Repositioning Candidates
Repositioning candidates for NAFLD are derived from DrugBank which fall into three categories: therapeutic strategy-associated, target-associated, and indication-associated candidates. For each candidate, detailed properties are extracted from DrugBank, and related strategies, target and NAFLD-associated disease in NAFLDkb are presented with knowledge graphs.
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Tumor necrosis factor75 records.
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0003 | DB00005 | approved; investigational | biotech | Etanercept | Therapeutic strategy associated | Details |
| R0017 | DB00051 | approved; experimental | biotech | Adalimumab | Therapeutic strategy associated | Details |
| R0020 | DB00065 | approved | biotech | Infliximab | Therapeutic strategy associated | Details |
| R0043 | DB00132 | approved; investigational; nutraceutical | small molecule | alpha-Linolenic acid | Therapeutic strategy associated | Details |
| R0054 | DB00154 | investigational; nutraceutical | small molecule | Dihomo-gamma-linolenic acid | Therapeutic strategy associated | Details |
| R0163 | DB00480 | approved | small molecule | Lenalidomide | Therapeutic strategy associated | Details |
| R0214 | DB00608 | approved; investigational; vet_approved | small molecule | Chloroquine | Target associated | Details |
| R0233 | DB00668 | approved; vet_approved | small molecule | Epinephrine | Target associated | Details |
| R0254 | DB00724 | approved; investigational | small molecule | Imiquimod | Therapeutic strategy associated | Details |
| R0305 | DB00843 | approved | small molecule | Donepezil | Therapeutic strategy associated | Details |
| R0308 | DB00852 | approved | small molecule | Pseudoephedrine | Target associated | Details |
| R0382 | DB01041 | approved; investigational; withdrawn | small molecule | Thalidomide | Target associated | Details |
| R0514 | DB01407 | approved; investigational; vet_approved | small molecule | Clenbuterol | Target associated | Details |
| R0516 | DB01411 | investigational | small molecule | Pranlukast | Target associated | Details |
| R0522 | DB01427 | approved | small molecule | Amrinone | Target associated | Details |
| R0544 | DB01611 | approved | small molecule | Hydroxychloroquine | Therapeutic strategy associated | Details |
| R0581 | DB03316 | experimental | small molecule | 1,4-Dioxane | Target associated | Details |
| R0586 | DB03507 | experimental | small molecule | 6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One | Target associated | Details |
| R0599 | DB04335 | experimental; investigational | small molecule | Inosine | Therapeutic strategy associated | Details |
| R0661 | DB04956 | investigational | biotech | Afelimomab | Target associated | Details |
| R0677 | DB05017 | investigational | small molecule | YSIL6 | Target associated | Details |
| R0738 | DB05207 | investigational | small molecule | SD118 | Target associated | Details |
| R0740 | DB05218 | investigational | biotech | PN0621 | Target associated | Details |
| R0764 | DB05303 | investigational | small molecule | OMS-103HP | Target associated | Details |
| R0787 | DB05412 | investigational | small molecule | Talmapimod | Therapeutic strategy associated | Details |
| R0806 | DB05459 | investigational | biotech | Briakinumab | Indication associated | Details |
| R0809 | DB05470 | investigational | small molecule | VX-702 | Target associated | Details |
| R0822 | DB05507 | investigational | small molecule | VX-765 | Therapeutic strategy associated | Details |
| R0825 | DB05513 | investigational | small molecule | Atiprimod | Target associated | Details |
| R0859 | DB05744 | investigational | small molecule | CRx-139 | Therapeutic strategy associated | Details |
| R0864 | DB05758 | investigational | biotech | CYT007-TNFQb | Therapeutic strategy associated | Details |
| R0865 | DB05767 | investigational | small molecule | Andrographolide | Therapeutic strategy associated | Details |
| R0889 | DB05869 | investigational | small molecule | Ethyl pyruvate | Therapeutic strategy associated | Details |
| R0890 | DB05879 | investigational | biotech | AME-527 | Therapeutic strategy associated | Details |
| R0896 | DB05895 | investigational | biotech | HGS-TR2J | Therapeutic strategy associated | Details |
