Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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insulin resistance7794 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A48042 | 25866507 | Gastroenterol Res Pract | Treatment of nonalcoholic steatohepatitis in adults: present and future. | 2015 | Details |
| A48066 | 25255039 | J Med Chem | Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist. | 2014 | Details |
| A48067 | 25213859 | J Biol Chem | Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice. | 2014 | Details |
| A48094 | 24096983 | J Gastroenterol | Occlusion of portosystemic shunts improves hyperinsulinemia due to insulin resistance in cirrhotic patients with portal hypertension. | 2013 | Details |
| A48099 | 23709089 | Endocrinology | High-fat feeding-induced hyperinsulinemia increases cardiac glucose uptake and mitochondrial function despite peripheral insulin resistance. | 2013 | Details |
| A48107 | 23318884 | Lab Invest | Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity. | 2013 | Details |
| A48114 | 22955269 | J Biol Chem | Increased phosphoenolpyruvate carboxykinase gene expression and steatosis during hepatitis C virus subgenome replication: role of nonstructural component 5A and CCAAT/enhancer-binding protein β. | 2012 | Details |
| A48129 | 22248781 | Pediatr Endocrinol Diabetes Metab | [Insulin resistance in children]. | 2011 | Details |
| A48143 | 21519236 | Curr Opin Clin Nutr Metab Care | Osteocalcin: a new link between bone and energy metabolism. Some evolutionary clues. | 2011 | Details |
| A48150 | 21239437 | Endocrinology | Hypermethylation of hepatic glucokinase and L-type pyruvate kinase promoters in high-fat diet-induced obese rats. | 2011 | Details |
| A48161 | 20953409 | Vet Med Int | Lycopene prevents development of steatohepatitis in experimental nonalcoholic steatohepatitis model induced by high-fat diet. | 2010 | Details |
| A48164 | 20861239 | Endocrinology | Caloric restriction reverses hepatic insulin resistance and steatosis in rats with low aerobic capacity. | 2010 | Details |
| A48181 | 20530928 | Nihon Shokakibyo Gakkai Zasshi | A case of systemic lupus erythematosus with liver damage. | 2010 | Details |
| A48191 | 20105583 | J Pediatr Surg | A prospective trial for laparoscopic adjustable gastric banding in morbidly obese adolescents: an interim report of weight loss, metabolic and quality of life outcomes. | 2010 | Details |
| A48212 | 19549744 | J Clin Endocrinol Metab | Thyroid hormone-related regulation of gene expression in human fatty liver. | 2009 | Details |
| A48223 | 19346786 | Korean J Hepatol | [The value of serum retinol-binding protein 4 levels for determining disease severity in patients with chronic liver disease]. | 2009 | Details |
| A48227 | 19183340 | Aliment Pharmacol Ther | Mechanism of action of metformin in nonalcoholic steatohepatitis. | 2009 | Details |
| A48257 | 18316359 | Diabetes | Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis. | 2008 | Details |
| A48270 | 17940115 | J Clin Endocrinol Metab | Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: the effect of long-term leptin therapy. | 2007 | Details |
| A48277 | 17659597 | Hepatology | Metabolic correlates of nonalcoholic fatty liver in women and men. | 2007 | Details |
| A48281 | 17476199 | Med Sci Monit | Cirrhosis in Werner's syndrome: an unusual presentation of premature aging. | 2007 | Details |
| A48292 | 17241893 | Gastroenterology | Insulin resistance: cause or consequence of nonalcoholic steatohepatitis? | 2007 | Details |
| A48294 | 17135591 | N Engl J Med | Thiazolidinediones for nonalcoholic steatohepatitis--promising but not ready for prime time. | 2006 | Details |
| A48295 | 17135584 | N Engl J Med | A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. | 2006 | Details |
