Investigational Drugs
Investigational drugs for NAFLD are derived from global clinical trials with the latest progress, and detailed drug properties are extracted from DrugBank and PubChem. For each drug, related therapeutic strategies, targets, and clinical trials in NAFLDkb are presented with knowledge graphs.
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581 records.
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D303 | Rifampicin | Chemical drug | DB01045 | NR1I2 agonist | Antimycobacterial drug | Under clinical trials | Details |
| D304 | Rifaximin | Chemical drug | DB01220 | NR1I2 agonist | Antibiotic drug | Under clinical trials | Details |
| D305 | Rimonabant | Chemical drug | DB06155 | CNR1 antagonist | Antialcoholic drug; CNS drug | Under clinical trials | Details |
| D306 | RO5093151 | Biological drug | -- | -- | -- | Under clinical trials | Details |
| D307 | Roflumilast | Chemical drug | DB01656 | PDE4C inhibitor; PDE4B inhibitor; Pde4 inhibitor; PDE4A inhibitor; PDE4D inhibitor | Antiasthmatic drug | Under clinical trials | Details |
| D308 | Rosa canina | Biological extract | -- | -- | -- | Under clinical trials | Details |
| D309 | Rosa damascena | Biological extract | -- | -- | -- | Under clinical trials | Details |
| D310 | Rosemary | Biological drug | DB14272 | -- | -- | Under clinical trials | Details |
| D311 | Rosiglitazone | Chemical drug | DB00412 | PPARG agonist; PPARA; PPARD | Improve insulin resistance | Failed in clinical trials | Details |
| D312 | Rosuvastatin | Chemical drug | DB01098 | HMGCR inhibitor | Enhance lipid metabolism | Under clinical trials | Details |
| D313 | Runihol | Miscellany | -- | -- | -- | Under clinical trials | Details |
| D314 | RYI-018 | Biological drug | DB15115 | -- | -- | Under clinical trials | Details |
| D315 | Saberry capsules | Herbal medicine | -- | -- | -- | Under clinical trials | Details |
| D316 | S-adenosyl-L-methionine | Chemical drug | DB00118 | GNMT cofactor | Antiviral | Under clinical trials | Details |
| D317 | Saffron | Herbal medicine | -- | -- | -- | Under clinical trials | Details |
| D318 | Salsalate | Chemical drug | DB01399 | PTGS2 inhibitor; PTGS1 inhibitor | NSAID | Under clinical trials | Details |
| D319 | Sancailianmei Particle | Traditional medicine | -- | -- | -- | Under clinical trials | Details |
| D320 | SAR425899 | Chemical drug | -- | -- | -- | Under clinical trials | Details |
| D321 | Saroglitazar | Chemical drug | DB13115 | PPARA agonist; PPARG agonist | Antidiabetic drug | Approved in India | Details |
| D322 | Sebelipase Alfa | Biological drug | DB11563 | -- | Enzyme replacement therapy | Under clinical trials | Details |
| D323 | Secukinumab | Biological drug | DB09029 | IL17A antagonist; antibody | Immunomodulator | Under clinical trials | Details |
| D324 | Seladelpar | Chemical drug | DB12390 | -- | -- | Failed in clinical trials | Details |
| D325 | Selimarine | Miscellany | -- | -- | -- | Under clinical trials | Details |
| D326 | Selonsertib | Chemical drug | DB14916 | MAP3K5 inhibitor; ASK1 inhibitor | Anti-oxidative stress; Anticancer agent | Failed in clinical trials | Details |
| D327 | Semaglutide | Chemical drug | DB13928 | GLP1R agonist | Antidiabetic drug | Under clinical trials | Details |
| D328 | Serine | Chemical drug | DB00133 | SRR | Improve insulin resistance | Under clinical trials | Details |
| D329 | SGM-1019 | Chemical drug | -- | -- | -- | Failed in clinical trials | Details |
| D330 | Shan Zha Xiao Zhi capsule | Traditional medicine | -- | -- | -- | Under clinical trials | Details |
| D331 | Shizazi thyme | Herbal medicine | -- | -- | -- | Under clinical trials | Details |
| D332 | Volixibat | Chemical drug | DB13914 | SLC10A2 inhibitor; ASBT inhibitor | Lipid regulating agents | Failed in clinical trials | Details |
| D333 | Sibutramine | Chemical drug | DB01105 | -- | -- | Under clinical trials | Details |
| D334 | Siliphos-Selenium-Methionine-Alpha Lipoic Acid | Miscellany | -- | -- | Antiviral | Under clinical trials | Details |
| D335 | Silybum marianum | Herbal medicine | -- | -- | -- | Under clinical trials | Details |
| D336 | Silymarin | Biological drug | DB14375 | -- | Antiviral; Antioxidant; Antifibrotic; Anti-inflammatory | Under clinical trials | Details |
| D337 | Simtuzumab | Biological drug | DB12152 | LOXL2; antibody | Anti-fibrosis; Anticancer agent; Immunomodulator; | Failed in clinical trials | Details |
| D338 | Sitagliptin | Chemical drug | DB01261 | DPP4 inhibitor | Antidiabetic drug | Under clinical trials | Details |
| D339 | Smectite | Miscellany | -- | -- | -- | Under clinical trials | Details |
| D340 | SNP-610 | Biological drug | -- | -- | -- | Under clinical trials | Details |
| D341 | SNP-612 | Miscellany | -- | -- | -- | Under clinical trials | Details |
| D342 | Solithromycin | Chemical drug | DB09308 | NF-kB inhibitor | Antibiotic drug, anti-inflammatory | Under clinical trials | Details |
| D343 | Somatropin | Biological drug | DB00052 | GHR ligand; PRLR ligand | Hormone replacement drug | Under clinical trials | Details |
| D344 | Spironolactone | Chemical drug | DB00421 | AR antagonist; PGR agonist; NR1I2 | Diuretic drug | Under clinical trials | Details |
| D345 | Spirulina | Biological drug | DB14744 | -- | Prebiotics | Under clinical trials | Details |
| D346 | SponserR | Miscellany | -- | -- | -- | Under clinical trials | Details |
| D347 | SPP-1 | Chemical drug | -- | -- | -- | Under clinical trials | Details |
| D348 | Stanol | Biological extract | -- | -- | -- | Under clinical trials | Details |
| D349 | Statins | Miscellany | -- | -- | -- | Under clinical trials | Details |
| D350 | Stevia | Chemical drug | DB15136 | -- | -- | Under clinical trials | Details |
| D351 | Stronger Neo-Minophagen C | Traditional medicine | -- | -- | -- | Under clinical trials | Details |
| D352 | Sublimated mares milk | Supplement | -- | -- | -- | Under clinical trials | Details |