Repositioning Candidates

Repositioning candidates for NAFLD are derived from DrugBank which fall into three categories: therapeutic strategy-associated, target-associated, and indication-associated candidates. For each candidate, detailed properties are extracted from DrugBank, and related strategies, target and NAFLD-associated disease in NAFLDkb are presented with knowledge graphs.

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1608 records.
Candidate ID Source ID Source Type Compound Type Candidate Name Inclusion Criteria
R1101 DB06789 approved; investigational small molecule Hydroxyprogesterone caproate Therapeutic strategy associated Details
R1102 DB06791 approved small molecule Lanreotide Therapeutic strategy associated Details
R1103 DB06795 approved; vet_approved small molecule Mafenide Indication associated Details
R1104 DB06800 approved small molecule Methylnaltrexone Indication associated Details
R1105 DB06812 approved small molecule Povidone-iodine Therapeutic strategy associated Details
R1106 DB06813 approved; investigational small molecule Pralatrexate Therapeutic strategy associated Details
R1107 DB06824 approved; investigational small molecule Triethylenetetramine Therapeutic strategy associated Details
R1108 DB06826 approved; investigational small molecule Unoprostone Indication associated Details
R1109 DB06862 experimental small molecule 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID Target associated Details
R1110 DB06908 experimental small molecule (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID Target associated Details
R1111 DB06926 experimental small molecule (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid Target associated Details
R1112 DB07053 experimental small molecule 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID Target associated Details
R1113 DB07070 experimental small molecule (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid Target associated Details
R1114 DB07111 experimental small molecule (4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid Target associated Details
R1115 DB07172 experimental small molecule (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid Target associated Details
R1116 DB07208 experimental small molecule (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid Target associated Details
R1117 DB07209 experimental small molecule (8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid Target associated Details
R1118 DB07215 investigational small molecule GW-590735 Target associated Details
R1119 DB07302 experimental small molecule 9(S)-HODE Target associated Details
R1120 DB07425 investigational small molecule Sobetirome Target associated Details
R1121 DB07509 experimental small molecule difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron Target associated Details
R1122 DB07565 approved small molecule Chloramphenicol succinate Indication associated Details
R1123 DB07675 experimental small molecule (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID Target associated Details
R1124 DB07691 experimental small molecule 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid Target associated Details
R1125 DB07696 experimental small molecule methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate Target associated Details
R1126 DB07723 experimental small molecule 3-(5-methoxy-1H-indol-3-yl)propanoic acid Target associated Details
R1127 DB07724 experimental small molecule Indeglitazar Target associated Details
R1128 DB07733 experimental small molecule 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE Target associated Details
R1129 DB07744 experimental small molecule Z-Val-Ala-Asp fluoromethyl ketone Target associated Details
R1130 DB07842 experimental small molecule (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid Target associated Details
R1131 DB07863 experimental small molecule 2-chloro-5-nitro-N-phenylbenzamide Target associated Details
R1132 DB07870 experimental small molecule Haloxyfop-P Target associated Details
R1133 DB07916 experimental small molecule 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID Target associated Details
R1134 DB08078 experimental small molecule {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid Target associated Details
R1135 DB08085 experimental small molecule 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE Target associated Details
R1136 DB08121 experimental small molecule (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid Target associated Details
R1137 DB08213 experimental small molecule 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE Target associated Details
R1138 DB08220 experimental small molecule (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid Target associated Details
R1139 DB08229 experimental small molecule [N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid Target associated Details
R1140 DB08231 experimental small molecule Myristic acid Target associated Details
R1141 DB08251 experimental small molecule 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID Target associated Details
R1142 DB08302 experimental small molecule 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid Target associated Details
R1143 DB08402 experimental small molecule 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID Target associated Details
R1144 DB08435 experimental small molecule (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid Target associated Details