| A48298 | 17037330 | Nihon Naika Gakkai Zasshi | [Diagnosis of and therapy for nonalcoholic steatohepatitis]. | 2006 | Details |
| A48306 | 16998299 | Korean J Hepatol | [Nonalcoholic steatohepatitis]. | 2006 | Details |
| A48317 | 30290456 | Expert Rev Endocrinol Metab | Obesity, insulin resistance, Type 2 diabetes and free fatty acids. | 2006 | Details |
| A48319 | 16772767 | Am J Ther | Highly active antiretroviral therapy-associated metabolic syndrome: pathogenesis and cardiovascular risk. | 2006 | Details |
| A48325 | 16522283 | Curr Diab Rep | Metabolic syndrome in the elderly. | 2006 | Details |
| A48334 | 16256425 | Hepatol Res | Nonalcoholic steatohepatitis in Asia-Oceania. | 2005 | Details |
| A48338 | 16181372 | Am J Gastroenterol | Hepatic steatosis in Dunnigan-type familial partial lipodystrophy. | 2005 | Details |
| A48341 | 16128278 | Pol Arch Med Wewn | [Effect of high-fat diet, rosiglitazone on lipid profile, insulin resistance and liver steatosis development]. | 2005 | Details |
| A48351 | 15625648 | Clin Gastroenterol Hepatol | Treatment of nonalcoholic steatohepatitis: antioxidants or insulin sensitizers? | 2004 | Details |
| A48354 | 15570868 | Nihon Shokakibyo Gakkai Zasshi | [Treatment of nonalcoholic steatohepatitis (NASH)]. | 2004 | Details |
| A48361 | 15240593 | J Clin Endocrinol Metab | Proteinuric nephropathy in acquired and congenital generalized lipodystrophy: baseline characteristics and course during recombinant leptin therapy. | 2004 | Details |
| A48376 | 14557475 | J Clin Endocrinol Metab | Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver. | 2003 | Details |
| A48383 | 12866461 | Nihon Naika Gakkai Zasshi | [Recent topics on nonalcoholic steatohepatitis]. | 2003 | Details |
| A48388 | 12768401 | J Gastroenterol | "Insufficient" leptin production for the fat mass: a risk factor for nonalcoholic steatohepatitis in obese patients? | 2003 | Details |
| A48392 | 12663460 | Diabetes | Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma. | 2003 | Details |
| A48400 | 12464976 | Can J Gastroenterol | Serum levels of triglyceride and insulin resistance in patients with nonalcoholic steatohepatitis. | 2002 | Details |
| A48403 | 12364344 | Hypertension | Obesity hypertension in children: a problem of epidemic proportions. | 2002 | Details |
| A48429 | 11232664 | Am J Gastroenterol | Insulin resistance and nonalcoholic steatohepatitis: fat or fiction? | 2001 | Details |
| A48530 | 34647189 | Diabetes Ther | Are the Protean Effects of Pentoxifylline in the Therapy of Diabetes and Its Complications Still Relevant? | 2021 | Details |
| A48533 | 34616107 | J Clin Biochem Nutr | Spirulina platensis and its ingredient biopterin glucoside improved insulin sensitivity in non-alcoholic steatohepatitis model. | 2021 | Details |
| A48573 | 33815359 | Front Immunol | Adipocyte Fatty Acid-Binding Protein, Cardiovascular Diseases and Mortality. | 2021 | Details |
| A48582 | 33659253 | Front Cell Dev Biol | Polarization of Macrophages in Insects: Opening Gates for Immuno-Metabolic Research. | 2021 | Details |
| A48597 | 33387847 | Cell Calcium | Role of mitochondria in liver metabolic health and diseases. | 2020 | Details |
| A48639 | 32592089 | J Physiol Biochem | Lactosylceramide induced by elastin-derived peptides decreases adipocyte differentiation. | 2020 | Details |
| A48656 | 32195457 | JHEP Rep | miR-22 inhibition reduces hepatic steatosis via FGF21 and FGFR1 induction. | 2020 | Details |
| A48672 | 31823815 | Hum Genomics | Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease. | 2019 | Details |
| A48696 | 31368881 | Endocr Metab Immune Disord Drug Targets | Key Relevance of Epigenetic Programming of Adiponectin Gene in Pathogenesis of Metabolic Disorders. | 2020 | Details |
