Investigational Drugs

Investigational drugs for NAFLD are derived from global clinical trials with the latest progress, and detailed drug properties are extracted from DrugBank and PubChem. For each drug, related therapeutic strategies, targets, and clinical trials in NAFLDkb are presented with knowledge graphs.

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     Intestinal
33 records.
Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
D001 Acarbose Chemical drug DB00284 MGAM inhibitor;AMY2A inhibitor; AMY2B inhibitor; GAA inhibitor Improve insulin resistance Under clinical trials Details
D054 Calcitriol Supplement DB00136 -- -- Under clinical trials Details
D074 Cholestyramine Chemical drug DB01432 -- Hypolipidemic drug Under clinical trials Details
D096 Dabigatran Etexilate Chemical drug DB06695 thrombin inhibitor -- Under clinical trials Details
D120 Elobixibat Chemical drug DB12486 SLC10A1 inhibitor Gastrointestinal drug Under clinical trials Details
D122 Empagliflozin Chemical drug DB09038 SLC5A2 inhibitor; SGLT-2 inhibitor Improve insulin resistance Under clinical trials Details
D126 Ergocalciferol Supplement DB00153 VDR agonist; VDR modulator Calcium regulator; Vitamin source drug Under clinical trials Details
D131 Ezetimibe Chemical drug DB00973 SOAT1 inhibitor; Enhance lipid metabolism Under clinical trials Details
D140 Folic acid Supplement DB00158 FOLR2 binder -- Under clinical trials Details
D155 Glucagon Biological drug DB00040 GCGR agonist Antidiabetic drug Under clinical trials Details
D157 Glucophage Chemical drug DB00331 -- -- Under clinical trials Details
D196 Lactobacillus acidophilus Biological drug DB15823 -- -- Under clinical trials Details
D198 Lactulose Chemical drug DB00581 -- -- Under clinical trials Details
D203 Levothyroxine Chemical drug DB00451 THRA agonist; THRB agonist Anti-fibrosis Under clinical trials Details
D212 Lubiprostone Chemical drug DB01046 -- -- Under clinical trials Details
D225 Metformin Chemical drug DB00331 PRKAB1 inducer activator; ETEDH inhibitor; GPD1 inhibitor Improve insulin resistance Under clinical trials Details
D242 Nigella Sativa Biological extract -- -- Gastrointestinal drug Under clinical trials Details
D243 Nitazoxanide Chemical drug DB00507 POR inhibitor Antiprotozoal drug Under clinical trials Details
D248 Obeticholic Acid Chemical drug DB05990 NR1H4 activator; NR1H4 agonist; FXR agonist Enhance lipid metabolism Approval rejected Details
D260 Orlistat Chemical drug DB01083 FASN inhibitor Enhance lipid metabolism Under clinical trials Details
D264 Pantoprazole Chemical drug DB00213 gastric H-K-ATPase inhibitor; ATP4B inhibitor; ATP4A inhibitor Gastrointestinal drug Under clinical trials Details
D279 Plantago Psyllium Biological drug DB11097 -- -- Under investigation Details
D283 Proanthocyanidin Chemical drug DB04941 CFTR antagonist -- Under clinical trials Details
D304 Rifaximin Chemical drug DB01220 NR1I2 agonist Antibiotic drug Under clinical trials Details
D318 Salsalate Chemical drug DB01399 PTGS2 inhibitor; PTGS1 inhibitor NSAID Under clinical trials Details
D322 Sebelipase Alfa Biological drug DB11563 -- Enzyme replacement therapy Under clinical trials Details
D358 TAF Chemical drug DB09299 -- -- Under clinical trials Details
D381 Ursodeoxycholic acid Chemical drug DB01586 AKR1C2 inducer Anti-inflammatory Under clinical trials Details
D383 Vildagliptin Chemical drug DB04876 DPP4 inhibitor Antidiabetic drug Under clinical trials Details
D384 Vitamin B12 Supplement DB00115 MTHFR cofactor -- Under clinical trials Details
D387 Vitamin D Supplement DB11094 -- Vitamin source drug Under clinical trials Details
D395 Zinc Chemical drug DB01593 PSPH; CCS; HDAC1 cofactor; HDAC4 cofactor; INS; UTRN; ASPA cofactor; TP73 cofactor; A2M; AGT; APOBR; APOE; APOL1; C3; C5; CFB; CFH; CFI; CLU; CP; CPN2; DSP; F12; F13B; FGA; GSN; HBB; HPR; JUP; SELENOP; TTR; VTN -- Under clinical trials Details
D541 Olmesartan Chemical drug DB00275 -- -- Under clinical trials Details