| R0904 | DB05959 | investigational | small molecule | ENMD-1198 | Therapeutic strategy associated | Details |
| R0906 | DB05968 | investigational | small molecule | PR-104 | Therapeutic strategy associated | Details |
| R0911 | DB05983 | investigational | small molecule | Bardoxolone methyl | Therapeutic strategy associated | Details |
| R0912 | DB05992 | investigational | small molecule | Plinabulin | Target associated | Details |
| R0981 | DB06324 | investigational | biotech | XmAb 2513 | Target associated | Details |
| R0992 | DB06360 | investigational | biotech | Lucatumumab | Target associated | Details |
| R1001 | DB06399 | investigational | biotech | Atacicept | Indication associated | Details |
| R1016 | DB06444 | investigational | small molecule | Dexanabinol | Target associated | Details |
| R1030 | DB06495 | investigational | biotech | Onercept | Therapeutic strategy associated | Details |
| R1035 | DB06511 | investigational | biotech | AMGN-0007 | Target associated | Details |
| R1053 | DB06599 | investigational | biotech | Lexatumumab | Therapeutic strategy associated | Details |
| R1069 | DB06643 | approved | biotech | Denosumab | Target associated | Details |
| R1076 | DB06674 | approved | biotech | Golimumab | Therapeutic strategy associated | Details |
| R1089 | DB06736 | approved; investigational | small molecule | Aceclofenac | Therapeutic strategy associated | Details |
| R1158 | DB08818 | approved; vet_approved | small molecule | Hyaluronic acid | Therapeutic strategy associated | Details |
| R1172 | DB08870 | approved; investigational | biotech | Brentuximab vedotin | Target associated | Details |
| R1175 | DB08879 | approved | biotech | Belimumab | Target associated | Details |
| R1183 | DB08904 | approved | biotech | Certolizumab pegol | Therapeutic strategy associated | Details |
| R1185 | DB08910 | approved | small molecule | Pomalidomide | Therapeutic strategy associated | Details |
| R1198 | DB09033 | approved | biotech | Vedolizumab | Therapeutic strategy associated | Details |
| R1251 | DB09221 | experimental | small molecule | Polaprezinc | Therapeutic strategy associated | Details |
| R1278 | DB09273 | experimental | small molecule | Doxofylline | Therapeutic strategy associated | Details |
| R1322 | DB10770 | approved | biotech | Foreskin fibroblast (neonatal) | Target associated | Details |
| R1324 | DB10772 | approved | biotech | Foreskin keratinocyte (neonatal) | Target associated | Details |
| R1329 | DB11079 | approved | small molecule | Trolamine salicylate | Therapeutic strategy associated | Details |
| R1360 | DB11265 | nutraceutical | biotech | Curcuma xanthorrhiza oil | Therapeutic strategy associated | Details |
| R1378 | DB11582 | experimental | small molecule | Thiocolchicoside | Target associated | Details |
| R1385 | DB11626 | approved | biotech | Tasonermin | Therapeutic strategy associated | Details |
| R1399 | DB11752 | investigational | small molecule | Bryostatin 1 | Target associated | Details |
| R1423 | DB11967 | approved; investigational | small molecule | Binimetinib | Therapeutic strategy associated | Details |
| R1431 | DB12077 | investigational | biotech | Urelumab | Target associated | Details |
| R1433 | DB12140 | investigational | small molecule | Dilmapimod | Therapeutic strategy associated | Details |
| R1440 | DB12249 | approved; investigational | biotech | Stem bromelain | Therapeutic strategy associated | Details |
| R1455 | DB12589 | investigational | biotech | Dacetuzumab | Target associated | Details |
| R1465 | DB12831 | investigational | small molecule | Gabexate | Therapeutic strategy associated | Details |
| R1494 | DB13751 | approved; experimental | small molecule | Glycyrrhizic acid | Therapeutic strategy associated | Details |
| R1518 | DB14487 | approved; investigational | small molecule | Zinc acetate | Therapeutic strategy associated | Details |
| R1545 | DB14845 | approved; investigational | small molecule | Filgotinib | Therapeutic strategy associated | Details |
| R1570 | DB15719 | approved | biotech | Belantamab mafodotin | Therapeutic strategy associated | Details |
| R1605 | DB16665 | approved | biotech | Idecabtagene vicleucel | Target associated | Details |