| A48736 | 30305645 | Sci Rep | Hesperidin and capsaicin, but not the combination, prevent hepatic steatosis and other metabolic syndrome-related alterations in western diet-fed rats. | 2018 | Details |
| A48755 | 29611411 | Yonsei Med J | Erratum to "Pathologic Impact of Insulin Resistance and Sensitivity on the Severity of Liver Histopathology in Pediatric Non-Alcoholic Steatohepatitis" by Park BH, et al. (Yonsei Med J 2017;58:756-762.). | 2018 | Details |
| A48789 | 28711599 | Biochim Biophys Acta Mol Basis Dis | Arachidonic acid sex-dependently affects obesity through linking gut microbiota-driven inflammation to hypothalamus-adipose-liver axis. | 2017 | Details |
| A48811 | 27775791 | Eur Rev Med Pharmacol Sci | Association between irisin and major chronic diseases: a review. | 2016 | Details |
| A48826 | 27467521 | PLoS One | Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice. | 2016 | Details |
| A48836 | 27003699 | Obes Surg | The Effect of Roux-en-Y vs. Omega-Loop Gastric Bypass on Liver, Metabolic Parameters, and Weight Loss. | 2016 | Details |
| A48850 | 26680665 | Physiol Res | Fasting and nonfasting triglycerides in cardiovascular and other diseases. | 2015 | Details |
| A48910 | 24804175 | Liver Cancer | Hepatic iron overload and hepatocellular carcinoma. | 2014 | Details |
| A48932 | 24090942 | Best Pract Res Clin Gastroenterol | Liver abnormalities and endocrine diseases. | 2013 | Details |
| A48933 | 24068196 | Int J Mol Med | Metformin decreases high-fat diet-induced renal injury by regulating the expression of adipokines and the renal AMP-activated protein kinase/acetyl-CoA carboxylase pathway in mice. | 2013 | Details |
| A48934 | 24032513 | Mini Rev Med Chem | Triglyceride Metabolism and Hepatic Diseases. | 2013 | Details |
| A48942 | 23700549 | Adipocyte | Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice. | 2013 | Details |
| A48964 | 23027617 | Carcinogenesis | Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice. | 2012 | Details |
| A48971 | 22801434 | Panminerva Med | Metabolic derangements mediate cognitive impairment and Alzheimer's disease: role of peripheral insulin-resistance diseases. | 2012 | Details |
| A48972 | 22721876 | Nutrition | Caffeine attenuates metabolic syndrome in diet-induced obese rats. | 2012 | Details |
| A48984 | 22337830 | J Alzheimers Dis | Triangulated mal-signaling in Alzheimer's disease: roles of neurotoxic ceramides, ER stress, and insulin resistance reviewed. | 2012 | Details |
| A48991 | 22182059 | Scand J Gastroenterol | Circulating vaspin and its relationship with insulin sensitivity, adiponectin and liver histology in subjects with non-alcoholic steatohepatitis. | 2011 | Details |
| A49000 | 21951092 | Dig Endosc | Non-alcoholic steatohepatitis mimicking liver metastasis in obesity surgery. | 2011 | Details |
| A49009 | 21466434 | Curr Pharm Biotechnol | Silymarin in the prevention and treatment of liver diseases and primary liver cancer. | 2012 | Details |
| A49013 | 21329534 | Ned Tijdschr Geneeskd | [Diabetes mellitus and cirrhosis of the liver: a prognostically unfavourable combination]. | 2011 | Details |
| A49022 | 21112115 | J Hepatol | Insulin resistance and oxidative stress: two therapeutic targets in non-alcoholic steatohepatitis. | 2010 | Details |
| A49023 | 21103235 | Case Rep Gastroenterol | Non-Alcoholic Steatohepatitis in Myotonic Dystrophy: DMPK Gene Mutation, Insulin Resistance and Development of Steatohepatitis. | 2010 | Details |
| A49028 | 20953861 | Diabetologia | Targeting energy expenditure via fuel switching and beyond. | 2010 | Details |
| A49036 | 20570793 | Orv Hetil | [Role of environmental factors in the etiology of hepatocellular carcinoma]. | 2010 | Details |
