Therapeutic Targets

Therapeutic targets for NAFLD are manually extracted from research articles. For each target, reference researches are provided, and target details are derived from UniProt. Related drugs and repositioning candidates in NAFLDkb are presented with knowledge graphs.

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45 records.
Target ID Target Name GENE Action Class UniProtKB ID Entry Name
T21 Diacylglycerol O-acyltransferase 2 DGAT2 inhibitor Enzyme Q96PD7 DGAT2_HUMAN Details
T22 Stearoyl-CoA desaturase SCD inhibitor Enzyme O00767 SCD_HUMAN Details
T23 Type-1 angiotensin II receptor AGTR1 antagonist GPCR P30556 AGTR1_HUMAN Details
T24 C-C chemokine receptor type 2 CCR2 antagonist GPCR P41597 CCR2_HUMAN Details
T25 C-C chemokine receptor type 5 CCR5 antagonist GPCR P51681 CCR5_HUMAN Details
T26 Thyroid hormone receptor beta THRB agonist Nuclear hormone receptor P10828 THB_HUMAN Details
T28 Fibroblast growth factor 21 FGF21 analogue Secreted Q9NSA1 FGF21_HUMAN Details
T29 Fibroblast growth factor 19 FGF19 variant Secreted O95750 FGF19_HUMAN Details
T30 Lysyl oxidase homolog 2 LOXL2 antibody Enzyme Q9Y4K0 LOXL2_HUMAN Details
T31 Galectin-3 LGALS3 inhibitor Enzyme P17931 LEG3_HUMAN Details
T32 Ketohexokinase KHK inhibitor Enzyme P50053 KHK_HUMAN Details
T33 Mitochondrial pyruvate carrier 1 MPC1 inhibitor Enzyme Q9Y5U8 MPC1_HUMAN Details
T34 Mitochondrial pyruvate carrier 2 MPC2 inhibitor Enzyme O95563 MPC2_HUMAN Details
T35 Platelet glycoprotein Ib alpha GP1BA inhibitor Enzyme P07359 GP1BA_HUMAN Details
T36 Caspase-6 CASP6 inhibitor Enzyme P55212 CASP6_HUMAN Details
T37 Caspase-2 CASP2 inhibitor Enzyme P42575 CASP2_HUMAN Details
T38 Caspase-4 Casp4 inhibitor Enzyme P49662 CASP4_HUMAN Details
T39 Glutathione S-transferase Mu 2 GSTM2 agonist Enzyme P28161 GSTM2_HUMAN Details
T40 N-formyl peptide receptor 2 FPR2 inhibitor Enzyme P25090 FPR2_HUMAN Details
T41 X-box-binding protein 1 XBP1 inhibitor Protein P17861 XBP1_HUMAN Details