CMap Candidates
CMap (Connectivity Map) candidates are extracted from CLUE (CMap and LINCS Unified Environment), with detailed information, e.g., perturbagen time and dose, compound structure, targets, SMILES, mechanism of action. Two publicly available gene expression profiles of NAFLD are used to calculate individual connectivity scores and corresponding statistical significances for these candidates.
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PPAR44 records.
| CMap ID | Pert ID | Compound Name | Targets | MoA | Compound Aliases | |
|---|---|---|---|---|---|---|
| C00006 | BRD-A00147595 | balaglitazone | PPARG | Insulin sensitizer; PPAR receptor partial agonist | -- | Details |
| C00300 | BRD-A11776908 | enilconazole | CYP1A2; CYP2B6; CYP2C9; CYP2J2; CYP3A4; CYP3A5; CYP19A1; PPARA; PTGER2; NR1I2 | Sterol demethylase inhibitor | -- | Details |
| C00330 | BRD-A13084692 | troglitazone | PPARG | Insulin sensitizer; PPAR receptor agonist | -- | Details |
| C00395 | BRD-A15415227 | GW-1929 | PPARG | Insulin sensitizer; PPAR receptor agonist | -- | Details |
| C00417 | BRD-A16694057 | BADGE | PPARG | PPAR receptor antagonist | badge | Details |
| C00624 | BRD-A24560335 | efatutazone | PPARG | PPAR receptor agonist | -- | Details |
| C01172 | BRD-A48430263 | pioglitazone | PPARG | Insulin sensitizer; PPAR receptor agonist | -- | Details |
| C01186 | BRD-A49358627 | ciprofibrate | PPARA | PPAR receptor agonist | -- | Details |
| C01760 | BRD-A72066420 | mifobate | PPARG | PPAR receptor antagonist | -- | Details |
| C01778 | BRD-A72596465 | GW-6471 | PPARA | PPAR receptor antagonist | -- | Details |
| C02238 | BRD-A93000692 | ciglitazone | PPARG | PPAR receptor agonist | -- | Details |
| C02345 | BRD-A97437073 | rosiglitazone | PPARG | Insulin sensitizer; PPAR receptor agonist | -- | Details |
| C03008 | BRD-K01902415 | pirinixic-acid | PPARA | PPAR receptor agonist | -- | Details |
| C04307 | BRD-K06080977 | eicosatetraynoic-acid | ALOX12; PPARA; PPARG; PTGS1 | Cyclooxygenase inhibitor; Lipoxygenase inhibitor | -- | Details |
| C05502 | BRD-K09900591 | caffeic-acid | ALOX5 | Lipoxygenase inhibitor; NFKB pathway inhibitor; HIV integrase inhibitor; PPAR receptor modulator; TNF production inhibitor; Nitric oxide production inhibitor; Tumor necrosis factor production inhibitor | -- | Details |
| C05864 | BRD-K11129031 | gemfibrozil | CYP2C8; LPL; PPARA | Lipoprotein lipase activator | -- | Details |
| C06989 | BRD-K14609189 | BRD-K14609189 | PPARG | PPAR receptor agonist | -- | Details |
| C07083 | BRD-K14880289 | GW-501516 | PPARD | Insulin sensitizer; PPAR receptor agonist | -- | Details |
| C07273 | BRD-K15507868 | tesaglitazar | PPARA; PPARG | Insulin sensitizer; PPAR receptor agonist | -- | Details |
| C08440 | BRD-K19111024 | clofibric-acid | PPARA | PPAR receptor agonist | -- | Details |
| C10208 | BRD-K24656285 | farnesol | MAOB | FXR agonist; PPAR receptor agonist; NFkB pathway activator; Monoamine oxidase B inhibitor | -- | Details |
| C11091 | BRD-K27499107 | carbacyclin | PPARD; PTGIR | IP receptor activator; PPAR receptor agonist | -- | Details |
| C11533 | BRD-K28849549 | mesalazine | ALOX5; PPARG; PTGS1; PTGS2 | Lipoxygenase inhibitor; Cyclooxygenase inhibitor; Prostanoid receptor antagonist | -- | Details |
| C12516 | BRD-K31843556 | T-0070907 | PPARG | PPAR receptor antagonist | -- | Details |
| C15357 | BRD-K40656405 | L-165041 | PPARD | PPAR receptor agonist | -- | Details |
| C15607 | BRD-K41494493 | bisphenol-a | PPARG | Estrogen receptor agonist | -- | Details |
| C16820 | BRD-K45252063 | clofibrate | PPARA | PPAR receptor agonist | -- | Details |
| C17094 | BRD-K46018455 | bezafibrate | PPARA; PPARD; PPARG | PPAR receptor agonist | -- | Details |
| C18303 | BRD-K49840922 | etofylline-clofibrate | PPARA | Platelet aggregation inhibitor; Lipase clearing factor inhibitor | -- | Details |
| C18489 | BRD-K50388907 | fenofibrate | PPARA | PPAR receptor agonist | -- | Details |
| C19318 | BRD-K53097745 | pterostilbene | PTGS2 | PPAR receptor agonist; Cyclooxygenase inhibitor | -- | Details |
| C19829 | BRD-K54708045 | nTZDpa | PPARG | PPAR receptor agonist | ntzdpa | Details |
| C20632 | BRD-K57222227 | indometacin | PTGDR2; PPARG; PTGS1; PTGS2 | Cyclooxygenase inhibitor | -- | Details |
| C23700 | BRD-K66956375 | oleoylethanolamide | GPR119; PPARA | PPAR receptor agonist; Potassium channel blocker; Cannabinoid receptor agonist; Glucose dependent insulinotropic receptor agonist | -- | Details |
| C25947 | BRD-K73999723 | telmisartan | AGTR1; PPARG | Angiotensin receptor antagonist | -- | Details |
| C27038 | BRD-K77345217 | gallic-acid | CA1 | PPAR receptor agonist; Beta amyloid inhibitor | -- | Details |
| C28772 | BRD-K82983861 | GW-0742 | PPARD | Insulin sensitizer; PPAR receptor agonist | -- | Details |
| C29298 | BRD-K84709232 | caffeic-acid | ALOX5 | Lipoxygenase inhibitor; NFKB pathway inhibitor; HIV integrase inhibitor; PPAR receptor modulator; TNF production inhibitor; Nitric oxide production inhibitor; Tumor necrosis factor production inhibitor | -- | Details |
| C29823 | BRD-K86465814 | HO-013 | PPARG | PPAR receptor agonist | -- | Details |
| C31844 | BRD-K92870997 | pterostilbene | PTGS2 | PPAR receptor agonist; Cyclooxygenase inhibitor | -- | Details |
| C31981 | BRD-K93258693 | GW-9662 | PPARG | PPAR receptor antagonist | -- | Details |
| C32931 | BRD-K96263742 | GW-7647 | PPARA | PPAR receptor agonist | -- | Details |
| C33572 | BRD-K98372770 | L-2167 | PPARD | PPAR receptor agonist | -- | Details |
| C33661 | BRD-K98684188 | GSK-0660 | PPARD | PPAR receptor antagonist | -- | Details |