| A49054 | 19906067 | Cancer Sci | Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice. | 2009 | Details |
| A49066 | 19538246 | Diabet Med | Insulin resistance and endothelial dysfunction in type 2 diabetic patients with non-alcoholic steatohepatitis. | 2009 | Details |
| A49079 | 18793162 | Biochem Soc Trans | NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? | 2008 | Details |
| A49090 | 18400637 | Anadolu Kardiyol Derg | [Global confusion on the diagnostic criteria for metabolic syndrome: what is the point that guidelines can not agree?]. | 2008 | Details |
| A49094 | 18290780 | Liver Int | Previous practice of high-intensity sports as a risk factor for non-alcoholic steatohepatitis. | 2008 | Details |
| A49106 | 17435339 | Nihon Yakurigaku Zasshi | [Candidate drugs for non-alcoholic steatohepatitis (NASH)]. | 2007 | Details |
| A49125 | 16622296 | Endocrine | Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome. | 2006 | Details |
| A49126 | 16610061 | World J Gastroenterol | Cryptogenic cirrhosis in the region where obesity is not prevalent. | 2006 | Details |
| A49134 | 16499208 | Nihon Naika Gakkai Zasshi | [Non-alcoholic steatohepatitis. 3. Oxidative stress and NASH]. | 2006 | Details |
| A49135 | 16499207 | Nihon Naika Gakkai Zasshi | [Non-alcoholic steatohepatitis (NASH). 2. Insulin resistance and NASH]. | 2006 | Details |
| A49147 | 16225471 | Aliment Pharmacol Ther | Review article: steatosis, the metabolic syndrome and cancer. | 2005 | Details |
| A49153 | 16165706 | Scand J Gastroenterol | Invasive and non-invasive investigations for non-alcoholic steatohepatitis: the benefit of histology. | 2005 | Details |
| A49154 | 16137475 | Gastroenterol Hepatol | [Etiopathogenesis of non-alcoholic steatohepatitis]. | 2005 | Details |
| A49156 | 16097995 | Aliment Pharmacol Ther | Ciprofloxacin suppresses bacterial overgrowth, increases fasting insulin but does not correct low acylated ghrelin concentration in non-alcoholic steatohepatitis. | 2005 | Details |
| A49165 | 15698360 | Med J Aust | 3. Management and prevention of obesity and its complications in children and adolescents. | 2005 | Details |
| A49169 | 15641470 | Gac Med Mex | [Obesity and steatohepatitis. Histologic aspects]. | 2005 | Details |
| A49175 | 15489566 | Eur J Gastroenterol Hepatol | Mitochondrial injury in steatohepatitis. | 2004 | Details |
| A49184 | 15094675 | Gastroenterol Clin Biol | [Improving insulin resistance: certain progress in the management of patients with non-alcoholic steatohepatitis...but the story continues]. | 2004 | Details |
| A49185 | 15040152 | Vnitr Lek | [The metabolic syndrome]. | 2003 | Details |
| A49187 | 14987322 | Aliment Pharmacol Ther | Metformin in the treatment of patients with non-alcoholic steatohepatitis. | 2004 | Details |
| A49203 | 35830037 | Arq Gastroenterol | OBSTRUCTIVE SLEEP APNEA SYNDROME RISK IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE IS ASSOCIATED WITH OBESITY AND PRESENCE OF NASH. | 2022 | Details |
| A49208 | 35822119 | JGH Open | Efficacy and safety of oral semaglutide in patients with non-alcoholic fatty liver disease complicated by type 2 diabetes mellitus: A pilot study. | 2022 | Details |
| A49210 | 35821558 | Curr Diab Rep | Lipodystrophy for the Diabetologist-What to Look For. | 2022 | Details |
| A49214 | 35817677 | J Diabetes Complications | Non-alcoholic fatty liver disease and sarcopenia is associated with the risk of albuminuria independent of insulin resistance, and obesity. | 2022 | Details |
| A49216 | 35820743 | BMJ Open | Efficacy and safety of guanabenz acetate treatment for non-alcoholic fatty liver disease: a study protocol for a randomised investigator-initiated phase IIa study. | 2022 | Details |