Investigational Drugs
Investigational drugs for NAFLD are derived from global clinical trials with the latest progress, and detailed drug properties are extracted from DrugBank and PubChem. For each drug, related therapeutic strategies, targets, and clinical trials in NAFLDkb are presented with knowledge graphs.
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inflammatory59 records.
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D002 | Acetaminophen | Chemical drug | DB00316 | PTGES3 inhibitor; TRPV1 activator | Antipyretic drug; non-narcotic analgesic | Under clinical trials | Details |
| D008 | Alpha-tocopherol | Chemical drug | DB00163 | NR1I2; ALOX5; DGKA | -- | Under clinical trials | Details |
| D009 | ALS-L1023 | Chemical drug | -- | PPARA / Angiogenesis | Anti-inflammatory | Under clinical trials | Details |
| D011 | Anthocyanin | Chemical drug | -- | -- | Anti-inflammatory | Failed in clinical trials | Details |
| D018 | Aspirin | Chemical drug | DB00945 | AKR1C1 inhibitor; PCNA downregulator | Enhance lipid metabolism | Under clinical trials | Details |
| D019 | Astaxanthin | Chemical drug | DB06543 | -- | -- | Under clinical trials | Details |
| D025 | Azithromycin | Chemical drug | DB00207 | -- | -- | Under clinical trials | Details |
| D027 | Bayberry Juice | Biological extract | -- | -- | -- | Under clinical trials | Details |
| D033 | Bezafibrate | Chemical drug | DB01393 | PPARA agonist; PPARD agonist; PPARG agonist; NR1I2 partial agonist | Improve insulin resistance; Anti-inflammatory | Under clinical trials | Details |
| D043 | Bismuth subcitrate | Chemical drug | DB09275 | -- | -- | Under clinical trials | Details |
| D054 | Calcitriol | Supplement | DB00136 | -- | -- | Under clinical trials | Details |
| D080 | Citrulline | Chemical drug | DB00155 | -- | -- | Under clinical trials | Details |
| D092 | Curcumin | Chemical drug | DB11672 | PPARG; COX inhibitor | Anticancer agent; NSAID | Under clinical trials | Details |
| D105 | DHA | Chemical drug | DB03756 | PPARA ligand; PPARG ligand | Anti-inflammatory | Under clinical trials | Details |
| D107 | Diacerein | Chemical drug | DB11994 | ALOX5 inhibitor | Antiarthritic drug; antiinflammatory agent | Under clinical trials | Details |
| D114 | Doxycycline | Chemical drug | DB00254 | -- | -- | Under clinical trials | Details |
| D119 | Elafibranor | Chemical drug | DB05187 | PPARA; PPARD; PPARG | Anti-inflammatory | Failed in clinical trials | Details |
| D122 | Empagliflozin | Chemical drug | DB09038 | SLC5A2 inhibitor; SGLT-2 inhibitor | Improve insulin resistance | Under clinical trials | Details |
| D123 | Emricasan | Chemical drug | DB05408 | caspase inhibitor | Anti-inflammatory | Failed in clinical trials | Details |
| D124 | EPA-E | Chemical drug | -- | DGAT1 inhibitor; PLA2 inhibitor | Antiinflammatory agent; Neuroprotective drug | Failed in clinical trials | Details |
| D125 | Epanova | Chemical drug | DB11133 | PPARG ligand; PPARA activator | Enhance lipid metabolism | Under clinical trials | Details |
| D126 | Ergocalciferol | Supplement | DB00153 | VDR agonist; VDR modulator | Calcium regulator; Vitamin source drug | Under clinical trials | Details |
| D133 | Fenofibrate | Chemical drug | DB01039 | PPARA agonist; NR1I2 partial agonist | Anti-inflammatory | Under clinical trials | Details |
| D137 | Fish oil | Biological drug | DB13961 | -- | -- | Under clinical trials | Details |
| D138 | Flaxseed | Biological drug | DB10708 | -- | Anti-inflammatory; Antioxidant; Antineoplastic drug | Under clinical trials | Details |