R1145 DB08497 experimental small molecule (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate Target associated Details
R1146 DB08498 experimental small molecule (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate Target associated Details
R1147 DB08499 experimental small molecule N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide Target associated Details
R1148 DB08560 experimental small molecule 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE Target associated Details
R1149 DB08604 approved; investigational small molecule Triclosan Target associated Details
R1150 DB08760 experimental small molecule (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid Target associated Details
R1151 DB08798 experimental small molecule Sulfamoxole Indication associated Details
R1152 DB08804 approved; illicit small molecule Nandrolone decanoate Indication associated Details
R1153 DB08807 experimental small molecule Bopindolol Indication associated Details
R1154 DB08808 experimental small molecule Bupranolol Indication associated Details
R1155 DB08813 approved; investigational small molecule Nadroparin Indication associated Details
R1156 DB08814 approved; investigational small molecule Triflusal Indication associated Details
R1157 DB08816 approved small molecule Ticagrelor Therapeutic strategy associated Details
R1158 DB08818 approved; vet_approved small molecule Hyaluronic acid Therapeutic strategy associated Details
R1159 DB08819 approved small molecule Tafluprost Indication associated Details
R1160 DB08820 approved small molecule Ivacaftor Therapeutic strategy associated Details
R1161 DB08822 approved; investigational small molecule Azilsartan medoxomil Target associated Details
R1162 DB08827 approved; investigational small molecule Lomitapide Indication associated Details
R1163 DB08830 experimental small molecule Dehydroascorbic acid Indication associated Details
R1164 DB08834 experimental; investigational small molecule Tauroursodeoxycholic acid Indication associated Details
R1165 DB08835 experimental small molecule Spaglumic acid Therapeutic strategy associated Details
R1166 DB08836 experimental; investigational small molecule Temocapril Indication associated Details
R1167 DB08838 experimental small molecule Agmatine Therapeutic strategy associated Details
R1168 DB08842 approved; investigational small molecule Acetylcarnitine Therapeutic strategy associated Details
R1169 DB08844 investigational small molecule Uric acid Therapeutic strategy associated Details
R1170 DB08862 approved; investigational small molecule Cholecystokinin Therapeutic strategy associated Details
R1171 DB08867 approved small molecule Ulipristal Therapeutic strategy associated Details
R1172 DB08870 approved; investigational biotech Brentuximab vedotin Target associated Details
R1173 DB08874 approved small molecule Fidaxomicin Therapeutic strategy associated Details
R1174 DB08877 approved small molecule Ruxolitinib Therapeutic strategy associated Details
R1175 DB08879 approved biotech Belimumab Target associated Details
R1176 DB08880 approved small molecule Teriflunomide Therapeutic strategy associated Details
R1177 DB08881 approved small molecule Vemurafenib Therapeutic strategy associated Details
R1178 DB08887 approved; investigational; nutraceutical small molecule Icosapent ethyl Therapeutic strategy associated Details
R1179 DB08889 approved; investigational small molecule Carfilzomib Therapeutic strategy associated Details
R1180 DB08890 approved small molecule Linaclotide Therapeutic strategy associated Details
R1181 DB08895 approved; investigational small molecule Tofacitinib Therapeutic strategy associated Details
R1182 DB08899 approved small molecule Enzalutamide Therapeutic strategy associated Details
R1183 DB08904 approved biotech Certolizumab pegol Therapeutic strategy associated Details
R1184 DB08908 approved; investigational small molecule Dimethyl fumarate Therapeutic strategy associated Details
R1185 DB08910 approved small molecule Pomalidomide Therapeutic strategy associated Details
R1186 DB08911 approved small molecule Trametinib Therapeutic strategy associated Details
R1187 DB08915 investigational small molecule Aleglitazar Target associated Details
R1188 DB08931 approved small molecule Riociguat Therapeutic strategy associated Details
R1189 DB08932 approved small molecule Macitentan Indication associated Details
R1190 DB08949 approved; withdrawn small molecule Inositol nicotinate Therapeutic strategy associated Details
R1191 DB08995 approved; investigational small molecule Diosmin Therapeutic strategy associated Details
R1192 DB09006 experimental small molecule Clinofibrate Target associated Details
R1193 DB09012 experimental; withdrawn small molecule Carbazochrome Therapeutic strategy associated Details
R1194 DB09020 approved small molecule Bisacodyl Indication associated Details
R1195 DB09026 approved; investigational small molecule Aliskiren Indication associated Details
R1196 DB09030 approved small molecule Vorapaxar Therapeutic strategy associated Details
R1197 DB09031 approved; investigational small molecule Miltefosine Therapeutic strategy associated Details
R1198 DB09033 approved biotech Vedolizumab Therapeutic strategy associated Details
R1199 DB09042 approved small molecule Tedizolid phosphate Indication associated Details
R1200 DB09043 approved biotech Albiglutide Target associated Details