Investigational Drugs
Investigational drugs for NAFLD are derived from global clinical trials with the latest progress, and detailed drug properties are extracted from DrugBank and PubChem. For each drug, related therapeutic strategies, targets, and clinical trials in NAFLDkb are presented with knowledge graphs.
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581 records.
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D203 | Levothyroxine | Chemical drug | DB00451 | THRA agonist; THRB agonist | Anti-fibrosis | Under clinical trials | Details |
| D204 | Licogliflozin | Chemical drug | DB15048 | SGLT1 inhibitor; SGLT2 inhibitor | Improve insulin resistance | Under clinical trials | Details |
| D205 | Linagliptin | Chemical drug | DB08882 | DPP4 inhibitor | -- | Under clinical trials | Details |
| D206 | Lingguizhugan decoction | Traditional medicine | -- | -- | -- | Under clinical trials | Details |
| D207 | Liraglutide | Biological drug | DB06655 | GLP1R activator; GLP1R agonist; GCG receptor antagonist activity | Improve insulin resistance | Under clinical trials | Details |
| D208 | Lobeglitazone | Chemical drug | DB09198 | PPARG activator | Improve insulin resistance | Under clinical trials | Details |
| D209 | Losartan | Chemical drug | DB00678 | AGTR1 antagonist&binder | Anti-fibrosis | Under clinical trials | Details |
| D210 | Lovaza | Chemical drug | DB09539 | SREBF1 inhibitor | Hypolipidemic drug | Under clinical trials | Details |
| D211 | LPCN 1144 | Biological drug | -- | AR activator | Metabolic disorder drug | Under clinical trials | Details |
| D212 | Lubiprostone | Chemical drug | DB01046 | -- | -- | Under clinical trials | Details |
| D213 | Luseogliflozin | Chemical drug | DB12214 | -- | -- | Under clinical trials | Details |
| D214 | LYS006 | Chemical drug | -- | -- | -- | Under clinical trials | Details |
| D215 | Maple Syrup | Supplement | -- | -- | -- | Under clinical trials | Details |
| D216 | Maraviroc | Chemical drug | DB04835 | CCR5 antagonist; CCR5 binder | Anti-fibrosis | Under clinical trials | Details |
| D217 | Mastiha | Biological extract | -- | -- | -- | Under clinical trials | Details |
| D218 | Matricaria chamomilla L. | Biological extract | -- | -- | -- | Under clinical trials | Details |
| D219 | Maxicor | Chemical drug | -- | -- | -- | Under clinical trials | Details |
| D220 | MB12066 | Chemical drug | DB11948 | -- | -- | Under clinical trials | Details |
| D221 | MEDI0382 | Chemical drug | DB15194 | GLP1R inhibitor; GCGR inhibitor | Improve insulin resistance | Under clinical trials | Details |
| D222 | Melatonin | Chemical drug | DB01065 | MPO inhibitor; EPX inhibitor; CALR; ASMT | -- | Under clinical trials | Details |
| D223 | Metabolic Cofactor Supplementation | Supplement | -- | -- | -- | Under clinical trials | Details |
| D224 | Metadoxine | Chemical drug | DB16554 | -- | Antialcoholic drug | Under clinical trials | Details |
| D225 | Metformin | Chemical drug | DB00331 | PRKAB1 inducer activator; ETEDH inhibitor; GPD1 inhibitor | Improve insulin resistance | Under clinical trials | Details |
| D226 | Metreleptin | Biological drug | DB09046 | LEPR agonist | CNS drug | Under clinical trials | Details |
| D227 | Milled chia seeds | Herbal medicine | -- | -- | -- | Under clinical trials | Details |
| D228 | Misatol GL | Biological extract | -- | -- | -- | Failed in clinical trials | Details |
| D229 | MitoQ | Chemical drug | DB05063 | -- | Antiparkinsonian drug | Under clinical trials | Details |
| D230 | MK-4074 | Chemical drug | -- | ACC inhibitor | -- | Under clinical trials | Details |
| D231 | MN-001 | Chemical drug | DB12435 | -- | -- | Under clinical trials | Details |
| D232 | Moxonidine | Chemical drug | DB09242 | NISCH agonist | -- | Under clinical trials | Details |
| D233 | MSDC-0602K | Chemical drug | -- | MPC modulator | Antidiabetic drug | Failed in clinical trials | Details |
| D234 | Muliv strong syrup | Supplement | -- | -- | -- | Under clinical trials | Details |
| D235 | N-acetyl cysteine | Chemical drug | -- | SLC7A11 activator; GSS stimulator | Antiviral | Under clinical trials | Details |
| D236 | Nanocurcumin | Biological extract | -- | -- | Anticancer agent; NSAID | Under clinical trials | Details |
| D237 | Nesinaact | Chemical drug | -- | CD26 antigen inhibitor; PPARG agonist | Improve insulin resistance | Under clinical trials | Details |
| D238 | NGM395 | Miscellany | -- | GDNF receptor agonist | Hormones, hepatoprotectants | Under clinical trials | Details |
| D239 | Niacin | Supplement | DB00627 | NNMT binder | Hypolipidemic drug | Under clinical trials | Details |
| D240 | Nicotinamide | Chemical drug | DB02701 | PARP inhibitor | Metabolic disorder drug | Under clinical trials | Details |
| D241 | Nidufexor | Chemical drug | DB16255 | FXR modulator | Enhance lipid metabolism | Under clinical trials | Details |
| D242 | Nigella Sativa | Biological extract | -- | -- | Gastrointestinal drug | Under clinical trials | Details |
| D243 | Nitazoxanide | Chemical drug | DB00507 | POR inhibitor | Antiprotozoal drug | Under clinical trials | Details |
| D244 | Nivocasan | Chemical drug | DB12720 | -- | Protective drug | Under clinical trials | Details |
| D245 | Norursodeoxycholic acid | Chemical drug | DB16260 | -- | -- | Under clinical trials | Details |
| D246 | NRL972 | Chemical drug | -- | -- | Diagnostic contrast drug | Under clinical trials | Details |
| D247 | Nutraceutical mixture | Supplement | -- | -- | -- | Under clinical trials | Details |
| D248 | Obeticholic Acid | Chemical drug | DB05990 | NR1H4 activator; NR1H4 agonist; FXR agonist | Enhance lipid metabolism | Approval rejected | Details |
| D249 | Ocimum Basilicum | Herbal medicine | -- | -- | -- | Under clinical trials | Details |
| D250 | Odevixibat | Chemical drug | DB16261 | SLC10A2 inhibitor; ASBT inhibitor | -- | Under clinical trials | Details |
| D251 | OKT3 | Biological drug | DB00075 | CD3E antagonist | Immunosuppressant | Under clinical trials | Details |
| D252 | Oleanolic Acid | Chemical drug | -- | -- | -- | Under clinical trials | Details |