| D192 | JKB-121 | Chemical drug | DB06230 | TLR4 antagonist | Anti-inflammatory | Under clinical trials | Details |
| D193 | JKB-122 | Miscellany | -- | TLR4 antagonist | Anti-inflammatory | Under clinical trials | Details |
| D217 | Mastiha | Biological extract | -- | -- | -- | Under clinical trials | Details |
| D258 | Omega 3 PUFA | Chemical drug | DB11133 | PPARG ligand; PPARA activator | Hypolipidemic drug | Under clinical trials | Details |
| D265 | Pemafibrate | Chemical drug | DB15212 | PPARA modulator | Anti-inflammatory | Under clinical trials | Details |
| D266 | Pentoxifylline | Chemical drug | DB00806 | ADORA2A antagonist; ADORA1 antagonist; PDE4A inhibitor; PDE3B inhibitor; PDE4B inhibitor; PDE5A inhibitor; PDE8A inhibitor; PDE4C inhibitor; PDE11A inhibitor; PDE7A inhibitor; PDE7B inhibitor; PDE4D inhibitor; PDE3A inhibitor | Anti-inflammatory; Cardiovascular drug | Under clinical trials | Details |
| D301 | Resveratrol | Chemical drug | DB02709 | ALOX15; ALOX5; AHR; NR1I2; NR1I3 | Anticancer agent | Under clinical trials | Details |
| D304 | Rifaximin | Chemical drug | DB01220 | NR1I2 agonist | Antibiotic drug | Under clinical trials | Details |
| D307 | Roflumilast | Chemical drug | DB01656 | PDE4C inhibitor; PDE4B inhibitor; Pde4 inhibitor; PDE4A inhibitor; PDE4D inhibitor | Antiasthmatic drug | Under clinical trials | Details |
| D311 | Rosiglitazone | Chemical drug | DB00412 | PPARG agonist; PPARA; PPARD | Improve insulin resistance | Failed in clinical trials | Details |
| D312 | Rosuvastatin | Chemical drug | DB01098 | HMGCR inhibitor | Enhance lipid metabolism | Under clinical trials | Details |
| D316 | S-adenosyl-L-methionine | Chemical drug | DB00118 | GNMT cofactor | Antiviral | Under clinical trials | Details |
| D318 | Salsalate | Chemical drug | DB01399 | PTGS2 inhibitor; PTGS1 inhibitor | NSAID | Under clinical trials | Details |
| D323 | Secukinumab | Biological drug | DB09029 | IL17A antagonist; antibody | Immunomodulator | Under clinical trials | Details |
| D336 | Silymarin | Biological drug | DB14375 | -- | Antiviral; Antioxidant; Antifibrotic; Anti-inflammatory | Under clinical trials | Details |
| D342 | Solithromycin | Chemical drug | DB09308 | NF-kB inhibitor | Antibiotic drug, anti-inflammatory | Under clinical trials | Details |
| D360 | Telmisartan | Chemical drug | DB00966 | PPARG partial agonist | Improve insulin resistance | Under clinical trials | Details |
| D380 | TVB-2640 | Chemical drug | -- | FASN inhibitor | Enhance lipid metabolism; Anticancer agent | Under clinical trials | Details |
| D381 | Ursodeoxycholic acid | Chemical drug | DB01586 | AKR1C2 inducer | Anti-inflammatory | Under clinical trials | Details |
| D388 | Vitamin E | Supplement | DB00163 | NR1I2; ALOX5; DGKA | Anti-inflammatory | Under clinical trials | Details |
| D395 | Zinc | Chemical drug | DB01593 | PSPH; CCS; HDAC1 cofactor; HDAC4 cofactor; INS; UTRN; ASPA cofactor; TP73 cofactor; A2M; AGT; APOBR; APOE; APOL1; C3; C5; CFB; CFH; CFI; CLU; CP; CPN2; DSP; F12; F13B; FGA; GSN; HBB; HPR; JUP; SELENOP; TTR; VTN | -- | Under clinical trials | Details |
| D465 | Amlexanox | Chemical drug | DB01025 | -- | -- | Under clinical trials | Details |
| D496 | Montelukast | Chemical drug | DB00471 | -- | -- | Under clinical trials | Details |
| D497 | Namodenoson | Chemical drug | -- | A3 adenosine receptor agonist | Anti-inflammatory | Under clinical trials | Details |
| D525 | Dava AL-balgham | Traditional medicine | -- | -- | anti-inflammatory; Anti Atherogenic; antioxidants | Under clinical trials | Details |