Repositioning Candidates
Repositioning candidates for NAFLD are derived from DrugBank which fall into three categories: therapeutic strategy-associated, target-associated, and indication-associated candidates. For each candidate, detailed properties are extracted from DrugBank, and related strategies, target and NAFLD-associated disease in NAFLDkb are presented with knowledge graphs.
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Search for:
3-hydroxy-3-methylglutaryl-coenzyme A reductase18 records.
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0055 | DB00157 | approved; nutraceutical | small molecule | NADH | Target associated | Details |
| R0062 | DB00175 | approved | small molecule | Pravastatin | Target associated | Details |
| R0088 | DB00227 | approved; investigational | small molecule | Lovastatin | Therapeutic strategy associated | Details |
| R0147 | DB00439 | approved; withdrawn | small molecule | Cerivastatin | Target associated | Details |
| R0227 | DB00641 | approved | small molecule | Simvastatin | Therapeutic strategy associated | Details |
| R0402 | DB01095 | approved | small molecule | Fluvastatin | Target associated | Details |
| R0557 | DB01992 | investigational; nutraceutical | small molecule | Coenzyme A | Target associated | Details |
| R0576 | DB03169 | experimental | small molecule | (S)-Hmg-Coa | Target associated | Details |
| R0584 | DB03461 | experimental | small molecule | Nicotinamide adenine dinucleotide phosphate | Target associated | Details |
| R0587 | DB03518 | experimental | small molecule | Mevalonic acid | Target associated | Details |
| R0592 | DB03785 | experimental | small molecule | Mevinolinic acid | Target associated | Details |
| R0602 | DB04377 | experimental | small molecule | Meglutol | Target associated | Details |
| R0603 | DB04447 | experimental | small molecule | 1,4-Dithiothreitol | Target associated | Details |
| R0769 | DB05317 | investigational | small molecule | TAK-475 | Target associated | Details |
| R1082 | DB06693 | experimental | small molecule | Mevastatin | Target associated | Details |
| R1208 | DB09061 | approved; investigational | small molecule | Cannabidiol | Therapeutic strategy associated | Details |
| R1513 | DB14009 | experimental; investigational | biotech | Medical Cannabis | Target associated | Details |
| R1514 | DB14011 | investigational | small molecule | Nabiximols | Target associated | Details |