Investigational Drugs
Investigational drugs for NAFLD are derived from global clinical trials with the latest progress, and detailed drug properties are extracted from DrugBank and PubChem. For each drug, related therapeutic strategies, targets, and clinical trials in NAFLDkb are presented with knowledge graphs.
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581 records.
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D253 | Oleoylethanolamide | Chemical drug | DB16495 | -- | -- | Under clinical trials | Details |
| D254 | Oligofructose | Supplement | -- | -- | -- | Under clinical trials | Details |
| D255 | Olive oil | Biological drug | DB09567 | -- | -- | Under clinical trials | Details |
| D256 | Oltipraz | Chemical drug | DB12539 | -- | Anticancer agent; antiviral | Under clinical trials | Details |
| D257 | OMACOR | Chemical drug | DB09539 | -- | Hypolipidemic drug | Under clinical trials | Details |
| D258 | Omega 3 PUFA | Chemical drug | DB11133 | PPARG ligand; PPARA activator | Hypolipidemic drug | Under clinical trials | Details |
| D259 | Omeprazole | Chemical drug | DB00338 | AHR agonist | -- | Under clinical trials | Details |
| D260 | Orlistat | Chemical drug | DB01083 | FASN inhibitor | Enhance lipid metabolism | Under clinical trials | Details |
| D261 | P2pal-18S | Chemical drug | -- | -- | -- | Under investigation | Details |
| D262 | Palatinose | Chemical drug | -- | -- | -- | Under clinical trials | Details |
| D263 | Pancrelipase | Biological drug | DB00085 | -- | -- | Under clinical trials | Details |
| D264 | Pantoprazole | Chemical drug | DB00213 | gastric H-K-ATPase inhibitor; ATP4B inhibitor; ATP4A inhibitor | Gastrointestinal drug | Under clinical trials | Details |
| D265 | Pemafibrate | Chemical drug | DB15212 | PPARA modulator | Anti-inflammatory | Under clinical trials | Details |
| D266 | Pentoxifylline | Chemical drug | DB00806 | ADORA2A antagonist; ADORA1 antagonist; PDE4A inhibitor; PDE3B inhibitor; PDE4B inhibitor; PDE5A inhibitor; PDE8A inhibitor; PDE4C inhibitor; PDE11A inhibitor; PDE7A inhibitor; PDE7B inhibitor; PDE4D inhibitor; PDE3A inhibitor | Anti-inflammatory; Cardiovascular drug | Under clinical trials | Details |
| D267 | Perindopril | Chemical drug | DB00790 | ACE inhibitor | Antihypertensive drug | Under clinical trials | Details |
| D268 | PF-05221304 | Chemical drug | -- | ACC inhibitor | Enhance lipid metabolism | Under clinical trials | Details |
| D269 | PF-06835919 | Chemical drug | -- | Ketohexokinase inhibitor | Enhance lipid metabolism | Under clinical trials | Details |
| D270 | PF-06865571 | Chemical drug | -- | DGAT2 inhibitor | Enhance lipid metabolism | Under clinical trials | Details |
| D271 | Phentermine | Chemical drug | DB00191 | MAOB antagonist; MAOA antagonist; SLC6A2 inhibitor; SLC6A3 inhibitor; SLC6A4 inhibitor; SLC6A2 stimulator; SLC6A3 stimulator | Anorexic; CNS stimulant | Under clinical trials | Details |
| D272 | Phlebotomy | Miscellany | -- | -- | -- | Under clinical trials | Details |
| D273 | Phosphatidylcholine | Chemical drug | DB15834 | -- | -- | Under clinical trials | Details |
| D274 | Phytosterol | Supplement | -- | -- | Hypolipidemic drug | Under clinical trials | Details |
| D275 | Pioglitazone | Chemical drug | DB01132 | PPARG agonist | Improve insulin resistance | Advanced in clinical trials | Details |
| D276 | Piperine | Chemical drug | DB12582 | NR1I2 | -- | Under clinical trials | Details |
| D277 | Pitavastatin | Chemical drug | DB08860 | HMGCR inhibitor | Enhance lipid metabolism | Failed in clinical trials | Details |
| D278 | Plantago major seed | Herbal medicine | -- | -- | -- | Under clinical trials | Details |
| D279 | Plantago Psyllium | Biological drug | DB11097 | -- | -- | Under investigation | Details |
| D280 | Pomegranate extract | Biological drug | DB14317 | -- | -- | Under clinical trials | Details |
| D281 | Prebiotic | Supplement | -- | -- | -- | Under clinical trials | Details |
| D282 | PRIM-DJ2727 | Supplement | -- | -- | -- | Under clinical trials | Details |
| D283 | Proanthocyanidin | Chemical drug | DB04941 | CFTR antagonist | -- | Under clinical trials | Details |
| D284 | Probiotic | Supplement | -- | -- | -- | Under clinical trials | Details |
| D285 | Proglumide | Chemical drug | DB13431 | -- | Antiulcerative drug | Under clinical trials | Details |
| D286 | Propolis | Biological extract | -- | -- | -- | Under clinical trials | Details |
| D287 | Protandim | Supplement | -- | -- | -- | Under clinical trials | Details |
| D288 | ProWHEY 94 CFM | Miscellany | -- | -- | -- | Under clinical trials | Details |
| D289 | Purslane | Biological drug | DB14327 | -- | -- | Under clinical trials | Details |
| D290 | Px-104 | Chemical drug | DB15416 | -- | -- | Under clinical trials | Details |
| D291 | PXL065 | Chemical drug | -- | AMPK activator | Improve insulin resistance | Under clinical trials | Details |
| D292 | PXL770 | Chemical drug | -- | AMPK activator | Improve insulin resistance | Under clinical trials | Details |
| D293 | Quercetin | Supplement | DB04216 | AHR; EIF3F; SF3B3; NR1I2 activator | -- | Under clinical trials | Details |
| D294 | Quinidine | Chemical drug | DB00908 | KCNH2 inhibitor | Antiadrenergic drug; Antiarrhythmic; Antiprotozoal drug; Cholinergic drug | Under clinical trials | Details |
| D295 | Qushi Huayu Decoction | Traditional medicine | -- | AMPK activator | Improve insulin resistance | Under clinical trials | Details |
| D296 | Rabeprazol sodium | Miscellany | -- | -- | -- | Under clinical trials | Details |
| D297 | Raltegravir | Chemical drug | DB06817 | -- | Anti-HIV drug | Under clinical trials | Details |
| D298 | Ranolazine | Chemical drug | DB00243 | -- | -- | Under clinical trials | Details |
| D299 | Remogliflozin | Chemical drug | -- | -- | -- | Under clinical trials | Details |
| D300 | Resmetirom | Chemical drug | DB12914 | THRB agonist | Anti-fibrosis | Advanced in clinical trials | Details |
| D301 | Resveratrol | Chemical drug | DB02709 | ALOX15; ALOX5; AHR; NR1I2; NR1I3 | Anticancer agent | Under clinical trials | Details |
| D302 | RGMA001 | Miscellany | -- | -- | -- | Under clinical trials | Details |