CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of NAFLD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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FXR10 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C01425 | BRD-A59808129 | guggulsterone | NR3C1; AR; NR3C2; PGR; NR1H4 | IKK inhibitor; FXR antagonist; Cholesterol inhibitor; Estrogen receptor agonist; Pregnane X receptor agonist; Progesterone receptor agonist | -- | Details |
| C02106 | BRD-A86109770 | guggulsterone | NR3C1; AR; NR3C2; PGR; NR1H4 | IKK inhibitor; FXR antagonist; Cholesterol inhibitor; Estrogen receptor agonist; Pregnane X receptor agonist; Progesterone receptor agonist | -- | Details |
| C10208 | BRD-K24656285 | farnesol | MAOB | FXR agonist; PPAR receptor agonist; NFkB pathway activator; Monoamine oxidase B inhibitor | -- | Details |
| C10835 | BRD-K26674531 | GR-235 | NR1H4 | FXR antagonist; Estrogen receptor agonist; Progesterone receptor agonist | -- | Details |
| C13238 | BRD-K34170797 | fexaramine | NR1H4 | FXR agonist | -- | Details |
| C19808 | BRD-K54640016 | WAY-362450 | NR1H4 | FXR agonist | -- | Details |
| C20602 | BRD-K57139258 | z-guggulsterone | NR1H4 | FXR antagonist; Progesterone receptor agonist | -- | Details |
| C22843 | BRD-K64245000 | GW-4064 | NR1H4 | FXR agonist | -- | Details |
| C23749 | BRD-K67097529 | SR-12813 | NR1I2 | FXR agonist | -- | Details |
| C30388 | BRD-K88186167 | GW-4064 | NR1H4 | FXR agonist | -- | Details |