29325281 | Zhonghua Gan Zang Bing Za Zhi | [Value of hydrogen proton magnetic resonance spectroscopy in the determination of liver triglyceride in patients with fatty liver disease and its influencing factors]. | 2017 | Details |
| A14620 | 29321172 | Diabetes | Modest Decreases in Endogenous All-trans-Retinoic Acid Produced by a Mouse Rdh10 Heterozygote Provoke Major Abnormalities in Adipogenesis and Lipid Metabolism. | 2018 | Details |
| A14647 | 29310441 | Antioxid Redox Signal | Dihydromyricetin Ameliorates Nonalcoholic Fatty Liver Disease by Improving Mitochondrial Respiratory Capacity and Redox Homeostasis Through Modulation of SIRT3 Signaling. | 2018 | Details |
| A14649 | 29309075 | Food Funct | Niga-ichigoside F1 ameliorates high-fat diet-induced hepatic steatosis in male mice by Nrf2 activation. | 2018 | Details |
| A14650 | 29309065 | World J Gastroenterol | Silymarin: An option to treat non-alcoholic fatty liver disease. | 2017 | Details |
| A14659 | 29304731 | BMC Gastroenterol | Safety, tolerability and pharmacodynamics of apical sodium-dependent bile acid transporter inhibition with volixibat in healthy adults and patients with type 2 diabetes mellitus: a randomised placebo-controlled trial. | 2018 | Details |
| A14664 | 29299197 | Iran J Basic Med Sci | Inhibition of 5-lipoxygenase inhibitor zileuton in high-fat diet-induced nonalcoholic fatty liver disease progression model. | 2017 | Details |
| A14668 | 29295869 | Endocr Connect | Macrophage activation marker sCD163 correlates with accelerated lipolysis following LPS exposure: a human-randomised clinical trial. | 2018 | Details |
| A14679 | 29290620 | Mol Metab | Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis. | 2017 | Details |
| A14682 | 31938096 | Int J Clin Exp Pathol | A nonalcoholic fatty liver disease cirrhosis model in gerbil: the dynamic relationship between hepatic lipid metabolism and cirrhosis. | 2018 | Details |
| A14694 | 29286519 | Probl Radiac Med Radiobiol | Comparative characteristics of hepatoprotectors used for the treatment of non alcoholic steatohepatitis associated with herpesvirus infection in sufferers of the Chornobyl accident. | 2017 | Details |
| A14695 | 29286303 | Nutrients | Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD). | 2017 | Details |
| A14696 | 29286302 | Int J Mol Sci | MicroRNA-27b Depletion Enhances Endotrophic and Intravascular Lipid Accumulation and Induces Adipocyte Hyperplasia in Zebrafish. | 2017 | Details |
| A14711 | 29276754 | Cell Mol Gastroenterol Hepatol | Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model. | 2017 | Details |
| A14726 | 29270247 | Oxid Med Cell Longev | Deficiency of the Purinergic Receptor 2X7 Attenuates Nonalcoholic Steatohepatitis Induced by High-Fat Diet: Possible Role of the NLRP3 Inflammasome. | 2017 | Details |
| A14732 | 29266821 | J Diabetes Investig | Angiopoietin-like protein 8/betatrophin correlates with hepatocellular lipid content independent of insulin resistance in non-alcoholic fatty liver disease patients. | 2018 | Details |
| A14733 | 29266812 | Mol Nutr Food Res | Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice. | 2018 | Details |